Carprofen

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Carprofen
Carprofen.svg
Carprofen molecule
Clinical data
AHFS/Drugs.com FDA Professional Drug Information
Routes of
administration 		Oral, injection
ATCvet code
Legal status
Legal status
  • US:Veterinary use only [1]
Pharmacokinetic data
Protein binding High (99%)
Elimination half-life Approximately 8 h (range 4.5–9.8 h) in dogs
Identifiers
  • (RS)-2-(6-Chloro-9H-carbazol-2-yl)propanoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
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ECHA InfoCard 100.053.357 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C15H12ClNO2
Molar mass 273.72 g·mol−1
3D model (JSmol)
Chirality Racemic mixture
  • CC(C1=CC=C2C(NC3=CC=C(C=C32)Cl)=C1)C(O)=O
  • InChI=1S/C15H12ClNO2/c1-8(15(18)19)9-2-4-11-12-7-10(16)3-5-13(12)17-14(11)6-9/h2-8,17H,1H3,(H,18,19) Yes check.svgY
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A 100 mg Rimadyl tablet approximately 19 mm (0.75 in) wide by 8.6 mm (0.34 in) thick, as sold in the USA. Rimadyl pill 100 mg.jpg
A 100  mg Rimadyl tablet approximately 19  mm (0.75  in ) wide by 8.6 mm (0.34 in) thick, as sold in the USA.

Carprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the carbazole and propionic acid class that was previously for use in humans and animals but is now only available to veterinarians for prescribing as a supportive treatment for various conditions in animals. [1] Carprofen reduces inflammation by inhibition of COX-1 and COX-2; its specificity for COX-2 varies from species to species. [1] Marketed under many brand names worldwide, [2] carprofen is used as a treatment for inflammation and pain, including joint pain and postoperative pain. [1]

Contents

Human use

Carprofen was used in humans for almost ten years, starting in 1988, for the same conditions as in dogs; namely, joint pain and inflammation. Side effects tended to be mild, usually consisting of nausea or gastrointestinal pain and diarrhoea. It was available by prescription in 150  mg to 600 mg doses. [3] Dosages over 250 mg were reserved for pain caused by severe trauma, such as postoperative inflammation; 150 mg doses were commonly used to relieve arthritis pain, while 200 mg doses were commonly prescribed for severe arthritis or inflammatory pain. The drug was taken orally.

Pfizer voluntarily removed the medication from the market for human use on commercial grounds. [3]

Veterinary medicine

Canine use

Carprofen is one of eleven nonsteroidal anti-inflammatory drugs approved for use in dogs. [4] It aids in the relief of inflammation, pain, and fever. Carprofen can be administered in pill, chewable tablet, or injection form. [5]

Carprofen can be used for long-term pain management of such conditions as osteoarthritis, which is common in canine patients, or after surgical procedures for relief of acute pain and inflammation. [5] [6]

In patients suffering from pain, carprofen has been shown to improve energy, activity level, comfort, and general well-being. [6]

Adverse effects

Most dogs respond well to carprofen use, but like all NSAIDs, it can cause gastrointestinal, liver, and kidney problems. [7]

In 1999, the Food and Drug Administration (FDA) received more than six thousand anecdotal reports of sudden animal death after usage of Pfizer's Rimadyl brand of carprofen. In response, the FDA requested that Pfizer advise consumers in their advertising that death is a possible side effect; [8] Pfizer refused and pulled their advertising, later including death as a possible side effect on the drug label. [9]

Adverse effects can include:

Effects of overdose include gastritis and ulcer formation. [13]

In healthy dogs given carprofen, no perioperative adverse effects on the cardiovascular system have been reported at recommended dosages. [14] [15] Perioperative administration of carprofen to cats did not affect postoperative respiratory rate nor heart rate. [16]

Carprofen should not be administered concurrently with steroids, as this can cause ulcers in the stomach. Dogs should be taken off carprofen for three full days before ingesting a steroid (such as prednisolone). Carprofen should not be given at the same time with other types of medications, such as other NSAIDs (aspirin, etodolac, deracoxib, meloxicam, tepoxalin), or steroids such as dexamethasone, triamcinolone, cortisone, or prednisone.[ medical citation needed ]

Carprofen must be used with caution within the supervision of a veterinarian in dogs with liver or kidney disease, dehydration, bleeding deficits, or other health problems. It is not recommended for use in dogs with bleeding disorders (such as Von Willebrand's disease), as safety has not been established in dogs with these disorders. [17] It has not been established whether carprofen can be safely used in pregnant dogs, dogs used for breeding purposes, or in lactating dogs.

