SKF-91488

SKF-91488

Names
Preferred IUPAC name 4-(Dimethylamino)butyl carbamimidothioate
Identifiers
CAS Number	68643-23-2
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL1230270
ChemSpider	5037
DrugBank	DB07106
PubChem CID	5227
UNII	1I4LVX494H
CompTox Dashboard (EPA)	DTXSID50988329
InChI InChI=1S/C7H17N3S/c1-10(2)5-3-4-6-11-7(8)9/h3-6H2,1-2H3,(H3,8,9) Key: UFYJLJINUGVUHO-UHFFFAOYSA-N
SMILES [H]/N=C(/N)\SCCCCN(C)C
Properties
Chemical formula	C7H17N3S
Molar mass	175.29 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

SKF-91488 is a histamine N-methyltransferase inhibitor. It prevents the degradation of histamine, leading to increased histamine levels. ^{[1] [2]}

See also

• α-Fluoromethylhistidine
• Histidine methyl ester

References

1. Thakkar, Mahesh M. (February 2011). "Histamine in the regulation of wakefulness". Sleep Medicine Reviews. 15 (1): 65–74. doi:10.1016/j.smrv.2010.06.004. PMC   3016451 . PMID   20851648.
2. Tamaoki, J.; Chiyotani, A.; Tagaya, E.; Isono, K.; Konno, K. (1994). "Histamine N-methyltransferase Modulates Human Bronchial Smooth Muscle Contraction". Mediators of Inflammation. 3 (2): 125–129. doi: 10.1155/S0962935194000153 . PMC   2367027 . PMID   18472930.