HOT-x

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HOT-2 (N-hydroxy-2C-T-2), a psychedelic drug of the HOT-x group. HOT-2.svg
HOT-2 (N-hydroxy-2C-T-2), a psychedelic drug of the HOT-x group.

HOT-x, also known as 4-alkylthio-2,5-dimethoxy-N-hydroxyphenethylamines or hydroxylated 2C-T derivatives, are a group of psychedelic drugs of the phenethylamine and 2C families. [1] [2] They have a hydroxy group (HO) at the amine as well as methoxy groups at the 2 and 5 positions and an alkyl thio (T) group at the 4 position of the phenyl ring. [1] [2] The HOT-x drugs are the N-hydroxyl analogues of the corresponding 2C-T-x drugs. [1] [2]

Contents

The HOT-x drugs were synthesized and tested by Alexander Shulgin and were reported by him in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). [1] [2]

Use and effects

All three of the HOT-x drugs produce psychedelic effects according to Shulgin. [1] [2] The HOT-x drugs are said to be very similar to their 2C-T counterparts in terms of properties and effects and may act as prodrugs to these compounds. [2]

Interactions

Society and culture

Canada

The HOT-x drugs are controlled substances in Canada under phenethylamine blanket-ban language. [5]

See also

References

  1. 1 2 3 4 5 6 Shulgin, A.; Manning, T.; Daley, P.F. (2011). The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds . Vol. 1. Berkeley: Transform Press. ISBN   978-0-9630096-3-0.
  2. 1 2 3 4 5 6 7 8 Alexander T. Shulgin; Ann Shulgin (1991). PiHKAL: A Chemical Love Story (1st ed.). Berkeley, CA: Transform Press. ISBN   978-0-9630096-0-9. OCLC   25627628.
  3. ↑ Shulgin AT (2003). "Basic Pharmacology and Effects". In Laing RR (ed.). Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137. ISBN   978-0-12-433951-4. Archived from the original on 13 July 2025.
  4. ↑ Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. pp. 792–792. ISBN   978-3-03788-700-4. OCLC   858805226. Archived from the original on 21 August 2025.
  5. ↑ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
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