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TIHKAL: The Continuation
Cover of TIHKAL, 1st ed.
Author Alexander and Ann Shulgin
CountryUnited States
Subject Pharmacology, Autobiography, Psychedelic drugs
PublisherTransform Press
Publication date
Media typePaperback
Pagesxxviii, 804 p.
ISBN 0-9630096-9-9
OCLC 38503252
Preceded by PIHKAL  

TIHKAL: The Continuation is a 1997 book written by Alexander Shulgin and Ann Shulgin about a family of psychoactive drugs known as tryptamines. A sequel to PIHKAL: A Chemical Love Story , TIHKAL is an acronym that stands for "Tryptamines I Have Known and Loved".



TIHKAL, much like its predecessor PIHKAL, is divided into two parts. The first part, for which all rights are reserved, begins with a fictionalized autobiography, picking up where the similar section of PIHKAL left off; it then continues with a collection of essays on topics ranging from psychotherapy and the Jungian mind to the prevalence of DMT in nature, ayahuasca and the War on Drugs. The second part of TIHKAL, which may be conditionally distributed for non-commercial reproduction (see external links below), is a detailed synthesis manual for 55 psychedelic compounds (many discovered by Alexander Shulgin himself), including their chemical structures, dosage recommendations, and qualitative comments. Shulgin has made the second part freely available on Erowid.org while the first part is available only in the printed text.

Like PIHKAL, the Shulgins were motivated to release the synthesis information as a way to protect the public's access to information about psychedelic compounds, a goal Alexander Shulgin has noted many times. [1] Following a raid of his laboratory in 1994 by the United States DEA, [2] Richard Meyer, spokesman for DEA's San Francisco Field Division, stated that "It is our opinion that those books [referring to the previous work, PIHKAL ] are pretty much cookbooks on how to make illegal drugs. Agents tell me that in clandestine labs that they have raided, they have found copies of those books."

Tryptamines listed

SubstanceChemical name
1 AL-LAD 6-Allyl-N,N-diethyl-NL
2 DBT N,N-Dibutyl-T
3 DET N,N-Diethyl-T
4 DiPT N,N-Diisopropyl-T
5 alpha,O-DMS 5-Methyoxy-alpha-methyl-T
6 DMT N,N-Dimethyl-T
7 2,alpha-DMT 2,alpha-Dimethyl-T
8 alpha,N-DMT alpha,N-Dimethyl-T
9 DPT N,N-Dipropyl-T
10 EiPT N-Ethyl-N-isopropyl-T
11 AET alpha-Ethyl-T
12 ETH-LAD 6,N,N-Triethyl-NL
13 Harmaline 3,4-Dihydro-7-methoxy-1-methyl-C
14 Harmine 7-Methyoxy-1-methyl-C
15 4-HO-DBT N,N-Dibutyl-4-hydroxy-T
16 4-HO-DET N,N-Diethyl-4-hydroxy-T
17 4-HO-DiPT N,N-Diisopropyl-4-hydroxy-T
18 4-HO-DMT N,N-Dimethyl-4-hydroxy-T
19 5-HO-DMT N,N-Dimethyl-5-hydroxy-T
20 4-HO-DPT N,N-Dipropyl-4-hydroxy-T
21 4-HO-MET N-Ethyl-4-hydroxy-N-methyl-T
22 4-HO-MiPT 4-Hydroxy-N-isopropyl-N-methyl-T
23 4-HO-MPT 4-Hydroxy-N-methyl-N-propyl-T
24 4-HO-pyr-T 4-Hydroxy-N,N-tetramethylene-T
25 Ibogaine A complexly substituted-T
26 LSD N,N-Diethyl-L
27 MBT N-Butyl-N-methyl-T
28 4,5-MDO-DiPT N,N-Diisopropyl-4,5-methylenedioxy-T
29 5,6-MDO-DiPT N,N-Diisopropyl-5,6-methylenedioxy-T
30 4,5-MDO-DMT N,N-Dimethyl-4,5-methylenedioxy-T
31 5,6-MDO-DMT N,N-Dimethyl-5,6-methylenedioxy-T
32 5,6-MDO-MiPT N-Isopropyl-N-methyl-5,6-methylenedioxy-T
33 2-Me-DET N,N-Diethyl-2-methyl-T
34 2-Me-DMT 2,N,N-Trimethyl-T
35 Melatonin N-Acetyl-5-methoxy-T
36 5-MeO-DET N,N-Diethyl-5-methoxy-T
37 5-MeO-DiPT N,N-Diisopropyl-5-methoxy-T
38 5-MeO-DMT 5-Methoxy-N,N-dimethyl-T
39 4-MeO-MiPT N-Isopropyl-4-methoxy-N-methyl-T
40 5-MeO-MiPT N-Isopropyl-5-methoxy-N-methyl-T
41 5,6-MeO-MiPT 5,6-Dimethoxy-N-isopropyl-N-methyl-T
42 5-MeO-NMT 5-Methoxy-N-methyl-T
43 5-MeO-pyr-T 5-Methoxy-N,N-tetramethylene-T
44 6-MeO-THH 6-Methoxy-1-methyl-1,2,3,4-tetrahydro-C
45 5-MeO-TMT 5-Methoxy-2,N,N-trimethyl-T
46 5-MeS-DMT N,N-Dimethyl-5-methylthio-T
47 MiPT N-Isopropyl-N-methyl-T
48 a-MT alpha-Methyl-T
49 NET N-Ethyl-T
50 NMT N-Methyl-T
51 PRO-LAD 6-Propyl-NL
52 pyr-T N,N-Tetramethylene-T
53 T Tryptamine
54 Tetrahydroharmine 7-Methoxy-1-methyl-1,2,3,4-tetrahydro-C
55 alpha,N,O-TMS alpha,N-Dimethyl-5-methoxy-T

