Names | |
---|---|
IUPAC name dicopper 2-acetyloxybenzoate | |
Other names tetrakis-μ-acetylsalicylato-dicopper(II), copper(II) aspirinate, cupric acetylsalicylate, cupric aspirinate, cupric aspirin complex | |
Identifiers | |
3D model (JSmol) | |
ChemSpider | |
ECHA InfoCard | 100.041.622 |
PubChem CID | |
CompTox Dashboard (EPA) | |
| |
| |
Properties | |
C36H28Cu2O16 | |
Molar mass | 843.69g/mol |
Appearance | Bright blue crystalline solid. |
Melting point | 248 to 255 °C (478 to 491 °F; 521 to 528 K) (decomposes) |
Pharmacology | |
Pharmacokinetics: | |
8.67 h (Human)[Ref#2] | |
Hazards | |
NIOSH (US health exposure limits): | |
PEL (Permissible) | TWA 1 mg/m3 (as Cu) [1] |
REL (Recommended) | TWA 1 mg/m3 (as Cu) [1] |
IDLH (Immediate danger) | TWA 100 mg/m3 (as Cu) [1] |
Related compounds | |
Other cations | Zinc aspirinate, Aluminium aspirinate |
Related compounds | Aspirin |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Copper(II) aspirinate is an aspirin chelate of copper(II) cations (Cu2+). It is used to treat rheumatoid arthritis.
Copper aspirinate can be prepared by several methods. In one route of preparation, an excess of acetylsalicylic acid is dissolved in aqueous sodium carbonate. Sodium hydroxide is not suitable for this purpose, because it will hydrolyse acetylsalicylic acid (ASA) into salicylic acid and sodium acetate.
The resulting solution is then filtered to remove any undissolved acetylsalicylic acid and is mixed with a solution containing Cu2+ cations (copper(II) sulfate is suitable), precipitating bright blue crystals of copper aspirinate immediately. The crystals can then be filtered from solution, washed, and dried. An excess of acetylsalicylic acid is used in the first step, because it eliminates the possibility of unreacted carbonate anions precipitating the copper in this step.
Copper aspirinate has been proven effective as a treatment for rheumatoid arthritis. [2] A pharmacokinetic study in healthy human volunteers supports its enhanced efficacy as compared with aspirin. [3] The studies on animal models suggest that copper aspirinate is very promising in treating against thrombotic diseases and it has all the prospects of success in becoming an antithrombotic drug that prevents and treats thrombotic diseases in humans. [4]
The use of copper aspirinate as a pigment in PVC and polystyrene has also been investigated. [5]
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has generic name (help)CS1 maint: multiple names: authors list (link)In chemistry, a salt is a chemical compound consisting of an ionic assembly of positively charged cations and negatively charged anions, which results in a compound with no net electric charge. A common example is table salt, with positively charged sodium ions and negatively charged chloride ions.
Sodium hydroxide, also known as lye and caustic soda, is an inorganic compound with the formula NaOH. It is a white solid ionic compound consisting of sodium cations Na+ and hydroxide anions OH−.
Sodium bicarbonate (IUPAC name: sodium hydrogencarbonate), commonly known as baking soda or bicarbonate of soda, is a chemical compound with the formula NaHCO3. It is a salt composed of a sodium cation (Na+) and a bicarbonate anion (HCO3−). Sodium bicarbonate is a white solid that is crystalline, but often appears as a fine powder. It has a slightly salty, alkaline taste resembling that of washing soda (sodium carbonate). The natural mineral form is nahcolite. It is a component of the mineral natron and is found dissolved in many mineral springs.
Benedict's reagent is a chemical reagent and complex mixture of sodium carbonate, sodium citrate, and copper(II) sulfate pentahydrate. It is often used in place of Fehling's solution to detect the presence of reducing sugars. The presence of other reducing substances also gives a positive result. Such tests that use this reagent are called the Benedict's tests. A positive test with Benedict's reagent is shown by a color change from clear blue to brick-red with a precipitate.
Basic copper carbonate is a chemical compound, more properly called copper(II) carbonate hydroxide. It is an ionic compound consisting of the ions copper(II) Cu2+
, carbonate CO2−
3, and hydroxide OH−
.
The common-ion effect refers to the decrease in solubility of an ionic precipitate by the addition to the solution of a soluble compound with an ion in common with the precipitate. This behaviour is a consequence of Le Chatelier's principle for the equilibrium reaction of the ionic association/dissociation. The effect is commonly seen as an effect on the solubility of salts and other weak electrolytes. Adding an additional amount of one of the ions of the salt generally leads to increased precipitation of the salt, which reduces the concentration of both ions of the salt until the solubility equilibrium is reached. The effect is based on the fact that both the original salt and the other added chemical have one ion in common with each other.
