Firocoxib

Last updated

Firocoxib
Firocoxib.svg
Firocoxib-3D-spacefill.png
Clinical data
Trade names Equioxx, Previcox
AHFS/Drugs.com
License data
Routes of
administration 		By mouth
ATCvet code
Legal status
Legal status
Identifiers
  • 3-(Cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C17H20O5S
Molar mass 336.40 g·mol−1
3D model (JSmol)
  • O=C2OC(C(=C2\OCC1CC1)\c3ccc(cc3)S(=O)(=O)C)(C)C
  • InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3 Yes check.svgY
  • Key:FULAPETWGIGNMT-UHFFFAOYSA-N Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Firocoxib, sold under the brand names Equioxx and Previcox among others, is a nonsteroidal anti-inflammatory drug of the COX-2 inhibitor (coxib) class, approved for use in horses (Equioxx) and for use in dogs (Previcox). [2] [4] [9] Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses. [10] Firocoxib is not intended or approved for use in human medicine. [2] [4] [5] [6] [11]

Firocoxib, manufactured by Merial, was approved for veterinary use in the United States for dogs in July 2004, [12] and for horses in July 2007, as an oral paste (Equioxx) and July 2016, as tablets. [13] [14]

Firocoxib is also available as a generic medication for horses [14] and for dogs. [12]

References

  1. ↑ "Product information". Health Canada . 22 October 2009. Retrieved 9 February 2024.
  2. 1 2 3 "Equioxx- firocoxib tablet, chewable". DailyMed. 14 July 2020. Archived from the original on 3 August 2022. Retrieved 2 August 2022.
  3. ↑ "Equioxx- firocoxib paste". DailyMed. 24 February 2022. Archived from the original on 3 August 2022. Retrieved 2 August 2022.
  4. 1 2 3 "Previcox- firocoxib tablet, chewable". DailyMed. 23 July 2020. Archived from the original on 3 August 2022. Retrieved 2 August 2022.
  5. 1 2 "Equioxx EPAR". European Medicines Agency (EMA). 30 June 2008. Archived from the original on 25 April 2022. Retrieved 2 August 2022.
  6. 1 2 "Previcox EPAR". European Medicines Agency (EMA). 16 March 2007. Archived from the original on 31 July 2021. Retrieved 2 August 2022.
  7. ↑ "Coxatab EPAR". European Medicines Agency (EMA). 17 June 2022. Retrieved 9 February 2024.
  8. ↑ "Previcox PI". Union Register of medicinal products. 15 September 2004. Retrieved 26 December 2024.
  9. ↑ Rangel-Nava A, Ramírez-Uribe JM, Recillas-Morales S, Ibancovichi-Camarillo JA, Venebra-Muñoz A, Sánchez-Aparicio P (June 2019). "Pharmacological Regulation in the USA and Pharmacokinetics Parameters of Firocoxib, a Highly Selective Cox-2, by Pain Management in Horses". Journal of Equine Veterinary Science. 77: 36–42. doi:10.1016/j.jevs.2019.02.007. PMID   31133314. S2CID   86530623.
  10. ↑ "New NSAID Equioxx (firocoxib) Approved by USEF". The Horse. 2 July 2007. Archived from the original on 18 May 2011. Retrieved 18 April 2008.
  11. ↑ Equioxx Archived 21 December 2014 at the Wayback Machine , European Medicines Agency (EMA)
  12. 1 2 "FDA Approves the First Generic Firocoxib Tablets for Dogs". U.S. Food and Drug Administration. 7 June 2022. Archived from the original on 3 August 2022. Retrieved 2 August 2022.
  13. ↑ "Merial launches first firocoxib for horses". DVM 360. 1 July 2007. Retrieved 3 October 2023.
  14. 1 2 "FDA Approves the First Generic Firocoxib Tablets for Horses". U.S. Food and Drug Administration (FDA). 1 August 2022. Archived from the original on 3 August 2022. Retrieved 2 August 2022.
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