Metanephrine

Last updated
Metanephrine
3-Methoxyadrenalin Structural Formulae V.1.svg
Names
IUPAC name
4-(1-hydroxy-2-methylamino-ethyl)-2-methoxy-phenol
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
MeSH Metanephrine
PubChem CID
UNII
  • InChI=1S/C10H15NO3/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2/h3-5,9,11-13H,6H2,1-2H3 Yes check.svgY
    Key: JWJCTZKFYGDABJ-UHFFFAOYSA-N Yes check.svgY
  • InChI=1/C10H15NO3/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2/h3-5,9,11-13H,6H2,1-2H3
    Key: JWJCTZKFYGDABJ-UHFFFAOYAB
  • Oc1ccc(cc1OC)C(O)CNC
Properties
C10H15NO3
Molar mass 197.231 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Metanephrine, also known as metadrenaline, is a metabolite of epinephrine (also known as adrenaline) created by action of catechol-O-methyl transferase on epinephrine. An article in the Journal of the American Medical Association , 2002, indicated that the measurement of plasma free levels of the metanephrines group of molecules (including metanephrine and normetanephrine) is the best tool in the diagnosis of pheochromocytoma, an adrenal medullary neoplasm. [1]

References

  1. ↑ Lenders J, Pacak K, Walther M, Linehan W, Mannelli M, Friberg P, Keiser H, Goldstein D, Eisenhofer G (2002). "Biochemical diagnosis of pheochromocytoma: which test is best?". JAMA. 287 (11): 1427–34. doi: 10.1001/jama.287.11.1427 . PMID   11903030. Free full text with registration


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