Company type | Public company |
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Nasdaq: NOTV | |
Industry | Pharmaceutical industry |
Founded | 1974 | as Bioanalytical Systems
Founder | Peter Kissinger |
Headquarters | Lafayette, Indiana, United States |
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Services | Contract research organization |
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Number of employees | 1,200+ (2020) |
Website | www |
Footnotes /references [1] |
Animal testing |
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Inotiv, Inc. is a contract research organization organized in Indiana and headquartered in Lafayette, Indiana. The company operates two core business units: Discovery and Safety Assessment (DSA) and Research Models and Services (RMS). The CRS business unit offers drug development and environmental sciences services, including safety assessment, analytical, metabolism, CMC and regulatory consultancy for small molecule drug candidates, biotherapeutics, and biomedical devices. The RMS business unit provides research models (live animals), lab animal diets and bedding and support services. [1]
The company has been criticized for its animal testing practices, most specifically animal testing on non-human primates as well as on beagles. It has also been criticized for its laboratory animal sources. In 2022, the United States Department of Agriculture found multiple violations of the Animal Welfare Act of 1966 at the company's dog-breeding facility in Cumberland, Virginia, to which the company plead guilty, resulting in $35 million in fines. The company is accredited by AAALAC International. [2]
In July 2018, Bioanalytical Systems, founded in 1974 by Purdue University chemistry professor Peter Kissinger, and Seventh Wave Laboratories, founded in 2003, merged. [3]
In March 2021, the company changed its name to Inotiv. The Inotiv brand had been launched in November 2019 for the company's contract research organization division. [4]
In November 2021, Inotiv acquired Envigo. [5] Envigo was formed in September 2015 by the merger of Huntingdon Life Sciences, Harlan Laboratories and three subsidiaries - GFA, NDA Analytics and LSR Associates. [6] It became a public company via a merger with a special-purpose acquisition company in August 2017. [7] [8] [9] In June 2019, it acquired the research products business of Fortrea, which acquired the nonclinical contract research services business of the company. [10] [11] In December 2019, it acquired the unit of Horizon Discovery that provides animals with clinically relevant gene deletions, insertions and other modifications for testing. [12]
In January 2022, the company acquired Integrated Laboratory Systems for $56 million. [13]
In February 2022, the company acquired Orient BioResource Center, a preclinical contract research organization and animal model supplier for $51 million. [14]
In August 2023, the company sold its Israeli business to Harlan Holdings for $3.7 million. [15]
The company owned and operated a research and breeding facility in Cumberland, Virginia that housed over 5,000 beagles, bred and sold for medical research. In 2019, PETA conducted an undercover investigation at the facility. [16] After a routine inspection in July 2021, USDA inspectors cited the company for 26 violations of the Animal Welfare Act of 1966. [17] After an inspection in October 2021, inspectors cited the company for 13 violations, including 11 repeat violations. [18] Inspectors noted in their reports that the dogs had inadequate food and water and veterinary care, more than 500 dogs were experiencing pain and discomfort, being left in 85-degree heat without air conditioning for up to five hours, and infrequent cleaning left kennels and feeders hounded by insects. More than a dozen dogs were found to have paw and eye injuries, as well as some with "severe dental disease". Over a seven-month period, more than 300 puppies died from "unknown causes", and the facility had kept unfinished records regarding their deaths. Nursing beagles were denied adequate food, and puppies were euthanized without anesthesia. [19] "Investigators observed "widespread fighting" between beagles sharing food sources ... [and] beagles fighting between adjacent cages ... In multiple enclosures, puppies were unable to access the spigots to get water on their own, and when the investigator 'held down the spigot to release water,' the puppies 'immediately rushed to the spigot to get water and drank heavily and quickly.'" [20] Investigators also found numerous beagles trapped in cage floors, one whose jaw was stuck in the cage bars, and unhygienic conditions including insects, mold and a buildup of old food. [21] [22]
As a result of these reports and undercover investigations by local news WRIC-TV and PETA, three bills were introduced in Virginia to tighten regulation and subject employees to criminal liability in January 2022; one of such bills passed in April 2022. [23] [24] [25]
After an inspection on March 8, 2022 found five repeat violations, including unsafe conditions, animal injuries, and mold and feces in the food supply, Virginia Senators Mark Warner and Tim Kaine sent a letter to the USDA requesting that the facility's license be temporarily revoked. [26]
