Glucametacin

Glucametacin
Clinical data
Trade names	Teoremac
Other names	Indometacin glucosamide
Identifiers
	IUPAC name 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-[(2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]acetamide;
CAS Number	52443-21-7 ;
PubChem CID	3033980 ;
ChemSpider	2298541 ;
UNII	N1EXE5EHAN ;
KEGG	D08021 ;
ChEMBL	ChEMBL488914 ;
CompTox Dashboard (EPA)	DTXSID80200445 ;
ECHA InfoCard	100.052.640
Chemical and physical data
Formula	C25H27ClN2O8
Molar mass	518.95 g·mol−1

Last updated January 03, 2026

Glucametacin is a non-steroidal anti-inflammatory drug used for the treatment of mild or moderate pain associated with rheumatoid arthritis, osteoarthritis, and other rheumatological disorders.^[1] It has analgesic and anti-inflammatory effects.^[1]^[2]^[3]

Glucametacin is an amide of indometacin with glucosamine.

References

1 2 Capelli L, Chianese V, La Montagna G, Giordano M (1981). "Further studies on glucametacin in rheumatoid arthritis and in other chronic types of rheumatism". Current Medical Research and Opinion. 7 (4): 227–233. doi:10.1185/03007998109114267. PMID 6971729.
↑ Akatsu T, Catanzaro Guimarães SA (1986). "Comparative effects of non-steroidal anti-inflammatory drugs, mefenamic acid, metiazinic acid and glucametacin on the inflammatory response induced by subcutaneous implantation of human dental plaque and on the mitotic activity of isoproterenol-stimulated parotid glands of rats". Cellular and Molecular Biology. 32 (5): 619–626. PMID 3779763.
↑ Ibba G, Uras R, Perpignano G (1983). "Double-blind comparison of glucametacin and ketoprofen in chronic arthropathies". Current Medical Research and Opinion. 8 (5): 321–326. doi:10.1185/03007998309112391. PMID 6340973.

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[Capelli-1] 1 2 Capelli L, Chianese V, La Montagna G, Giordano M (1981). "Further studies on glucametacin in rheumatoid arthritis and in other chronic types of rheumatism". Current Medical Research and Opinion. 7 (4): 227–233. doi:10.1185/03007998109114267. PMID 6971729.

[2] Akatsu T, Catanzaro Guimarães SA (1986). "Comparative effects of non-steroidal anti-inflammatory drugs, mefenamic acid, metiazinic acid and glucametacin on the inflammatory response induced by subcutaneous implantation of human dental plaque and on the mitotic activity of isoproterenol-stimulated parotid glands of rats". Cellular and Molecular Biology. 32 (5): 619–626. PMID 3779763.

[3] Ibba G, Uras R, Perpignano G (1983). "Double-blind comparison of glucametacin and ketoprofen in chronic arthropathies". Current Medical Research and Opinion. 8 (5): 321–326. doi:10.1185/03007998309112391. PMID 6340973.

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