IHCH-8134

Last updated

IHCH-8134
IHCH-8134.svg
Identifiers
  • (6bR,10aS)-8-(3-(2-methoxyphenyl)propyl)-1,2,6b,7,8,9,10,10a-octahydro-[1,4]oxazino[2,3,4-hi]pyrido[4,3-b]indole
PubChem CID
Chemical and physical data
Formula C23H28N2O2
Molar mass 364.489 g·mol−1
3D model (JSmol)
  • [H][C@@]12[C@@](CCN(CCCC3=CC=CC=C3OC)C2)([H])N4CCOC5=C4C1=CC=C5
  • InChI=InChI=1S/C23H28N2O2/c1-26-21-9-3-2-6-17(21)7-5-12-24-13-11-20-19(16-24)18-8-4-10-22-23(18)25(20)14-15-27-22/h2-4,6,8-10,19-20H,5,7,11-16H2,1H3/t19-,20-/m0/s1
  • Key:XIZOEKLHAJIDMD-PMACEKPBSA-N

IHCH-8134 is a drug of the oxazinopyridoindole family which acts as an agonist at the 5-HT2A serotonin receptor. It was derived by structural simplification of the 5-HT2A antagonist atypical antipsychotic drug lumateperone along with several related compounds such as IHCH-7079, which was found to be a non-hallucinogenic biased 5-HT2A agonist that was active in antidepressant assays but did not produce psychedelic-like responding in mice. [1] [2] [3]

See also

References

  1. US 6552017,Robichaud AJ, Lee T, Deng W, Mitchell IS, Yang MG, Haydar S, Chen W, Mc Clung CD, Calvello EJ, Zawrotny DM,"Substituted heterocycle fused gamma-carbolines.",issued 22 April 2003, assigned to Bristol Myers Squibb Pharma Co.
  2. US 9315504,Tomesch JC, Li P, Yao W, Zhang Q, Beard JD, Thompson AS, Cheng H, Wennogle LP,"Preparation of 4-((6BR,10AS)-3-methyl-2,3,6B,9,10, 10A-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo [1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone or a pharmaceutically acceptable salt thereof",issued 19 April 2016, assigned to Intra Cellular Therapies Inc.
  3. Cao D, Yu J, Wang H, Luo Z, Liu X, He L, et al. (January 2022). "Structure-based discovery of nonhallucinogenic psychedelic analogs". Science. 375 (6579). New York, N.Y.: 403–411. Bibcode:2022Sci...375..403C. doi:10.1126/science.abl8615. PMID   35084960. S2CID   246360313.