1F-LSD

Last updated

1F-LSD
1F-LSD.svg
Clinical data
Other names1-Formyl-LSD; 1-Formyl-N,N-diethyllysergamide; N,N-Diethyl-1-formyl-6-methyl-9,10-didehydroergoline-8β-carboxamide
Routes of
administration 		Oral; Sublingual
Drug class Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
  • N,N-Diethyl-1-formyl-6-methyl-9,10-didehydroergoline-8β-carboxamide
Chemical and physical data
Formula C21H25N3O2
Molar mass 351.450 g·mol−1
3D model (JSmol)
  • CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C=O)CC
  • InChI=1S/C21H25N3O2/c1-4-23(5-2)21(26)15-9-17-16-7-6-8-18-20(16)14(12-24(18)13-25)10-19(17)22(3)11-15/h6-9,12-13,15,19H,4-5,10-11H2,1-3H3/t15-,19-/m1/s1
  • Key:SSEPNHFOVYUBHO-DNVCBOLYSA-N

1F-LSD, or 1-formyl-LSD, also known as 1-formyl-N,N-diethyllysergamide, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). [1] [2] It is the 1-formyl derivative of LSD. [1] [2] [3]

Contents

The drug is assumed to act as a prodrug of LSD. [1] It produces psychedelic effects in humans similarly to LSD. [2] Effective doses have been reported to be 100 to 150 μg orally or sublingually. [2] Very little is known about the pharmacology and properties of 1F-LSD. [1]

1F-LSD was first described in the scientific literature by 2021. [2] It first emerged as a novel designer drug online in January 2019. [1] [2]

Another compound, 1‐(furan‐2‐carbonyl)‐LSD (SYN-L-005), has also been referred to as "1F-LSD". [3]

See also

References

  1. 1 2 3 4 5 "1F-LSD". АИПСИН (in Russian). Retrieved 26 July 2025.
  2. 1 2 3 4 5 6 Catalani V, Arillotta D, Corkery JM, Guirguis A, Vento A, Schifano F (9 February 2021). "Identifying New/Emerging Psychoactive Substances at the Time of COVID-19; A Web-Based Approach". Frontiers in Psychiatry. 11. doi: 10.3389/fpsyt.2020.632405 . ISSN   1664-0640. PMC   7900492 . PMID   33633599.
  3. 1 2 Brandt SD, Kavanagh PV, Gare S, Elliott SP, Stratford A, Halberstadt AL (3 December 2024). "Analytical and Pharmacological Characterization of 1‐(Furan‐2‐Carbonyl)‐LSD (1F‐LSD) and Comparison With 1‐(Thiophene‐2‐Carbonyl)‐LSD (1T‐LSD)". Drug Testing and Analysis. doi: 10.1002/dta.3829 . ISSN   1942-7603. PMC   12319525 . PMID   39624022.



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