WAY-163909

Last updated
WAY-163909
WAY-163909.svg
Identifiers
  • (11R,15R)-7,10-diazatetracyclo[8.5.1.05,16.011,15]hexadeca-1,3,5(16)-triene
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C14H18N2
Molar mass 214.312 g·mol−1
3D model (JSmol)
  • C1C[C@H]2[C@@H](C1)N3CCNCC4=C3C2=CC=C4
  • InChI=1S/C14H18N2/c1-3-10-9-15-7-8-16-13-6-2-4-11(13)12(5-1)14(10)16/h1,3,5,11,13,15H,2,4,6-9H2/t11-,13-/m1/s1
  • Key:XOSKJKGKWRIMGV-DGCLKSJQSA-N

WAY-163,909 is a drug which acts as a potent and reasonably selective agonist for the serotonin 5-HT2C receptor. [1] [2] It has antipsychotic-like effects in animal models, [3] [4] and has been used to study the role of the 5-HT2C receptor subtype in the action of addictive drugs such as nicotine and methamphetamine. [5] [6]

See also

References

  1. ↑ Dunlop J, Sabb AL, Mazandarani H, Zhang J, Kalgaonker S, Shukhina E, et al. (May 2005). "WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity". The Journal of Pharmacology and Experimental Therapeutics. 313 (2): 862–9. doi:10.1124/jpet.104.075382. PMID   15705738. S2CID   767189.
  2. ↑ Dunlop J, Marquis KL, Lim HK, Leung L, Kao J, Cheesman C, Rosenzweig-Lipson S (2006). "Pharmacological profile of the 5-HT(2C) receptor agonist WAY-163909; therapeutic potential in multiple indications". CNS Drug Reviews. 12 (3–4): 167–77. doi:10.1111/j.1527-3458.2006.00167.x. PMC   6506193 . PMID   17227285.
  3. ↑ Marquis KL, Sabb AL, Logue SF, Brennan JA, Piesla MJ, Comery TA, et al. (January 2007). "WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A novel 5-hydroxytryptamine 2C receptor-selective agonist with preclinical antipsychotic-like activity". The Journal of Pharmacology and Experimental Therapeutics. 320 (1): 486–96. doi:10.1124/jpet.106.106989. PMID   17038512. S2CID   40512921.
  4. ↑ Grauer SM, Graf R, Navarra R, Sung A, Logue SF, Stack G, et al. (May 2009). "WAY-163909, a 5-HT2C agonist, enhances the preclinical potency of current antipsychotics". Psychopharmacology. 204 (1): 37–48. doi:10.1007/s00213-008-1433-z. PMID   19107466. S2CID   27417671.
  5. ↑ Zaniewska M, McCreary AC, Przegaliński E, Filip M (October 2007). "Effects of the serotonin 5-HT2A and 5-HT2C receptor ligands on the discriminative stimulus effects of nicotine in rats". European Journal of Pharmacology. 571 (2–3): 156–65. doi:10.1016/j.ejphar.2007.05.067. PMID   17617403.
  6. ↑ Odabas-Geldiay M, Shields H, Berro LF, Rice KC, Howell LL (January 2019). "Effects of acute treatments with the serotonin 2A antagonist M100907 alone or in combination with the serotonin 2C agonist WAY163909 on methamphetamine self-administration in rhesus monkeys". Drug and Alcohol Dependence. 194: 252–256. doi:10.1016/j.drugalcdep.2018.10.018. PMC   6312465 . PMID   30469095.
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