Flumizole

Flumizole
Clinical data
ATC code	none;
Identifiers
	IUPAC name 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-1H-imidazole;
CAS Number	36740-73-5 ;
PubChem CID	37518 ;
ChemSpider	34419 ;
UNII	Y4YQF944N9 ;
KEGG	D04211 ;
ChEMBL	ChEMBL430150 ;
CompTox Dashboard (EPA)	DTXSID10190204 ;
Chemical and physical data
Formula	C18H15F3N2O2
Molar mass	348.325 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES FC(F)(F)c2[nH]c(c(c1ccc(OC)cc1)n2)c3ccc(OC)cc3;
	InChI InChI=1S/C18H15F3N2O2/c1-24-13-7-3-11(4-8-13)15-16(23-17(22-15)18(19,20)21)12-5-9-14(25-2)10-6-12/h3-10H,1-2H3,(H,22,23); Key:OPYFPDBMMYUPME-UHFFFAOYSA-N;

Last updated August 01, 2025

Flumizole is an antiinflammatory agent. More specifically, it is a nonsteroidal anti-inflammatory drug (NSAID) that acts via inhibition of the enzyme cyclooxygenase (COX).^[1]

References

↑ Wiseman EH, McIlhenny HM, Bettis JW (September 1975). "Flumizole, a new nonsteroidal anti-inflammatory agent". Journal of Pharmaceutical Sciences. 64 (9): 1469–75. Bibcode:1975JPhmS..64.1469M. doi:10.1002/jps.2600640909. PMID 810570.

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[1] Wiseman EH, McIlhenny HM, Bettis JW (September 1975). "Flumizole, a new nonsteroidal anti-inflammatory agent". Journal of Pharmaceutical Sciences. 64 (9): 1469–75. Bibcode:1975JPhmS..64.1469M. doi:10.1002/jps.2600640909. PMID 810570.

[1]

v t e Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
pyrazolones / pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone ^‡
salicylates	Aspirin (acetylsalicylic acid) ^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bufexamac Bumadizone Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Mofezolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac ^†
oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Pivoxicam Tenoxicam
propionic acid derivatives (profens)	Alminoprofen Benoxaprofen ^† Carprofen ^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen ^# Ibuproxam Indoprofen ^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pelubiprofen Piketoprofen Pirprofen Suprofen Tarenflurbil Tepoxalin ^‡ Tiaprofenic acid Vedaprofen ^‡ Zaltoprofen COX-inhibiting nitric oxide donator : Naproxcinod
n-arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Floctafenine Flufenamic acid Flunixin Flutiazin Glafenine ^† Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid
COX-2 inhibitors (coxibs)	Apricoxib Celecoxib (+tramadol) Cimicoxib ^‡ Deracoxib ^‡ Etoricoxib Firocoxib ^‡ Lumiracoxib ^† Mavacoxib ^‡ Parecoxib Robenacoxib ^‡ Rofecoxib ^† Valdecoxib ^†
other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase / orgotein Tenidap
NSAID combinations	Ibuprofen/famotidine Ibuprofen/hydrocodone Ibuprofen/oxycodone Ibuprofen/paracetamol Meloxicam/bupivacaine Meloxicam/rizatriptan Naproxen/diphenhydramine Naproxen/esomeprazole
Key: underline indicates initially developed first-in-class compound of specific group; ^# WHO-Essential Medicines; ^† withdrawn drugs; ^‡ veterinary use.
category commons portal

Clinical data

ATC code	none
Identifiers
IUPAC name 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-1H-imidazole
CAS Number	36740-73-5
PubChem CID	37518
ChemSpider	34419
UNII	Y4YQF944N9
KEGG	D04211
ChEMBL	ChEMBL430150
CompTox Dashboard (EPA)	DTXSID10190204
Chemical and physical data
Formula	C₁₈H₁₅F₃N₂O₂
Molar mass	348.325 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES FC(F)(F)c2[nH]c(c(c1ccc(OC)cc1)n2)c3ccc(OC)cc3
InChI InChI=1S/C18H15F3N2O2/c1-24-13-7-3-11(4-8-13)15-16(23-17(22-15)18(19,20)21)12-5-9-14(25-2)10-6-12/h3-10H,1-2H3,(H,22,23) Key:OPYFPDBMMYUPME-UHFFFAOYSA-N