6-Chloronicotine

Last updated
6-Chloronicotine
(S)-6-Chloronicotine.svg
Identifiers
  • 2-chloro-5-[(2S)-1-methylpyrrolidin-2-yl]pyridine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C10H13ClN2
Molar mass 196.68 g·mol−1
3D model (JSmol)
  • CN1CCC[C@H]1C2=CN=C(C=C2)Cl
  • InChI=1S/C10H13ClN2/c1-13-6-2-3-9(13)8-4-5-10(11)12-7-8/h4-5,7,9H,2-3,6H2,1H3/t9-/m0/s1
  • Key:SVVOLGNZRGLPIU-VIFPVBQESA-N

6-Chloronicotine is a drug which acts as an agonist at neural nicotinic acetylcholine receptors. It substitutes for nicotine in animal studies with around twice the potency, and shows antinociceptive effects. [1] [2] [3] [4]

See also

References

  1. ↑ Dukat M, Fiedler W, Dumas D, Damaj I, Martin BR, Rosecrans JA, James JR, Glennon RA (1996). "Pyrrolidine-modified and 6-substituted analogs of nicotine: A structure—affinity investigation". European Journal of Medicinal Chemistry. 31 (11): 875–888. doi:10.1016/S0223-5234(97)89850-9.
  2. ↑ Damaj MI, Fei-Yin M, Dukat M, Glassco W, Glennon RA, Martin BR (March 1998). "Antinociceptive responses to nicotinic acetylcholine receptor ligands after systemic and intrathecal administration in mice". The Journal of Pharmacology and Experimental Therapeutics. 284 (3): 1058–65. doi:10.1016/S0022-3565(24)37303-3. PMID   9495867.
  3. ↑ Dukat M, Dowd M, Damaj MI, Martin B, El-Zahabi MA, Glennon RA (1999). "Synthesis, receptor binding and QSAR studies on 6-substituted nicotine derivatives as cholinergic ligands". European Journal of Medicinal Chemistry. 34 (1): 31–40. doi:10.1016/S0223-5234(99)80038-5.
  4. ↑ Latli B, D'Amour K, Casida JE (June 1999). "Novel and potent 6-chloro-3-pyridinyl ligands for the alpha4beta2 neuronal nicotinic acetylcholine receptor". Journal of Medicinal Chemistry. 42 (12): 2227–34. doi:10.1021/jm980721x. PMID   10377228.
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