Fourphit

Last updated
Fourphit
Fourphit.svg
Names
Preferred IUPAC name
4-Isothiocyanato-1-(1-phenylcyclohexyl)piperidine
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
UNII
  • InChI=1S/C18H24N2S/c21-15-19-17-9-13-20(14-10-17)18(11-5-2-6-12-18)16-7-3-1-4-8-16/h1,3-4,7-8,17H,2,5-6,9-14H2
    Key: QAHYIAVTWZVTMY-UHFFFAOYSA-N
  • InChI=1/C18H24N2S/c21-15-19-17-9-13-20(14-10-17)18(11-5-2-6-12-18)16-7-3-1-4-8-16/h1,3-4,7-8,17H,2,5-6,9-14H2
    Key: QAHYIAVTWZVTMY-UHFFFAOYAR
  • c1ccc(cc1)C2(CCCCC2)N3CCC(CC3)N=C=S
Properties
C18H24N2S
Molar mass 300.46 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Fourphit (4-isothiocyanato-1-[1-phenylcyclohexyl]piperidine) is a covalent binding NMDA antagonist, dopaminergic and sigma receptor agonist. [1]

See also

Related Research Articles

<span class="mw-page-title-main">BMW</span> German automotive brand, manufacturer, and conglomerate

Bayerische Motoren Werke AG, abbreviated as BMW, is a German multinational manufacturer of performance luxury vehicles and motorcycles headquartered in Munich, Bavaria, Germany. The corporation was founded in 1916 as a manufacturer of aircraft engines, which it produced from 1917 until 1918 and again from 1933 to 1945.

<span class="mw-page-title-main">Black hole</span> Astronomical object that has a no-return boundary

A black hole is a region of spacetime where gravity is so strong that nothing, including light or other electromagnetic waves, has enough energy to escape it. The theory of general relativity predicts that a sufficiently compact mass can deform spacetime to form a black hole. The boundary of no escape is called the event horizon. Although it has a great effect on the fate and circumstances of an object crossing it, it has no locally detectable features according to general relativity. In many ways, a black hole acts like an ideal black body, as it reflects no light. Moreover, quantum field theory in curved spacetime predicts that event horizons emit Hawking radiation, with the same spectrum as a black body of a temperature inversely proportional to its mass. This temperature is of the order of billionths of a kelvin for stellar black holes, making it essentially impossible to observe directly.

<span class="mw-page-title-main">Cat</span> Domesticated felid species

The cat is a domestic species of small carnivorous mammal. It is the only domesticated species in the family Felidae and is commonly referred to as the domestic cat or house cat to distinguish it from the wild members of the family. Cats are commonly kept as house pets but can also be farm cats or feral cats; the feral cat ranges freely and avoids human contact. Domestic cats are valued by humans for companionship and their ability to kill rodents. About 60 cat breeds are recognized by various cat registries.

<span class="mw-page-title-main">Earth</span> Third planet from the Sun

Earth is the third planet from the Sun and the only astronomical object known to harbor life. While large volumes of water can be found throughout the Solar System, only Earth sustains liquid surface water. About 71% of Earth's surface is made up of the ocean, dwarfing Earth's polar ice, lakes, and rivers. The remaining 29% of Earth's surface is land, consisting of continents and islands. Earth's surface layer is formed of several slowly moving tectonic plates, which interact to produce mountain ranges, volcanoes, and earthquakes. Earth's liquid outer core generates the magnetic field that shapes the magnetosphere of the Earth, deflecting destructive solar winds.

<span class="mw-page-title-main">ISO 8601</span> International standards for dates and times

ISO 8601 is an international standard covering the worldwide exchange and communication of date and time-related data. It is maintained by the Geneva-based International Organization for Standardization (ISO) and was first published in 1988, with updates in 1991, 2000, 2004, and 2019, and an amendment in 2022. The standard provides a well-defined, unambiguous method of representing calendar dates and times in worldwide communications, especially to avoid misinterpreting numeric dates and times when such data is transferred between countries with different conventions for writing numeric dates and times.

<span class="mw-page-title-main">M16 rifle</span> American assault rifle

The M16 rifle is a family of military rifles adapted from the ArmaLite AR-15 rifle for the United States military. The original M16 rifle was a 5.56×45mm automatic rifle with a 20-round magazine.

