Sercloremine

Sercloremine

Names
Preferred IUPAC name 4-(5-Chloro-1-benzofuran-2-yl)-1-methylpiperidine
Identifiers
CAS Number	54403-19-9  Y
3D model (JSmol)	Interactive image
ChemSpider	142884
PubChem CID	162749
UNII	8H340QZ35T  Y
CompTox Dashboard (EPA)	DTXSID601029766
InChI InChI=1S/C14H16ClNO/c1-16-6-4-10(5-7-16)14-9-11-8-12(15)2-3-13(11)17-14/h2-3,8-10H,4-7H2,1H3 Key: FTKTZRKAVSDSRA-UHFFFAOYSA-N
SMILES CN1CCC(CC1)C2=CC3=C(O2)C=CC(=C3)Cl
Properties
Chemical formula	C14H16ClNO
Molar mass	249.74 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Sercloremine (CGP-4718A), usually as the hydrochloride salt, is a drug which was developed in the 1980s and was formerly under investigation as an antidepressant, but was never marketed. ^{[1] [2]} It acts as a selective, reversible inhibitor of monoamine oxidase A (RIMA) and serotonin reuptake inhibitor. ^{[1] [3]}

References

1. Luttinger D, Hlasta DJ (January 1987). "Antidepressant agents". In Hesp B, Bailey DM (eds.). Annual Reports in Medicinal Chemistry. Vol. 22. Academic Press. pp. 21–30 (25). ISBN   978-0-08-058366-2.
2. Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1801–. ISBN   978-0-412-46630-4.
3. Delini-Stula A, Fischbach R, Gnirss F, Bures E, Pöldinger W (1985). "Early experience with CGP 4718 A (Sercloremine), a new selective and reversible MAO-A and 5-HT-uptake inhibitor, in the treatment of depressive patients". Drug Development Research. 6 (4): 371–384. doi:10.1002/ddr.430060409. ISSN   0272-4391. S2CID   85113482.