Several laboratory studies and clinical trials have been conducted to establish the safety of using carprofen. Clinical studies were conducted in nearly 300 dogs of different breeds. The dogs were treated with Rimadyl at the recommended dose for two weeks. According to these studies, the drug was clinically well tolerated, and the treated dogs did not have a greater incidence of adverse reactions when compared to the control group. [18] [ medical citation needed ]

A number of factors may contribute to the high incidence of adverse reports received for carprofen by the Center for Veterinary Medicine in the late 1990s. These include:

  • The type of drug;
  • Wide use;
  • Duration of use. Long-term use can result in a higher risk for adverse reactions. It is recommended that blood tests for liver and kidney function are performed both prior to starting and regularly while on NSAIDs to monitor the patient’s tolerance; [19]
  • Senior dog use. Older dogs are generally more prone to side effects caused by carprofen.[ medical citation needed ]

Equine use

Carprofen may be administered intravenously to horses. [20] A single dose has been shown to reduce prostaglandin E2 production and inflammatory exudate for up to 15 hours, [21] although there was less effect on eicosanoid production when compared to the effects produced by NSAIDs such as phenylbutazone or flunixin. [22] Prostaglandin E2 and inflammatory exudate are also reduced and leukotriene B4 is inhibited. Carprofen can also be given orally, but intramuscular use may produce muscle damage. [23]

Other animal use

Carprofen is used as an analgesic for mouse surgical procedures. [24] Carprofen may also be used on adult fish. [25]

Brands and dosage forms for veterinary use

It is marketed under many brand names including: Acticarp, Artriofin, Austiofen, Bomazeal, Canidryl, Carporal, Carprieve, Carprocow, Carprodolor, Carprodyl, Carprofelican, Carprofen, Carprofène, Carprofeno, Carprofenum, Carprogesic, Carprosol, Carprotab, Carprox, Comforion, Dolagis, Dolocarp, Dolox, Eurofen, Kelaprofen, Librevia, Norocarp, Norodyl, Novocox, Ostifen, Prolet, Quellin, Reproval, Rimadyl, Rimifin, Rofeniflex, Rovera, Rycarfa, Scanodyl, Tergive, Vetprofen, and Xelcor. [2]

Veterinary dosage forms include 25  mg, 75 mg, and 100 mg tablets, and 50 mg per mL injectable form. [1] [26] and more recent a 50 mg Caplet called Carprox for senior dogs aged 10 years+.

Related Research Articles

<span class="mw-page-title-main">Ketoprofen</span> NSAID analgesic medication

Ketoprofen is one of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAID) with analgesic and antipyretic effects. It acts by inhibiting the body's production of prostaglandin.

<span class="mw-page-title-main">Nonsteroidal anti-inflammatory drug</span> Class of therapeutic drug for relieving pain and inflammation

Non-steroidal anti-inflammatory drugs (NSAID) are members of a therapeutic drug class which reduces pain, decreases inflammation, decreases fever, and prevents blood clots. Side effects depend on the specific drug, its dose and duration of use, but largely include an increased risk of gastrointestinal ulcers and bleeds, heart attack, and kidney disease.

<span class="mw-page-title-main">Ibuprofen</span> Medication treating pain, fever, and inflammation

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, fever, and inflammation. This includes painful menstrual periods, migraines, and rheumatoid arthritis. It may also be used to close a patent ductus arteriosus in a premature baby. It can be used orally or intravenously. It typically begins working within an hour.

<span class="mw-page-title-main">Diclofenac</span> Nonsteroidal anti-inflammatory drug

Diclofenac, sold under the brand name Voltaren, among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. It is taken by mouth or rectally in a suppository, used by injection, or applied to the skin. Improvements in pain last for as much as eight hours. It is also available in combination with misoprostol in an effort to decrease stomach problems.

<span class="mw-page-title-main">Phenylbutazone</span> Nonsteroidal anti-inflammatory drug (NSAID)

Phenylbutazone, often referred to as "bute", is a nonsteroidal anti-inflammatory drug (NSAID) for the short-term treatment of pain and fever in animals.

Cyclooxygenase-2 inhibitors, also known as coxibs, are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly target cyclooxygenase-2 (COX-2), an enzyme responsible for inflammation and pain. Targeting selectivity for COX-2 reduces the risk of peptic ulceration and is the main feature of celecoxib, rofecoxib, and other members of this drug class.

<span class="mw-page-title-main">Oxaprozin</span> Chemical compound

Oxaprozin, also known as oxaprozinum, is a nonsteroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative. Safety and efficacy has been established in children over 6 years with juvenile rheumatoid arthritis only, and there is an increased risk of adverse reactions in the elderly population.

