ACEA-1328

ACEA-1328

Names
IUPAC name 6,7-dimethyl-5-nitro-1,4-dihydroquinoxaline-2,3-dione
Identifiers
CAS Number	160954-05-2  N[ ???? ]
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL41460
ChemSpider	7991843
PubChem CID	9816093
InChI InChI=1S/C10H9N3O4/c1-4-3-6-7(8(5(4)2)13(16)17)12-10(15)9(14)11-6/h3H,1-2H3,(H,11,14)(H,12,15) Key: CYJRVSOLVYLORV-UHFFFAOYSA-N
SMILES CC1=CC2=C(C(=C1C)[N+](=O)[O-])NC(=O)C(=O)N2
Properties
Chemical formula	C10H9N3O4
Molar mass	235.199 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

ACEA-1328 is an NMDA receptor antagonist.

Pharmacodynamics

ACEA-1328 acts as an antagonist of the glycine site at the NMDA receptor. ^[1]

Effects

Opioid tolerance

A study on mice has shown that ACEA-1328 was able to increase the analgesic action of morphine. It was also shown that it can reduce the formation of tolerance to morphine. ^[2]

Cocaine overdose

ACEA-1328 (along with other drugs) has been shown to be able to reduce convulsions induced by a cocaine overdose. ^{[3] [4]}

References

1. Lutfy, K.; Doan, P.; Nguyen, M.; Weber, E. (1999-11-12). "Effects of ACEA-1328, a NMDA receptor/glycine site antagonist, on U50,488H-induced antinociception and tolerance". European Journal of Pharmacology. 384 (1): 1–5. doi:10.1016/s0014-2999(99)00622-6. ISSN   0014-2999. PMID   10611412.
2. Lutfy, K.; Doan, P.; Weber, E. (November 1999). "ACEA-1328, a NMDA receptor/glycine site antagonist, acutely potentiates antinociception and chronically attenuates tolerance induced by morphine". Pharmacological Research. 40 (5): 435–442. doi:10.1006/phrs.1999.0538. ISSN   1043-6618. PMID   10527659.
3. Matsumoto, R. R.; Brackett, R. L.; Kanthasamy, A. G. (1997-11-12). "Novel NMDA/glycine site antagonists attenuate cocaine-induced behavioral toxicity". European Journal of Pharmacology. 338 (3): 233–242. doi:10.1016/s0014-2999(97)81926-7. ISSN   0014-2999. PMID   9424017.
4. Brackett, R. L.; Pouw, B.; Blyden, J. F.; Nour, M.; Matsumoto, R. R. (2000-01-28). "Prevention of cocaine-induced convulsions and lethality in mice: effectiveness of targeting different sites on the NMDA receptor complex". Neuropharmacology. 39 (3): 407–418. doi:10.1016/s0028-3908(99)00151-3. ISSN   0028-3908. PMID   10698007.