Copper(II) oxide or cupric oxide is an inorganic compound with the formula CuO. A black solid, it is one of the two stable oxides of copper, the other being Cu2O or copper(I) oxide (cuprous oxide). As a mineral, it is known as tenorite. It is a product of copper mining and the precursor to many other copper-containing products and chemical compounds.
Classical qualitative inorganic analysis is a method of analytical chemistry which seeks to find the elemental composition of inorganic compounds. It is mainly focused on detecting ions in an aqueous solution, therefore materials in other forms may need to be brought to this state before using standard methods. The solution is then treated with various reagents to test for reactions characteristic of certain ions, which may cause color change, precipitation and other visible changes.
Manganese(II) chloride is the dichloride salt of manganese, MnCl2. This inorganic chemical exists in the anhydrous form, as well as the dihydrate (MnCl2·2H2O) and tetrahydrate (MnCl2·4H2O), with the tetrahydrate being the most common form. Like many Mn(II) species, these salts are pink, with the paleness of the color being characteristic of transition metal complexes with high spin d5 configurations.
Copper(II) chloride is the chemical compound with the chemical formula CuCl2. The anhydrous form is yellowish brown but slowly absorbs moisture to form a blue-green dihydrate.
Copper(II) hydroxide is the hydroxide of copper with the chemical formula of Cu(OH)2. It is a pale greenish blue or bluish green solid. Some forms of copper(II) hydroxide are sold as "stabilized" copper(II) hydroxide, although they likely consist of a mixture of copper(II) carbonate and hydroxide. Cupric hydroxide is a strong base, although its low solubility in water makes this hard to observe directly.
Copper(I) cyanide is an inorganic compound with the formula CuCN. This off-white solid occurs in two polymorphs; impure samples can be green due to the presence of Cu(II) impurities. The compound is useful as a catalyst, in electroplating copper, and as a reagent in the preparation of nitriles.
Sodium dichloroisocyanurate is a chemical compound widely used as a cleansing agent and disinfectant. It is a colorless, water-soluble solid, produced as a result of reaction of cyanuric acid with chlorine. The dihydrate is also known as is the potassium salt.
Aurothioglucose, also known as gold thioglucose, is a chemical compound with the formula AuSC6H11O5. This derivative of the sugar glucose was formerly used to treat rheumatoid arthritis.
Copper benzoate is the chemical compound with the formula Cu(C6H5CO2)2. This coordination complex is derived from the cupric ion and the conjugate base of benzoic acid. Because copper emits blue in a flame, this salt has found some use as a source of blue light in fireworks.
Sodium sesquicarbonate (systematic name: trisodium hydrogendicarbonate) Na3H(CO3)2 is a double salt of sodium bicarbonate and sodium carbonate (NaHCO3 · Na2CO3), and has a needle-like crystal structure. However, the term is also applied to an equimolar mixture of those two salts, with whatever water of hydration the sodium carbonate includes, supplied as a powder.
Cobalt extraction refers to the techniques used to extract cobalt from its ores and other compound ores. Several methods exist for the separation of cobalt from copper and nickel. They depend on the concentration of cobalt and the exact composition of the ore used.
Dicopper chloride trihydroxide is the chemical compound with the formula Cu2(OH)3Cl. It is often referred to as tribasic copper chloride (TBCC), copper trihydroxyl chloride or copper hydroxychloride. It is a greenish crystalline solid encountered in mineral deposits, metal corrosion products, industrial products, art and archeological objects, and some living systems. It was originally manufactured on an industrial scale as a precipitated material used as either a chemical intermediate or a fungicide. Since 1994, a purified, crystallized product has been produced at the scale of thousands of tons per year, and used extensively as a nutritional supplement for animals.
Chalconatronite is a carbonate mineral and rare secondary copper mineral that contains copper, sodium, carbon, oxygen, and hydrogen, its chemical formula is Na2Cu(CO3)2•3(H2O). Chalconatronite is partially soluble in water, and only decomposes, although chalconatronite is soluble while cold, in dilute acids. The name comes from the mineral's compounds, copper ("chalcos" in Greek) and natron, naturally forming sodium carbonate. The mineral is thought to be formed by water carrying alkali carbonates (possibly from soil) reacting with bronze. Similar minerals include malachite, azurite, and other copper carbonates. Chalconatronite has also been found and recorded in Australia, Germany, and Colorado.