<span class="mw-page-title-main">Meloxicam</span> Nonsteroidal anti-inflammatory drug (NSAID)

Meloxicam, sold under the brand name Mobic among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation in rheumatic diseases and osteoarthritis. It is used by mouth or by injection into a vein. It is recommended that it be used for as short a period as possible and at a low dose.

<span class="mw-page-title-main">Ketorolac</span> Nonsteroidal anti-inflammatory drug (NSAID; analgesic)

Ketorolac, sold under the brand name Toradol among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain. Specifically it is recommended for moderate to severe pain. Recommended duration of treatment is less than six days, and in Switzerland not more than two days. It is used by mouth, by nose, by injection into a vein or muscle, and as eye drops. Effects begin within an hour and last for up to eight hours.

<span class="mw-page-title-main">Etodolac</span> Nonsteroidal anti-inflammatory drug

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID).

<span class="mw-page-title-main">Flunixin</span> NSAID analgesic veterinary drug

Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic used in horses, cattle and pigs. It is often formulated as the meglumine salt. In the United States, it is regulated by the U.S. Food and Drug Administration (FDA), and may only be lawfully distributed by order of a licensed veterinarian. There are many trade names for the product.

<span class="mw-page-title-main">Diflunisal</span> NSAID analgesic and anti-inflammatory drug

Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. It was developed by Merck Sharp & Dohme in 1971, as MK647, after showing promise in a research project studying more potent chemical analogs of aspirin. It was first sold under the brand name Dolobid, marketed by Merck & Co., but generic versions are now widely available. It is classed as a nonsteroidal anti-inflammatory drug (NSAID) and is available in 250 mg and 500 mg tablets.

<span class="mw-page-title-main">Nabumetone</span> NSAID analgesic and anti-inflammatory drug

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<span class="mw-page-title-main">Deracoxib</span> NSAID analgesic veterinary drug

Deracoxib is a nonsteroidal anti-inflammatory drug (NSAID) of the coxib class, used in dogs to treat pain associated with osteoarthritis, or to prevent pain following orthopedic or dental surgery. It is available as beef-flavored tablets.

<span class="mw-page-title-main">Tepoxalin</span> NSAID anti-inflammatory veterinary drug

Tepoxalin, sold under the brand name Zubrin among others, is a non-steroidal anti-flammatory drug (NSAIDs) generally used in veterinary medicine to reduce swelling in animals with osteoarthritis. In rare circumstances, tepoxalin can also be used in human pharmacology to relieve pain caused by musculoskeletal conditions such as arthritis and hip dysplasia.

<span class="mw-page-title-main">Meclofenamic acid</span> Chemical compound

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<span class="mw-page-title-main">Fenoprofen</span> NSAID analgesic and anti-inflammatory drug

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<span class="mw-page-title-main">Grapiprant</span> NSAID anti-inflammatory veterinary drug

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Prostaglandin inhibitors are drugs that inhibit the synthesis of prostaglandin in human body. There are various types of prostaglandins responsible for different physiological reactions such as maintaining the blood flow in stomach and kidney, regulating the contraction of involuntary muscles and blood vessels, and act as a mediator of inflammation and pain. Cyclooxygenase (COX) and Phospholipase A2 are the major enzymes involved in prostaglandin production, and they are the drug targets for prostaglandin inhibitors. There are mainly 2 classes of prostaglandin inhibitors, namely non- steroidal anti- inflammatory drugs (NSAIDs) and glucocorticoids. In the following sections, the medical uses, side effects, contraindications, toxicity and the pharmacology of these prostaglandin inhibitors will be discussed.

