Toloxatone

Toloxatone
Clinical data
Routes of; administration	Oral
ATC code	N06AG03 ( WHO );
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 5-(hydroxymethyl)-3-m-tolyloxazolidin-2-one;
CAS Number	29218-27-7 ;
PubChem CID	34521 ;
ChemSpider	31769 ;
UNII	5T206015T5 ;
KEGG	D02559 ;
ChEBI	CHEBI:134870 ;
ChEMBL	ChEMBL18116 ;
CompTox Dashboard (EPA)	DTXSID40865478 ;
ECHA InfoCard	100.045.006
Chemical and physical data
Formula	C11H13NO3
Molar mass	207.229 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES O=C2OC(CO)CN2c1cccc(c1)C;
	InChI InChI=1S/C11H13NO3/c1-8-3-2-4-9(5-8)12-6-10(7-13)15-11(12)14/h2-5,10,13H,6-7H2,1H3 ; Key:MXUNKHLAEDCYJL-UHFFFAOYSA-N ;

Last updated January 30, 2026

Toloxatone (Humoryl) is an antidepressant launched in 1984 in France by Sanofi Aventis for the treatment of depression. It was discontinued in 2002.^[1] It acts as a selective reversible inhibitor of MAO-A (RIMA).^[2]

Synthesis

The reaction between glycidol (1) and m-toluidine (2) gives 3-m-toluidinopropane-1,2-diol (3). Treatment with diethyl carbonate (4) in the presence of sodium methoxide leads to an intermolecular cycloaddition to give tomoxatone.^[3]^[4]^[5]

References

↑ "Humoryl 200mg gelule 30". Archived from the original on 2021-06-08. Retrieved 2021-06-08.
↑ Berlin I, Zimmer R, Thiede HM, et al. (December 1990). "Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase-A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects". British Journal of Clinical Pharmacology. 30 (6): 805–16. doi:10.1111/j.1365-2125.1990.tb05445.x. PMC 1368300 . PMID 1705137.
↑ Sungurbey, K .; Castaer, J .; Toloxatone. Drugs Fut 1976, 1, 12, 569.
↑ Douzon, C.; Fauvan, C.; Une nouvelle serie d'antidpresseurs: les derivs de l'hydroxymthyl-5-oxazolidinone-2. Chimie Thrapeutique 1973, 3, 324-327.
↑ DE2012120 Claude P Fauran, Guy M Raynaud, Rene A Oliver, Colette A Douzon, U.S. patent 3,655,687 (1972 to Delalande Sa).

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[1] "Humoryl 200mg gelule 30". Archived from the original on 2021-06-08. Retrieved 2021-06-08.

[pmid1705137-2] Berlin I, Zimmer R, Thiede HM, et al. (December 1990). "Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase-A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects". British Journal of Clinical Pharmacology. 30 (6): 805–16. doi:10.1111/j.1365-2125.1990.tb05445.x. PMC 1368300 . PMID 1705137.

[3] Sungurbey, K .; Castaer, J .; Toloxatone. Drugs Fut 1976, 1, 12, 569.

[4] Douzon, C.; Fauvan, C.; Une nouvelle serie d'antidpresseurs: les derivs de l'hydroxymthyl-5-oxazolidinone-2. Chimie Thrapeutique 1973, 3, 324-327.

[5] DE2012120 Claude P Fauran, Guy M Raynaud, Rene A Oliver, Colette A Douzon, U.S. patent 3,655,687 (1972 to Delalande Sa).

[1]

[2]

[3]

[4]

[5]

v t e Anxiolytics (N05B)
5-HT_1AR Tooltip 5-HT1A receptor agonists	Buspirone Gepirone Tandospirone
GABA_AR Tooltip GABAA receptor PAMs Tooltip positive allosteric modulators	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam ^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam ^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem ^‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Carisoprodol Chlormezanone ^‡ Ethanol (alcohol) Etifoxine
Gabapentinoids (α₂δVDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIs Tooltip Selective serotonin reuptake inhibitors (e.g., escitalopram) SNRIs Tooltip Serotonin-norepinephrine reuptake inhibitors (e.g., duloxetine) SARIs Tooltip Serotonin antagonist and reuptake inhibitors (e.g., trazodone) TCAs Tooltip Tricyclic antidepressants (e.g., clomipramine ^#) TeCAs Tooltip Tetracyclic antidepressants (e.g., mirtazapine) MAOIs Tooltip Monoamine oxidase inhibitors (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol, atenolol, betaxolol, nadolol, oxprenolol, pindolol)
Others	Benzoctamine Cycloserine Fabomotizole Hydroxyzine Lorpiprazole Mebicar Mepiprazole Nicotine (tobacco) Opipramol Oxaflozane ^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^# WHO-EM ^‡ Withdrawn from market Clinical trials: ^† Phase III ^§Never to phase III

Toloxatone

Contents

Synthesis

See also

References

Clinical data

Routes of administration	Oral
ATC code	N06AG03 ( WHO )
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 5-(hydroxymethyl)-3-m-tolyloxazolidin-2-one
CAS Number	29218-27-7 ^Y
PubChem CID	34521
ChemSpider	31769 ^Y
UNII	5T206015T5
KEGG	D02559 ^Y
ChEBI	CHEBI:134870
ChEMBL	ChEMBL18116 ^Y
CompTox Dashboard (EPA)	DTXSID40865478
ECHA InfoCard	100.045.006
Chemical and physical data
Formula	C₁₁H₁₃NO₃
Molar mass	207.229 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C2OC(CO)CN2c1cccc(c1)C
InChI InChI=1S/C11H13NO3/c1-8-3-2-4-9(5-8)12-6-10(7-13)15-11(12)14/h2-5,10,13H,6-7H2,1H3^Y Key:MXUNKHLAEDCYJL-UHFFFAOYSA-N^Y