Drug discrimination

Not to be confused with Discrimination against drug addicts.

Drug discrimination (DD) is a technique in behavioral neuroscience used to evaluate the discriminative stimulus properties of psychoactive drugs. ^{[1] [2] [3] [4]} The discriminative stimulus properties of drugs are believed to reflect their subjective effects. ^[1] When partial or full stimulus generalization of a test drug to a training drug occurs, the test drug can be assumed to have effects that are subjectively similar to those of the training drug. ^[2] Drug discrimination tests are usually performed in animals, but have also been conducted in humans. ^{[5] [6]} Drug discrimination assays have been employed to assess whether drugs have stimulant-, hallucinogen- or entactogen-like effects, among many other types of drug effects. ^{[7] [8] [9]}

See also

• Head-twitch response

References

1. Porter JH, Prus AJ, Overton DA (2018). "Drug Discrimination: Historical Origins, Important Concepts, and Principles". The Behavioral Neuroscience of Drug Discrimination. Current Topics in Behavioral Neurosciences. Vol. 39. pp. 3–26. doi:10.1007/7854_2018_40. ISBN   978-3-319-98559-6. PMID   29637526.{{cite book}}: |journal= ignored (help)
2. Young, Richard (2009). "Drug Discrimination". Methods of Behavior Analysis in Neuroscience. Boca Raton (FL): CRC Press/Taylor & Francis. ISBN   978-1-4200-5234-3. PMID   21204332 . Retrieved 1 November 2024.
3. Colpaert FC (October 1999). "Drug discrimination in neurobiology". Pharmacol Biochem Behav. 64 (2): 337–345. doi:10.1016/s0091-3057(99)00047-7. PMID   10515310.
4. Stolerman, I.P. (1993). "Drug discrimination". Techniques in the Behavioral and Neural Sciences. Vol. 10. Elsevier. pp. 217–243. doi:10.1016/b978-0-444-81444-9.50014-6. ISBN   978-0-444-81444-9. ISSN   0921-0709.
5. Bolin BL, Alcorn JL, Reynolds AR, Lile JA, Rush CR (August 2016). "Human drug discrimination: A primer and methodological review". Exp Clin Psychopharmacol. 24 (4): 214–228. doi:10.1037/pha0000077. PMC   4965187 . PMID   27454673.
6. Bolin BL, Alcorn JL, Reynolds AR, Lile JA, Stoops WW, Rush CR (2018). "Human Drug Discrimination: Elucidating the Neuropharmacology of Commonly Abused Illicit Drugs". The Behavioral Neuroscience of Drug Discrimination. Current Topics in Behavioral Neurosciences. Vol. 39. pp. 261–295. doi:10.1007/7854_2016_10. ISBN   978-3-319-98559-6. PMC   5461212 . PMID   27272070.{{cite book}}: |journal= ignored (help)
7. Baker LE (2018). "Hallucinogens in Drug Discrimination". Behavioral Neurobiology of Psychedelic Drugs. Current Topics in Behavioral Neurosciences. Vol. 36. pp. 201–219. doi:10.1007/7854_2017_476. ISBN   978-3-662-55878-2. PMID   28484970.{{cite book}}: |journal= ignored (help)
8. Winter JC (April 2009). "Hallucinogens as discriminative stimuli in animals: LSD, phenethylamines, and tryptamines". Psychopharmacology (Berl). 203 (2): 251–263. doi:10.1007/s00213-008-1356-8. PMID   18979087.
9. Mori T, Suzuki T (2018). "The Discriminative Stimulus Properties of Hallucinogenic and Dissociative Anesthetic Drugs". The Behavioral Neuroscience of Drug Discrimination. Current Topics in Behavioral Neurosciences. Vol. 39. pp. 141–152. doi: 10.1007/7854_2016_29 . ISBN   978-3-319-98559-6. PMID   27586539.{{cite book}}: |journal= ignored (help)

Further reading

• Glennon, R.A.; Young, R. (2011). Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies. Wiley. ISBN   978-0-470-43352-2 . Retrieved 2 November 2024.