4-AcO-MPT

Last updated

4-AcO-MPT
Clinical data
Other names4-Acetoxy-MPT; 4-Acetoxy-N-methyl-N-propyltryptamine
Routes of
administration 		Oral
Drug class Non-selective serotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
  • [3-[2-[methyl(propyl)amino]ethyl]-1H-indol-4-yl] acetate
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C16H22N2O2
Molar mass 274.364 g·mol−1
3D model (JSmol)
  • CCCN(C)CCC1=CNC2=C1C(=CC=C2)OC(=O)C
  • InChI=1S/C16H22N2O2/c1-4-9-18(3)10-8-13-11-17-14-6-5-7-15(16(13)14)20-12(2)19/h5-7,11,17H,4,8-10H2,1-3H3
  • Key:CECCEKYTLKWWJJ-UHFFFAOYSA-N

4-AcO-MPT, also known as 4-acetoxy-N-methyl-N-propyltryptamine, is a psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to 4-AcO-DMT (psilacetin). [1] [2] [3] [4] [5] [5] It is thought to act as a prodrug of 4-HO-MPT and hence is believed to act as a non-selective serotonin receptor agonist including of the serotonin 5-HT2A receptor. [3] [4] The drug produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, [4] and was first encountered as a novel designer drug in 2018. [1] 4-AcO-MPT was first described in the scientific literature by at least 2017. [2]

Contents

Interactions

See also

References

  1. 1 2 "4-AcO-MPT". АИПСИН (in Russian). Retrieved 11 October 2025.
  2. 1 2 Chapman S (31 December 2017). PeakAL: Protons I Have Known and Loved, Too — Another Fifty Shades of Grey-Market Spectra (PDF) (Report). doi: 10.16889/isomerdesign-5 . Retrieved 11 October 2025.
  3. 1 2 Berardinelli D, Montanari E, Malaca S, Zaami S, Busardò FP, Huestis MA, et al. (2022). "4-Hydroxy-N,N-methylpropyltryptamine (4-OH-MPT) in vitro human metabolism". Toxicologie Analytique et Clinique. 34 (3): S96. Bibcode:2022ToxAC..34Q..96B. doi: 10.1016/j.toxac.2022.06.147 .
  4. 1 2 3 Klein AK, Chatha M, Laskowski LJ, Anderson EI, Brandt SD, Chapman SJ, et al. (April 2021). "Investigation of the Structure-Activity Relationships of Psilocybin Analogues". ACS Pharmacology & Translational Science. 4 (2): 533–542. doi:10.1021/acsptsci.0c00176. PMC   8033608 . PMID   33860183.
  5. 1 2 Glatfelter GC, Naeem M, Pham DN, Golen JA, Chadeayne AR, Manke DR, et al. (April 2023). "Receptor Binding Profiles for Tryptamine Psychedelics and Effects of 4-Propionoxy-N,N-dimethyltryptamine in Mice". ACS Pharmacology & Translational Science. 6 (4): 567–577. doi:10.1021/acsptsci.2c00222. PMC   10111620 . PMID   37082754.
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