Pildralazine

Pildralazine

Clinical data
Other names	ISF-2123
Routes of administration	Oral
ATC code	None
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 1-[(6-Hydrazinylpyridazin-3-yl)(methyl)amino]propan-2-ol
CAS Number	64000-73-3
PubChem CID	68829
ChemSpider	62062
UNII	FU2BGC781U
CompTox Dashboard (EPA)	DTXSID7043746
Chemical and physical data
Formula	C8H15N5O
Molar mass	197.242 g·mol−1
3D model (JSmol)	Interactive image
SMILES n1nc(NN)ccc1N(C)CC(O)C
InChI InChI=1S/C8H15N5O/c1-6(14)5-13(2)8-4-3-7(10-9)11-12-8/h3-4,6,14H,5,9H2,1-2H3,(H,10,11) Key:KYIAWOXNPBANEW-UHFFFAOYSA-N

Pildralazine (Atensil), also known as propyldazine or propildazine, is an antihypertensive and vasodilator. ^[1]

Synthesis

Thieme Synthesis: Patent:

The reaction between 3,6-Dichloropyridazine [141-30-0] (1) and 1-(Methylamino)-2-propanol [16667-45-1] (2) gives CID:12237595 (3). Reaction with hydrazine completes the synthesis of Pidralazine (4).

References

1. Ganellin CR, Triggle DJ, Macdonald F (1997). Dictionary of pharmacological agents. CRC Press. p. 1603. ISBN   978-0-412-46630-4 . Retrieved 25 November 2011.
2. Pifferi G, Parravicini F, Carpi C, Dorigotti L (July 1975). "Synthesis and antihypertensive properties of new 3-hydrazinopyridazine derivatives". Journal of Medicinal Chemistry. 18 (7): 741–746. doi:10.1021/jm00241a020. PMID   1151996.
3. DE2154245 idem G Pifferi, U.S. patent 3,769,278 (1973 to Isf Spa).