4-AcO-MALT

Last updated

4-AcO-MALT
4-AcO-MALT structure.png
Clinical data
Other names4-Acetoxy-MALT; 4-Acetoxy-N-methyl-N-allyltryptamine
Drug class Serotonin receptor modulator; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C16H20N2O2
Molar mass 272.348 g·mol−1
3D model (JSmol)
  • C=CCN(CCc1c[nH]c2c1c(ccc2)OC(=O)C)C
  • InChI=InChI=1S/C16H20N2O2/c1-4-9-18(3)10-8-13-11-17-14-6-5-7-15(16(13)14)20-12(2)19/h4-7,11,17H,1,8-10H2,2-3H3
  • Key:PGBFYUDKPCYIEB-UHFFFAOYSA-N

4-AcO-MALT, or 4-acetoxy-MALT, also known as 4-acetoxy-N-methyl-N-allyltryptamine, is a psychedelic drug of the tryptamine family. [1] [2] [3] It is the acetate ester of 4-HO-MALT. [1] [2] [3]

Contents

The drug is assumed to act as a prodrug of the serotonergic psychedelic 4-HO-MALT. [1] 4-HO-MALT is a serotonin receptor modulator, including acting as an agonist of the serotonin 5-HT2 receptors. [2] The receptor interactions of 4-AcO-MALT have also been studied. [2] [3]

4-AcO-MALT was first described in the scientific literature by at least 2021. [1] It was encountered as a novel designer drug. [4] [5]

See also

References

  1. 1 2 3 4 Pham DN, Chadeayne AR, Golen JA, Manke DR (1 February 2021). "Psilacetin derivatives: fumarate salts of the methyl–ethyl, methyl–allyl and diallyl variants of the psilocin prodrug". Acta Crystallographica Section E. 77 (Pt 2): 101–106. Bibcode:2021AcCrE..77..101P. doi: 10.1107/S2056989021000116 . ISSN   2056-9890. PMC   7869532 . PMID   33614134.
  2. 1 2 3 4 Glatfelter GC, Naeem M, Pham DN, Golen JA, Chadeayne AR, Manke DR, et al. (April 2023). "Receptor Binding Profiles for Tryptamine Psychedelics and Effects of 4-Propionoxy-N,N-dimethyltryptamine in Mice". ACS Pharmacology & Translational Science. 6 (4): 567–577. doi:10.1021/acsptsci.2c00222. PMC   10111620 . PMID   37082754.
  3. 1 2 3 Jain MK, Gumpper RH, Slocum ST, Schmitz GP, Madsen JS, Tummino TA, et al. (July 2025). "The polypharmacology of psychedelics reveals multiple targets for potential therapeutics" (PDF). Neuron. doi:10.1016/j.neuron.2025.06.012. PMID   40683247.
  4. Miller JJ, Yazdanpanah M, Colantonio DA, Beriault DR, Delaney SR (2024). "New Psychoactive Substances: A Canadian perspective on emerging trends and challenges for the clinical laboratory". Clinical Biochemistry. 133–134 110810: 110810. doi:10.1016/j.clinbiochem.2024.110810. PMID   39181179.{{cite journal}}: CS1 maint: article number as page number (link)
  5. Axelsson MA, Lövgren H, Kronstrand R, Green H, Bergström MA (2022). "Retrospective identification of new psychoactive substances in patient samples submitted for clinical drug analysis". Basic & Clinical Pharmacology & Toxicology. 131 (5): 420–434. doi: 10.1111/bcpt.13786 . ISSN   1742-7835. PMID   36028947.