PEPA (drug)

PEPA

Clinical data
Other names	PEPA
Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}thio)phenoxy]acetamide
CAS Number	141286-78-4  Y
PubChem CID	6603828
ChemSpider	5036138  N
UNII	8S4PR7A8JS
CompTox Dashboard (EPA)	DTXSID60424960
Chemical and physical data
Formula	C16H16F2N2O4S2
Molar mass	402.43 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C=C1)S(=O)(=O)NCCSC2=CC(=C(C(=C2)F)OCC(=O)N)F
NY  (what is this?)    (verify)

PEPA is a sulfonamide AMPA receptor positive allosteric modulator, ^{[1] [2]} which is up to 100 times more potent than aniracetam in vitro. ^[3] It produces memory-enhancing effects in rats when administered intravenously. ^[4]

See also

• AMPA receptor positive allosteric modulator

References

1. Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, et al. (April 1998). "Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures". British Journal of Pharmacology. 123 (7): 1294–303. doi:10.1038/sj.bjp.0701707. PMC   1565288 . PMID   9579722.
2. Sekiguchi M, Nishikawa K, Aoki S, Wada K (August 2002). "A desensitization-selective potentiator of AMPA-type glutamate receptors". British Journal of Pharmacology. 136 (7): 1033–41. doi:10.1038/sj.bjp.0704804. PMC   1573432 . PMID   12145103.
3. Sekiguchi M, Fleck MW, Mayer ML, Takeo J, Chiba Y, Yamashita S, Wada K (August 1997). "A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide". The Journal of Neuroscience. 17 (15): 5760–71. doi:10.1523/JNEUROSCI.17-15-05760.1997. PMC   6573208 . PMID   9221774.
4. Sekiguchi M, Yamada K, Jin J, Hachitanda M, Murata Y, Namura S, et al. (September 2001). "The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment". NeuroReport. 12 (13): 2947–50. doi:10.1097/00001756-200109170-00038. PMID   11588608. S2CID   42785890.