Tetrahydrocarbazolamine

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Tetrahydrocarbazolamines, or tetrahydrocarbazolylamines, also known as aminotetrahydrocarbazoles, are a group of cyclized tryptamines in which the indole ring has been cyclized into a tricyclic tetrahydrocarbazole ring system. They include the antipsychotics ciclindole and flucindole, the triptans frovatriptan and LY-344864, and the antiplatelet drug ramatroban. Tetrahydrocarbazolamines are known to act as serotonin receptor modulators, as well as modulators of other receptors such as dopamine and adrenergic receptors. [1] [2]

See also

References

  1. ↑ Wood PL, McQuade PS (1984). "Ciclindole and flucindole: novel tetrahydrocarbazolamine neuroleptics". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 8 (4–6): 773–777. doi:10.1016/0278-5846(84)90057-5. PMID   6152347. S2CID   39252411.
  2. ↑ Vries, Peter De; Villalón, Carlos M; Saxena, Pramod R (1999). "Pharmacology of triptans". Emerging Drugs. 4 (1): 107–125. doi:10.1517/14728214.4.1.107. ISSN   1361-9195 . Retrieved 29 July 2025.



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