6-Nitroquipazine

6-Nitroquipazine

Clinical data
ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 6-nitro-2-piperazin-1-yl-quinoline
CAS Number	77372-73-7  N
PubChem CID	5012
ChemSpider	4837  Y
UNII	28M0X094BH
ChEMBL	ChEMBL41140  Y
CompTox Dashboard (EPA)	DTXSID7044001
Chemical and physical data
Formula	C13H14N4O2
Molar mass	258.281 g·mol−1
3D model (JSmol)	Interactive image
SMILES [O-][N+](=O)c3cc1c(nc(cc1)N2CCNCC2)cc3
InChI InChI=1S/C13H14N4O2/c18-17(19)11-2-3-12-10(9-11)1-4-13(15-12)16-7-5-14-6-8-16/h1-4,9,14H,5-8H2 Y Key:GGDBEAVVGFNWIA-UHFFFAOYSA-N Y
NY  (what is this?)    (verify)

6-Nitroquipazine (developmental code name DU-24,565) is a potent and selective serotonin reuptake inhibitor used in scientific research. ^{[1] [2]}

6-Nitroquipazine has been found to inhibit melanogenesis in-vitro , ^[3] suggesting that it can be used for skin whitening.

See also

• Quipazine

References

1. Vaatstra WJ, Deiman-Van Aalst WM, Eigeman L (March 1981). "Du 24565, a quipazine derivative, a potent selective serotonin uptake inhibitor". European Journal of Pharmacology. 70 (2): 195–202. doi:10.1016/0014-2999(81)90214-4. PMID   6973481.
2. Classen K, Göthert M, Schlicker E (June 1984). "Effects of DU 24565 (6-nitroquipazine) on serotoninergic and noradrenergic neurones of the rat brain and comparison with the effects of quipazine". Naunyn-Schmiedeberg's Archives of Pharmacology. 326 (3): 198–202. doi:10.1007/bf00505318. PMID   6206407. S2CID   20858707.
3. McEwan M, Parsons PG (July 1987). "Inhibition of melanization in human melanoma cells by a serotonin uptake inhibitor". The Journal of Investigative Dermatology. 89 (1): 82–86. doi: 10.1111/1523-1747.ep12580425 . PMID   3110297.No-cost access but non-free license.