The International System of Units, known by the international abbreviation SI in all languages and sometimes pleonastically as the SI system, is the modern form of the metric system and based on the metre as the unit of length and either the kilogram as the unit of mass or the kilogram-force as the unit of force.</ref> and the world's most widely used system of measurement. Established and maintained by the General Conference on Weights and Measures (CGPM), it is the only system of measurement with an official status in nearly every country in the world, employed in science, technology, industry, and everyday commerce.

<span class="mw-page-title-main">Solar System</span> The Sun and objects orbiting it

The Solar System is the gravitationally bound system of the Sun and the objects that orbit it. It formed 4.6 billion years ago from the gravitational collapse of a giant interstellar molecular cloud. The vast majority (99.86%) of the system's mass is in the Sun, with most of the remaining mass contained in the planet Jupiter. The four inner system planets—Mercury, Venus, Earth and Mars—are terrestrial planets, being composed primarily of rock and metal. The four giant planets of the outer system are substantially larger and more massive than the terrestrials. The two largest, Jupiter and Saturn, are gas giants, being composed mainly of hydrogen and helium; the next two, Uranus and Neptune, are ice giants, being composed mostly of volatile substances with relatively high melting points compared with hydrogen and helium, such as water, ammonia, and methane. All eight planets have nearly circular orbits that lie near the plane of Earth's orbit, called the ecliptic.

<span class="mw-page-title-main">United States Army</span> Land service branch of the United States Armed Forces

The United States Army (USA) is the land service branch of the United States Armed Forces. It is one of the eight U.S. uniformed services, and is designated as the Army of the United States in the U.S. Constitution. The oldest and most senior branch of the U.S. military in order of precedence, the modern U.S. Army has its roots in the Continental Army, which was formed 14 June 1775 to fight the American Revolutionary War (1775–1783)—before the United States was established as a country. After the Revolutionary War, the Congress of the Confederation created the United States Army on 3 June 1784 to replace the disbanded Continental Army. The United States Army considers itself to be a continuation of the Continental Army, and thus considers its institutional inception to be the origin of that armed force in 1775.

<span class="mw-page-title-main">M1 Abrams</span> Current American main battle tank

The M1 Abrams is a third-generation American main battle tank designed by Chrysler Defense and named for General Creighton Abrams. Conceived for modern armored ground warfare and now one of the heaviest tanks in service at nearly 68 short tons, it introduced several modern technologies to US armored forces, including a multifuel turbine engine, sophisticated Chobham composite armor, a computer fire control system, separate ammunition storage in a blow-out compartment, and NBC protection for crew safety. Initial models of the M1 were armed with a licensed-produced 105 mm Royal Ordnance L7 gun, while later variants feature a licensed Rheinmetall 120 mm L/44.

<span class="mw-page-title-main">Newton's laws of motion</span> Laws in physics about force and motion

Newton's laws of motion are three basic laws of classical mechanics that describe the relationship between the motion of an object and the forces acting on it. These laws can be paraphrased as follows:

  1. A body remains at rest, or in motion at a constant speed in a straight line, unless acted upon by a force.
  2. When a body is acted upon by a force, the time rate of change of its momentum equals the force.
  3. If two bodies exert forces on each other, these forces have the same magnitude but opposite directions.
<span class="mw-page-title-main">ANSI escape code</span> Method used for display options on video text terminals

ANSI escape sequences are a standard for in-band signaling to control cursor location, color, font styling, and other options on video text terminals and terminal emulators. Certain sequences of bytes, most starting with an ASCII escape character and a bracket character, are embedded into text. The terminal interprets these sequences as commands, rather than text to display verbatim.

<span class="mw-page-title-main">Appalachian Mountains</span> Mountain range in the eastern United States and Canada

The Appalachian Mountains, often called the Appalachians,, are a system of mountains in eastern to northeastern North America. The Appalachians first formed roughly 480 million years ago during the Ordovician Period. They once reached elevations similar to those of the Alps and the Rocky Mountains before experiencing natural erosion. The Appalachian chain is a barrier to east–west travel, as it forms a series of alternating ridgelines and valleys oriented in opposition to most highways and railroads running east–west.

