Perafensine

Perafensine

Clinical data
Other names	HR-459
ATC code	None
Legal status
Legal status	Abandoned
Identifiers
IUPAC name 1-phenyl-3-(1-piperazinyl)isoquinoline
CAS Number	72444-62-3
PubChem CID	3047830
ChemSpider	2310140
UNII	WU6989IN6X
CompTox Dashboard (EPA)	DTXSID40222744
Chemical and physical data
Formula	C19H19N3
Molar mass	289.382 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1ccc(cc1)c2c3ccccc3cc(n2)N4CCNCC4
InChI InChI=1S/C19H19N3/c1-2-6-15(7-3-1)19-17-9-5-4-8-16(17)14-18(21-19)22-12-10-20-11-13-22/h1-9,14,20H,10-13H2 Key:BHHDTFRLKOTSKW-UHFFFAOYSA-N

Perafensine (INN; development code HR-459) is a drug which was investigated as an antidepressant but was never marketed. ^[1] It has been reported to antagonize the effects of reserpine and to inhibit the reuptake of norepinephrine (norepinephrine reuptake inhibitor); whether it also affects the reuptake of serotonin or dopamine is unclear. ^[2]

See also

• Diclofensine
• Nomifensine

References

1. Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1585–. ISBN   978-0-412-46630-4.
2. Bondinell W, Kaiser C (1982). Chapter 5. Antidepressants. Annual Reports in Medicinal Chemistry. Vol. 17. pp. 41–50. doi:10.1016/S0065-7743(08)60487-X. ISBN   9780120405176.