The United States Department of Justice filed a complaint against the company in federal district court on May 19, 2022, seeking an injunction to stop the company from breeding, selling, or otherwise dealing in beagles at the facility. [27] U.S. District Court Judge Norman K. Moon granted the injunction. [28] [20] The government also seized nearly 150 beagles from the site that were in desperate need of medical treatment denied by the company. [29] [30]
In a settlement reached in July 2022, the company agreed to no longer engage in activities at the Cumberland site that require an Animal Welfare Act license and to relinquish the nearly 4,000 beagles at the facility to the Humane Society of the United States. [22] The company was also ordered to pay a portion of the adoption costs. [31] The remainder of the costs were covered by dog rescue charities. [32] This represented the largest animal welfare seizure in the history of the Humane Society. [33] The Humane Society transported the dogs to a network of shelters across the United States and by September 1, 2022, all of the dogs had been adopted. [34] [35] One of the beagles was adopted by Meghan, Duchess of Sussex and Prince Harry, Duke of Sussex. [36] Another rescued puppy was adopted by New Jersey Governor Phil Murphy and is now the First Dog of New Jersey. [37]
In June 2024, the company plead guilty to conspiring to violate the Animal Welfare Act of 1966 and conspiring to violate the Clean Water Act, agreeing to pay $22 million in fines, including the largest-ever fine imposed by the Department of Justice in an animal welfare case, as well as agreeing to pay an additional $13.5 million toward animal welfare and environmental projects, law enforcement expenses, and improvements to facilities. [38] [39]
In August 2023, the U.S. Securities and Exchange Commission investigated the company for possible violations of the Foreign Corrupt Practices Act for knowing using monkeys that were illegally captured in national parks and protected wild habitats. [40]
The beagle is a breed of small scent hound, similar in appearance to the much larger foxhound. The beagle was developed primarily for hunting rabbit or hare, known as beagling. Possessing a great sense of smell and superior tracking instincts, the beagle is the primary breed used as a detection dog for prohibited agricultural imports and foodstuffs in quarantine around the world. The beagle is a popular pet due to its size and good temper.
People for the Ethical Treatment of Animals is an American animal rights nonprofit organization based in Norfolk, Virginia, and led by Ingrid Newkirk, its international president.
The American Kennel Club (AKC) is a registry of purebred dog pedigrees in the United States. In addition to maintaining its pedigree registry, this kennel club also promotes and sanctions events for purebred dogs, including the Westminster Kennel Club Dog Show, an annual event which predates the official forming of the AKC, the National Dog Show and the AKC National Championship. The AKC is a non-member partner with the Fédération Cynologique Internationale. The AKC recognizes 200 dog breeds, as of 2022.
The American Society for the Prevention of Cruelty to Animals (ASPCA) is a non-profit organization dedicated to preventing animal cruelty. Based in New York City since its inception in 1866, the organization's mission is "to provide effective means for the prevention of cruelty to animals throughout the United States."
A puppy mill, also known as a puppy farm, is a commercial dog breeding facility characterized by quick breeding and poor conditions. Although no standardized legal definition for "puppy mill" exists, a definition was established in Avenson v. Zegart in 1984 as "a dog breeding operation in which the health of the dogs is disregarded to maintain a low overhead and maximize profits". They are cited as being a result of increased demand for household pets, especially after World War II. The Veterinary Medical Association of the Humane Society of the United States defines the main characteristics of a puppy mill as "emphasis on quantity over quality, indiscriminate breeding, continuous confinement, lack of human contact and environmental enrichment, poor husbandry, and minimal to no veterinary care."
Huntingdon Life Sciences (HLS) was a contract research organisation (CRO) organized in Maryland and headquartered in East Millstone, New Jersey. It was founded in 1951 in Cambridgeshire, England. It had two laboratories in the United Kingdom and one in the United States. With over 1,600 employees, it was the largest non-clinical CRO in Europe and the third-largest non-clinical CRO in the world. In September 2015, Huntingdon Life Sciences, Harlan Laboratories, GFA, NDA Analytics and LSR associates merged into Envigo.
Dog breeding is the practice of mating selected dogs with the intention of maintaining or producing specific qualities and characteristics. When dogs reproduce without such human intervention, their offspring's characteristics are determined by natural selection, while "dog breeding" refers specifically to the artificial selection of dogs, in which dogs are intentionally bred by their owners. Breeding relies on the science of genetics, hence a breeder who is knowledgeable on canine genetics, health, and the intended purpose of the dogs attempts to breed suitable dogs.
Dog crossbreeds are dogs which have been intentionally bred from two or more recognized dog breeds. They are not dogs with no purebred ancestors, but are not otherwise recognised as breeds in their own right, and do not necessarily breed true.
