AGH-107

Last updated
AGH-107
AGH-107.png
Identifiers
  • 3-(3-ethylimidazol-4-yl)-5-iodo-1H-indole
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C13H12IN3
Molar mass 337.164 g·mol−1
3D model (JSmol)
  • CCn1cncc1-c1c[nH]c2ccc(I)cc12
  • InChI=1S/C13H12IN3/c1-2-17-8-15-7-13(17)11-6-16-12-4-3-9(14)5-10(11)12/h3-8,16H,2H2,1H3
  • Key:JLCILCCDUVFIRF-UHFFFAOYSA-N

AGH-107 is a potent, selective, water-soluble and brain penetrant full agonist at the 5-HT7 serotonin receptor of the imidazolylindole family. [1] AGH-107 is one of the few examples of low-basicity aminergic receptor agonists, which may underlie its high selectivity over the related central nervous system targets. AGH-107 was found to reverse the impairment in novel object recognition caused by MK-801 in mice. The relatively short half-life in rodents inhibited its use as a molecular probe.

See also

References

  1. Hogendorf AS, Hogendorf A, Kurczab R, Satała G, Lenda T, Walczak M, et al. (May 2017). "7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol". Scientific Reports. 7 (1): 1444. doi:10.1038/s41598-017-00822-4. PMC   5431432 . PMID   28473721.