AGH-192

Last updated

AGH-192
AGH-192 structure.png
Identifiers
  • 3-(3-ethylimidazol-4-yl)-4-fluoro-5-iodo-1H-indole
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C13H11FIN3
Molar mass 355.155 g·mol−1
3D model (JSmol)
  • CCN1C=NC=C1C2=CNC3=C2C(=C(C=C3)I)F
  • InChI=1S/C13H11FIN3/c1-2-18-7-16-6-11(18)8-5-17-10-4-3-9(15)13(14)12(8)10/h3-7,17H,2H2,1H3
  • Key:KBQLQDPQEMFGCB-UHFFFAOYSA-N

AGH-192 is a potent and selective, water soluble, orally bioavailable and brain penetrant full agonist at the 5-HT7 serotonin receptor of the imidazolylindole family, derived from the older drug AGH-107. In animal tests it showed activity indicative of potential application in the treatment of neuropathic pain. [1]

See also

References

  1. Hogendorf AS, Hogendorf A, Popiolek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Kurczab R, Satała G, Lenda T, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Wierońska JM, Woźniak M, Cieślik P, Bugno R, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ (2019). "Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers". European Journal of Medicinal Chemistry. 170: 261–275. doi:10.1016/j.ejmech.2019.03.017. PMID   30904783. S2CID   85498356.