Tetrahydropyridinylpyrrolopyridine

Tetrahydropyridinylpyrrolopyridines are a group of pyrrolopyridine and tetrahydropyridine derivatives related to the tryptamines. They are not tryptamines themselves, as they feature a pyrrolopyridine instead of indole ring system. The compounds include (R)-69, (R)-70, and CP-94253. They are known to act as serotonin receptor agonists, including of the serotonin 5-HT₁ and/or 5-HT₂ receptors. ^{[1] [2]} Some tetrahydropyridinylpyrrolopyridines, such as (R)-69 and (R)-70, were discovered by Bryan L. Roth and colleagues via ultra-large-scale docking. ^[2]

Chemical structures of selected tetrahydropyridinylpyrrolopyridines

• 
  (R)-69
• 
  (R)-70
• 
  CP-94253

See also

• Cyclized tryptamine
• Indazolethylamine
• Indolizinylethylamine
• List of miscellaneous 5-HT_2A receptor agonists
• Ultra-large-scale docking
• WAY-208466

References

1. Koe, B. Kenneth; Nielsen, Jann A.; Macor, John E.; Heym, James (1992). "Biochemical and behavioral studies of the 5-HT 1B receptor agonist, CP-94,253". Drug Development Research. 26 (3): 241–250. doi:10.1002/ddr.430260305. ISSN   0272-4391 . Retrieved 30 July 2025.
2. Kaplan AL, Confair DN, Kim K, Barros-Álvarez X, Rodriguiz RM, Yang Y, Kweon OS, Che T, McCorvy JD, Kamber DN, Phelan JP, Martins LC, Pogorelov VM, DiBerto JF, Slocum ST, Huang XP, Kumar JM, Robertson MJ, Panova O, Seven AB, Wetsel AQ, Wetsel WC, Irwin JJ, Skiniotis G, Shoichet BK, Roth BL, Ellman JA (October 2022). "Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity". Nature. 610 (7932): 582–591. doi:10.1038/s41586-022-05258-z. PMC   9996387 . PMID   36171289.