Fortrea Holdings Inc. is a contract research organization organized in Delaware and headquartered in Durham, North Carolina with operations in 90 countries. It customers are primarily in the pharmaceutical, biotechnology, and medical device industries.
The Animal Welfare Act was signed into law by President Lyndon B. Johnson on August 24, 1966. It is the main federal law in the United States that regulates the treatment of animals in research and exhibition. Other laws, policies, and guidelines may include additional species coverage or specifications for animal care and use, but all refer to the Animal Welfare Act as the minimally acceptable standard for animal treatment and care. The USDA and APHIS oversee the AWA and the House and Senate Agriculture Committees have primary legislative jurisdiction over the Act. Animals covered under this Act include any live or dead cat, dog, hamster, rabbit, nonhuman primate, guinea pig, and any other warm-blooded animal determined by the Secretary of Agriculture for research, pet use or exhibition. Excluded from the Act are birds, rats of the genus Rattus, mice of the genus Mus, farm animals, and all cold-blooded animals.
Charles River Laboratories International, Inc., is an American pharmaceutical company specializing in a variety of preclinical and clinical laboratory, gene therapy and cell therapy services for the pharmaceutical, medical device and biotechnology industries. It also supplies assorted biomedical products, outsourcing services, and animals for research and development in the pharmaceutical industry and offers support in the fields of basic research, drug discovery, safety and efficacy, clinical support, and manufacturing.
Shamrock Farm was the United Kingdom's only non-human primate importation and quarantine centre, located in Small Dole, near Henfield in West Sussex. The centre, owned by Bausch and Lomb and run by Charles River Laboratories, Inc. for Shamrock (GB) Ltd, provided animals to various laboratories and universities for use in animal testing. It was Europe's largest supplier of primates to laboratories, and held up to 350 monkeys at a time.
The Seeing Eye, Inc. is a guide dog school located in Morris Township, New Jersey, in the United States. Founded in 1929, the Seeing Eye is the oldest guide dog school in the U.S., and one of the largest.
Guiding Eyes for the Blind is a non-profit school based in Yorktown Heights, New York that trains guide dogs to aid people who are visually impaired. It also operates a canine development center in Patterson, New York, and a training site in White Plains, New York. It was the first guide dog training school to be accredited by the National Accreditation Council for Agencies Serving the Blind and Visually Handicapped.
Animals used by laboratories for testing purposes are largely supplied by dealers who specialize in selling them to universities, medical and veterinary schools, and companies that provide contract animal-testing services. It is comparatively rare that animals are procured from sources other than specialized dealers, as this poses the threat of introducing disease into a colony and confounding any data collected. However, suppliers of laboratory animals may include breeders who supply purpose-bred animals, businesses that trade in wild animals, and dealers who supply animals sourced from pounds, auctions, and newspaper ads. Animal shelters may also supply the laboratories directly. Some animal dealers, termed Class B dealers, have been reported to engage in kidnapping pets from residences or illegally trapping strays, a practice dubbed as bunching.
Petland is a privately owned operator and franchisor of pet stores based in Chillicothe, Ohio. Ed Kunzelman founded the company in 1967. Petland currently operates 131 stores in the United States, and at least 63 in foreign markets including Canada, Japan, China, Mexico, Brazil and El Salvador. The chain is notable for its controversy over documentation from the Humane Society of the United States revealing the purchase of dogs from puppy mills.
Harlan Sprague Dawley Inc. was a supplier of animals and other services to laboratories for the purpose of animal testing. It provided pre-clinical research tools and services for the pharmaceutical, biotechnology, agrochemicals, industrial chemical, and food industries.
Animal welfare in the United States relates to the treatment of non-human animals in fields such as agriculture, hunting, medical testing and the domestic ownership of animals. It is distinct from animal conservation.
National Mill Dog Rescue (NMDR) is a non-profit organization based in Peyton, Colorado. It was established by Theresa Strader in February 2007, and legally incorporated on July 23, 2007. According to the organization's website, it aims to "rescue, rehabilitate and rehome discarded breeding dogs and to educate the general public about the cruel realities of the commercial dog breeding industry".
Camp Beagle is an ongoing protest camp set up in June 2021 by animal rights activists outside of MBR Acres, a breeding facility for beagles used in laboratory research, in Wyton, Cambridgeshire. As of May 2024, It is the longest-lasting protest camp of its kind, where protesters have maintained a permanent presence, as they want the site to be closed down.