6-Hydroxymelatonin

Last updated
6-Hydroxymelatonin
6-Hydroxymelatonin structure.svg
Names
Preferred IUPAC name
N-[2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide
Other names
6-Oxymelatonin
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.164.426 OOjs UI icon edit-ltr-progressive.svg
KEGG
PubChem CID
UNII
  • InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
    Key: OMYMRCXOJJZYKE-UHFFFAOYSA-N
  • InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
    Key: OMYMRCXOJJZYKE-UHFFFAOYAK
  • CC(=O)NCCC1=CNC2=CC(=C(C=C21)OC)O
Properties
C13H16N2O3
Molar mass 248.282 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

6-Hydroxymelatonin (6-OHM) is a naturally occurring, endogenous, major active metabolite of melatonin. [1] Similar to melatonin, 6-OHM is a full agonist of the MT1 and MT2 receptors. [2] [3] It is also an antioxidant and neuroprotective, and is even more potent in this regard relative to melatonin. [4] [5]

See also

Related Research Articles

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TIK-301

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References

  1. Hardeland R (2010). "Melatonin metabolism in the central nervous system". Curr Neuropharmacol. 8 (3): 168–81. doi:10.2174/157015910792246164. PMC   3001211 . PMID   21358968.
  2. Dubocovich ML (1988). "Pharmacology and function of melatonin receptors". FASEB J. 2 (12): 2765–73. doi:10.1096/fasebj.2.12.2842214. PMID   2842214. S2CID   45788574.
  3. Browning, Christopher; Beresford, Isabel; Fraser, Neil; Giles, Heather (2000). "Pharmacological characterization of human recombinant melatonin mt1and MT2receptors". British Journal of Pharmacology. 129 (5): 877–886. doi:10.1038/sj.bjp.0703130. ISSN   0007-1188. PMC   1571913 . PMID   10696085.
  4. Maharaj DS, Glass BD, Daya S (2007). "Melatonin: new places in therapy". Biosci. Rep. 27 (6): 299–320. doi:10.1007/s10540-007-9052-1. PMID   17828452. S2CID   32437175.
  5. Álvarez-Diduk R, Galano A, Tan DX, Reiter RJ (2015). "N-Acetylserotonin and 6-Hydroxymelatonin against Oxidative Stress: Implications for the Overall Protection Exerted by Melatonin". J Phys Chem B. 119 (27): 8535–43. doi: 10.1021/acs.jpcb.5b04920 . PMID   26079042.