Clofenciclan

Last updated

Clofenciclan
Clofenciclan.svg
Clinical data
Trade names Tonquil, Vesitan
Other namesChlorphencyclan
Routes of
administration 		Oral
ATC code
  • none
Identifiers
  • 2-[1-(4-chlorophenyl)cyclohexyl]oxy-N,N-diethylethanamine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C18H28ClNO
Molar mass 309.88 g·mol−1
3D model (JSmol)
  • ClC1=CC=C(C2(CCCCC2)OCCN(CC)CC)C=C1
  • InChI=1S/C18H28ClNO/c1-3-20(4-2)14-15-21-18(12-6-5-7-13-18)16-8-10-17(19)11-9-16/h8-11H,3-7,12-15H2,1-2H3 Yes check.svgY
  • Key:FFCARBNHUSWRGK-UHFFFAOYSA-N Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Clofenciclan (also known as chlorphencyclan; trade names Tonquil and Vesitan) is a dopamine-releasing agent developed by Boehringer & Soehne in the 1950s. [1] [2] It proved unpopular as a treatment because of its pronounced stimulant activity. [3]

Sila analogues of clorphencyclane were developed. [4]

See also

References

  1. ↑ Stach K, Winter W (January 1962). "[New therapeutically active basic ethers. 1. 1-Arylcycloalkanol derivatives]". Arzneimittel-Forschung. 12: 25–29. PMID   13916036.
  2. ↑ US 3254083,Stach K, Friesewinkel HA, Kroneberg HG, Stoepel K, Winter W,"[1-(Monocarbocyclic aryl)-cycloalkyl]-[(tertiaryamino)-lower alkyl] ethers",issued 31 May 1966, assigned to Roche Diagnostics GmbH
  3. ↑ Poeldinger W (January 1962). "[Therapeutic experiences with thiopropazate and with a combination of thiopropazate and chlorphencyclan (Vesitan) in psychiatry]". Praxis (in German). 51: 73–78. PMID   14487367.
  4. ↑ Ackermann J, Tacke R, Wannagat U, Koke U, Meyer F (1980). "Sila drugs, XII: Sila analogues of clorphencyclane (Author's transl)". Archiv der Pharmazie. 313 (2): 129–141. doi:10.1002/ardp.19803130206. PMID   7369832.


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