5-Fluoro-DET

Last updated

5-Fluoro-DET
5-Fluoro-DET.svg
Clinical data
Other names
  • 5-F-DET
  • 5-Fluoro-N,N-diethyltryptamine
Identifiers
  • N,N-diethyl-2-(5-fluoro-1H-indol-3-yl)ethanamine
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
Formula C14H19FN2
Molar mass 234.318 g·mol−1
3D model (JSmol)
  • CCN(CC)CCC1=CNC2=C1C=C(C=C2)F
  • InChI=1S/C14H19FN2/c1-3-17(4-2)8-7-11-10-16-14-6-5-12(15)9-13(11)14/h5-6,9-10,16H,3-4,7-8H2,1-2H3
  • Key:LBJIPBJDJFZKIQ-UHFFFAOYSA-N

5-Fluoro-DET, or 5-F-DET, also known as 5-fluoro-N,N-diethyltryptamine, is a tryptamine derivative related to drugs such as diethyltryptamine (DET) and 5-MeO-DET. [1] [2] It is known to act as an inhibitor of the enzyme myeloperoxidase, [3] and is also thought to be an agonist at the serotonin 5-HT2A receptor. [4]

Contents

See also

References

  1. ↑ Pelchowicz Z, Kaluszyner A, Bentov M (1961). "1067. N-alkylated 5-fluorotryptamines". Journal of the Chemical Society (Resumed): 5418–5421. doi:10.1039/JR9610005418.
  2. ↑ Kalir A, Szara S (May 1966). "Synthesis and pharmacological activity of alkylated tryptamines". Journal of Medicinal Chemistry. 9 (3): 341–4. doi:10.1021/jm00321a017. PMID   5960901.
  3. ↑ Soubhye J, Prévost M, Van Antwerpen P, Zouaoui Boudjeltia K, Rousseau A, Furtmüller PG, Obinger C, Vanhaeverbeek M, Ducobu J, Néve J, Gelbcke M, Dufrasne FO (December 2010). "Structure-based design, synthesis, and pharmacological evaluation of 3-(aminoalkyl)-5-fluoroindoles as myeloperoxidase inhibitors" (PDF). Journal of Medicinal Chemistry. 53 (24): 8747–59. doi:10.1021/jm1009988. PMID   21090682. S2CID   207225972.
  4. ↑ WO 2021/168082,Kruegel AC, Sporn J,"Specific Tryptamines for use in the Treatment of Mood Disorders.",published 26 August 2021, assigned to Gilgamesh Pharmaceuticals, Inc..
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