References

  1. 1 2 3 4 5 "Rimadyl (carprofen) prescribing information leaflet" (PDF). www2.ZoetisUS.com. Zoetis Inc. Retrieved 5 February 2022.
  2. 1 2 "International brand names for Carprofen". www.Drugs.com. Drugs.com . Retrieved 4 October 2017.
  3. 1 2 "Committee for Veterinary Medicinal Products: Carprofen" (PDF). www.EMA.Europa.eu. European Agency for the Evaluation of Medicinal Products. 2009.
  4. ↑ "Animal Drugs @ FDA - NSAID labels". AnimalDrugsAtFDA.FDA.gov. US FDA . Retrieved 16 November 2021.
  5. 1 2 Burke A (10 November 2016). "Rimadyl for Dogs – uses, side effects & alternatives". www.AKC.org. American Kennel Club . Retrieved 16 November 2021.
  6. 1 2 "Rimadyl". www.ZoetisPetCare.com. Retrieved 16 November 2021.
  7. ↑ Reimer ME, Johnston SA, Leib MS, Duncan RB, Reimer DC, Marini M, Gimbert K (September 1999). "The gastroduodenal effects of buffered aspirin, carprofen, and etodolac in healthy dogs". Journal of Veterinary Internal Medicine. 13 (5): 472–477. doi: 10.1111/j.1939-1676.1999.tb01465.x . PMID   10499732.
  8. ↑ "Update on Rimadyl". www.FDA.gov. FDA's Center for Veterinary Medicine. 1 December 1999. Archived from the original on 8 September 2014. Retrieved 16 December 2019.
  9. ↑ Luna SP, Basílio AC, Steagall PV, Machado LP, Moutinho FQ, Takahira RK, Brandão CV (March 2007). "Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs". American Journal of Veterinary Research. 68 (3): 258–264. doi: 10.2460/ajvr.68.3.258 . PMID   17331014.
  10. ↑ "A review of signs of a potentially life-threatening reaction to Rimadyl". www.srdogs.com. Retrieved 20 May 2010.
  11. ↑ "Dog owner information about Rimadyl (carprofen)". www.Rimadyl.com. Pfizer. Archived from the original on 15 July 2011. Retrieved 20 May 2010.
  12. ↑ "Carprofen For Dogs: Dosage, Side Effects, And Alternatives". Relievet. Retrieved 2022-07-21.
  13. ↑ "Generic dog Rimadyl online". RimadylOnline.com. Archived from the original on 15 July 2011. Retrieved 15 July 2011.
  14. ↑ Boström IM, Nyman GC, Lord PE, Häggström J, Jones BE, Bohlin HP (May 2002). "Effects of carprofen on renal function and results of serum biochemical and hematologic analyses in anesthetized dogs that had low blood pressure during anesthesia". American Journal of Veterinary Research. 63 (5): 712–721. doi: 10.2460/ajvr.2002.63.712 . PMID   12013473.
  15. ↑ Frendin JH, Boström IM, Kampa N, Eksell P, Häggström JU, Nyman GC (December 2006). "Effects of carprofen on renal function during medetomidine-propofol-isoflurane anesthesia in dogs". American Journal of Veterinary Research. 67 (12): 1967–1973. doi: 10.2460/ajvr.67.12.1967 . PMID   17144795.
  16. ↑ Höglund OV, Dyall B, Gräsman V, Edner A, Olsson U, Höglund K (October 2018). "Effect of non-steroidal anti-inflammatory drugs on postoperative respiratory and heart rate in cats subjected to ovariohysterectomy". Journal of Feline Medicine and Surgery. 20 (10): 980–984. doi:10.1177/1098612X17742290. PMC   11129237 . PMID   29165006. S2CID   30649716.
  17. ↑ "Rimadyl (Carprofen)". www.VetDepot.com. Vet Depot. Archived from the original on 23 May 2010. Retrieved 20 May 2010.
  18. ↑ "Rimadyl [package insert]" (PDF). www.Rimadyl.com. New York: Pfizer Animal Health. 2007. Retrieved 13 August 2014.
  19. ↑ "Get the facts about pain relievers for pets". www.FDA.gov. Center for Veterinary Medicine. 3 November 2020.
  20. ↑ McIlwraith CW, Frisbie DD, Kawcak CE (2001). "Nonsteroidal Anti-Inflammatory Drugs". Proc. AAEP (47): 182–187.
  21. ↑ Lees P, McKellar Q, May SA, Ludwig B (May 1994). "Pharmacodynamics and pharmacokinetics of carprofen in the horse". Equine Veterinary Journal. 26 (3): 203–208. doi:10.1111/j.2042-3306.1994.tb04370.x. PMID   8542839.
  22. ↑ Lees P, Ewins CP, Taylor JB, Sedgwick AD (1987). "Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixin". The British Veterinary Journal. 143 (5): 462–476. doi:10.1016/0007-1935(87)90024-8. PMID   3119142.
  23. ↑ McKellar QA, Bogan JA, von Fellenberg RL, Ludwig B, Cawley GD (July 1991). "Pharmacokinetic, biochemical and tolerance studies on carprofen in the horse". Equine Veterinary Journal. 23 (4): 280–284. doi:10.1111/j.2042-3306.1991.tb03718.x. PMID   1915228.
  24. ↑ Adamson, Trinka (2010). "Assessment of Carprofen and Buprenorphine on Recovery of Mice after Surgical Removal of the Mammary Fat Pad". J Am Assoc Lab Anim Sci. 49 (5): 610–616. PMC   2949431 . PMID   20858363.
  25. ↑ Uney, Kamil (2021). "Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock". Pharmaceutics. 13 (7): 990. doi: 10.3390/pharmaceutics13070990 . PMC   8309133 . PMID   34208822.
  26. ↑ "Carprofen (Veterinary – Systemic)" (PDF). The United States Pharmacopeial Convention. 2007.

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