<span class="mw-page-title-main">M2 Browning</span> Type of heavy machine gun

The M2 machine gun or Browning .50 caliber machine gun is a heavy machine gun that was designed towards the end of World War I by John Browning. Its design is similar to Browning's earlier M1919 Browning machine gun, which was chambered for the .30-06 cartridge. The M2 uses Browning's larger and more powerful .50 BMG cartridge. The design has had many designations; the official U.S. military designation for the current infantry type is Browning Machine Gun, Cal. .50, M2, HB, Flexible. It is effective against infantry, unarmored or lightly armored vehicles and boats, light fortifications, and low-flying aircraft.

<span class="mw-page-title-main">M4 carbine</span> Assault rifle

The M4 carbine is a 5.56×45mm NATO, gas-operated, magazine-fed carbine developed in the United States during the 1980s. It is a shortened version of the M16A2 assault rifle.

<span class="mw-page-title-main">Burj Khalifa</span> Skyscraper in Dubai, United Arab Emirates

The Burj Khalifa, known as the Burj Dubai prior to its inauguration in 2010, is a skyscraper in Dubai, United Arab Emirates. It is known for being the world’s tallest building. With a total height of 829.8 m and a roof height of 828 m (2,717 ft), the Burj Khalifa has been the tallest structure and building in the world since its topping out in 2009, supplanting Taipei 101, the previous holder of that status.

<span class="mw-page-title-main">2004 Indian Ocean earthquake and tsunami</span> Earthquake and subsequent tsunami in the Indian Ocean

An earthquake and a tsunami, known as the Boxing Day Tsunami and, by the scientific community, the Sumatra–Andaman earthquake, occurred at 07:58:53 local time (UTC+7) on 26 December 2004, with an epicentre off the west coast of northern Sumatra, Indonesia. It was an undersea megathrust earthquake that registered a magnitude of 9.1–9.3 Mw, reaching a Mercalli intensity up to IX in certain areas. The earthquake was caused by a rupture along the fault between the Burma Plate and the Indian Plate.

<span class="mw-page-title-main">R.E.M.</span> American alternative rock band

R.E.M. was an American rock band from Athens, Georgia, formed in 1980 by drummer Bill Berry, guitarist Peter Buck, bassist Mike Mills, and lead vocalist Michael Stipe, who were students at the University of Georgia. One of the first alternative rock bands, R.E.M. was noted for Buck's ringing, arpeggiated guitar style; Stipe's distinctive vocal quality, unique stage presence, and obscure lyrics; Mills's melodic bass lines and backing vocals; and Berry's tight, economical drumming style. In the early 1990s, other alternative rock acts such as Nirvana and Pavement viewed R.E.M. as a pioneer of the genre. After Berry left the band in 1997, the band continued its career in the 2000s with mixed critical and commercial success. The band broke up amicably in 2011 with members devoting time to solo projects after having sold more than 85 million albums worldwide and becoming one of the world's best-selling music acts.

<span class="mw-page-title-main">Plant</span> Kingdom of mainly multicellular, predominantly photosynthetic eukaryotes

Plants are predominantly photosynthetic eukaryotes of the kingdom Plantae. Historically, the plant kingdom encompassed all living things that were not animals, and included algae and fungi; however, all current definitions of Plantae exclude the fungi and some algae, as well as the prokaryotes. By one definition, plants form the clade Viridiplantae which is sister of the Glaucophyta, and consists of the green algae and Embryophyta. The latter includes the flowering plants, conifers and other gymnosperms, ferns and their allies, hornworts, liverworts, and mosses.

<span class="mw-page-title-main">PD-137889</span> Chemical compound

PD-137889 (N-methylhexahydrofluorenamine) is a chemical compound that is active as an NMDA receptor antagonist in the central nervous system at roughly 30 times the potency of the "flagship" of its class, ketamine, and substitutes for phencyclidine in animal studies. Ki [3H]TCP binding = 27 nM versus ketamine's Ki = 860 nM.

References

  1. Schweri, M. M.; De Costa, B. R.; Rice, K. C. (1998). "Fourphit, an acylating phencyclidine derivative, attenuates cocaine-induced hyperactivity in rats". Pharmacology Biochemistry and Behavior. 60 (3): 615–23. doi:10.1016/s0091-3057(98)00040-9. PMID   9678644. S2CID   1151532.