Iproclozide

Iproclozide
Clinical data
Routes of; administration	Oral
ATC code	N06AF06 ( WHO );
Legal status
Legal status	BR: Class C1 (Other controlled substances); In general: uncontrolled;
Identifiers
	IUPAC name 2-(4-chlorophenoxy)-N-isopropyl-acetohydrazide;
CAS Number	3544-35-2 ;
PubChem CID	19063 ;
ChemSpider	17998 ;
UNII	1II9D6CB3J ;
KEGG	D07338 ;
ChEMBL	ChEMBL91238 ;
CompTox Dashboard (EPA)	DTXSID70188925 ;
ECHA InfoCard	100.020.536
Chemical and physical data
Formula	C11H15ClN2O2
Molar mass	242.70 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES Clc1ccc(OCC(=O)NNC(C)C)cc1;
	InChI InChI=1S/C11H15ClN2O2/c1-8(2)13-14-11(15)7-16-10-5-3-9(12)4-6-10/h3-6,8,13H,7H2,1-2H3,(H,14,15) ; Key:GGECDTUJZOXAAR-UHFFFAOYSA-N ;
	(verify)

Last updated June 10, 2025

Iproclozide (trade names Sursum, Sinderesin) is an irreversible and selective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant, but has since been discontinued.^[2] It has been known to cause fulminant hepatitis and there have been at least three reported fatalities due to administration of the drug.^[3]^[4]

References

↑ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
↑ Suerinck A, Suerinck E (April 1966). "[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]". Journal de Médecine de Lyon. 47 (96): 573–586. PMID 5930723.
↑ Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP (September 1978). "Iproclozide fulminant hepatitis. Possible role of enzyme induction". Gastroenterology. 75 (3): 492–496. doi: 10.1016/0016-5085(78)90856-9 . PMID 680506.
↑ Kaplowitz N, DeLeve LD (2003). Drug-induced liver disease. Informa Health Care. p. 455. ISBN 0-8247-0811-3.

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[pmid5930723-2] Suerinck A, Suerinck E (April 1966). "[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]". Journal de Médecine de Lyon. 47 (96): 573–586. PMID 5930723.

[pmid680506-3] Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP (September 1978). "Iproclozide fulminant hepatitis. Possible role of enzyme induction". Gastroenterology. 75 (3): 492–496. doi: 10.1016/0016-5085(78)90856-9 . PMID 680506.

[bookDrug-induced_liver_disease-4] Kaplowitz N, DeLeve LD (2003). Drug-induced liver disease. Informa Health Care. p. 455. ISBN 0-8247-0811-3.

[1]

[2]

[3]

[4]

v t e Anxiolytics (N05B)
5-HT_1AR Tooltip 5-HT1A receptor agonists	Buspirone Gepirone Tandospirone
GABA_AR Tooltip GABAA receptor PAMs Tooltip positive allosteric modulators	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam ^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam ^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem ^‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Carisoprodol Chlormezanone ^‡ Ethanol (alcohol) Etifoxine
Hypnotics	Zopiclone
Gabapentinoids (α₂δVDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIs Tooltip Selective serotonin reuptake inhibitors (e.g., escitalopram) SNRIs Tooltip Serotonin-norepinephrine reuptake inhibitors (e.g., duloxetine) SARIs Tooltip Serotonin antagonist and reuptake inhibitors (e.g., trazodone) TCAs Tooltip Tricyclic antidepressants (e.g., clomipramine ^#) TeCAs Tooltip Tetracyclic antidepressants (e.g., mirtazapine) MAOIs Tooltip Monoamine oxidase inhibitors (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Antipsychotics	Quetiapine Flupentixol
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol)
Others	Benzoctamine Cycloserine Fabomotizole Hydroxyzine Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane ^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^# WHO-EM ^‡ Withdrawn from market Clinical trials: ^† Phase III ^§Never to phase III

Clinical data

Routes of administration	Oral
ATC code	N06AF06 ( WHO )
Legal status
Legal status	BR: Class C1 (Other controlled substances)^[1] In general: uncontrolled
Identifiers
IUPAC name 2-(4-chlorophenoxy)-N-isopropyl-acetohydrazide
CAS Number	3544-35-2 ^Y
PubChem CID	19063
ChemSpider	17998 ^Y
UNII	1II9D6CB3J
KEGG	D07338 ^Y
ChEMBL	ChEMBL91238 ^Y
CompTox Dashboard (EPA)	DTXSID70188925
ECHA InfoCard	100.020.536
Chemical and physical data
Formula	C₁₁H₁₅ClN₂O₂
Molar mass	242.70 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc1ccc(OCC(=O)NNC(C)C)cc1
InChI InChI=1S/C11H15ClN2O2/c1-8(2)13-14-11(15)7-16-10-5-3-9(12)4-6-10/h3-6,8,13H,7H2,1-2H3,(H,14,15)^Y Key:GGECDTUJZOXAAR-UHFFFAOYSA-N^Y
(verify)

Iproclozide

See also

References