See also


  1. Bennett, Drake (January 30, 2005). "Dr. Ecstasy". New York Times Magazine. Retrieved July 8, 2006.
  2. "DEA Raid of Shulgin's Laboratory". Erowid. January 8, 2004. Retrieved July 8, 2006.

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<span class="mw-page-title-main">Alexander Shulgin</span> American medicinal chemist (1925–2014)

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<span class="mw-page-title-main">2C-T-7</span> Chemical compound

2C-T-7 is a psychedelic phenethylamine of the 2C family. In his book PiHKAL: A Chemical Love Story, Alexander Shulgin lists the dosage range as 10 to 30 mg. 2C-T-7 is generally taken orally, and produces psychedelic and entactogenic effects that last 8 to 15 hours. Up until Operation Web Tryp and three deaths, two of which involved the use of other drugs in addition to 2C-T-7, and one which involved an excessive insufflated dose, 2C-T-7 was sold commercially in Dutch and Japanese smartshops and online. It is known on the streets as Blue Mystic or 7th Heaven. There has been little real research done on this chemical other than Shulgin's comments in PiHKAL and a few small animal studies mostly aimed at detecting metabolites.

<span class="mw-page-title-main">2C-E</span> Chemical compound

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<i>alpha</i>-Ethyltryptamine Chemical compound

α-Ethyltryptamine, also known as etryptamine, is a psychedelic, stimulant, and entactogenic drug of the tryptamine class. It was originally developed and marketed as an antidepressant under the brand name Monase by Upjohn in the 1960s.

<span class="mw-page-title-main">4-HO-DiPT</span> Chemical compound

4-Hydroxy-N,N-diisopropyltryptamine is a synthetic psychedelic drug. It is a higher homologue of psilocin, 4-HO-DET, and is a positional isomer of 4-HO-DPT and has a tryptamine molecular sub-structure.

<span class="mw-page-title-main">2C-T-8</span> Chemical compound

2C-T-8 is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin, sometimes used as an entheogen.

<span class="mw-page-title-main">Ann Shulgin</span> American author (1931–2022)

Laura Ann Shulgin was an American author and the wife of chemist Alexander Shulgin, with whom she wrote PiHKAL and TiHKAL.

<span class="mw-page-title-main">4-HO-MiPT</span> Chemical compound

4-HO-MiPT is a synthetic substituted aromatic compound and a lesser-known psychedelic tryptamine. It is thought to be a serotonergic psychedelic, similar to magic mushrooms, LSD and mescaline. Its molecular structure and pharmacological effects somewhat resemble those of the tryptamine psilocin, which is the primary psychoactive chemical in magic mushrooms.

<span class="mw-page-title-main">2C-T</span> Chemical compound

2C-T is a psychedelic and hallucinogenic drug of the 2C family. It is used by some as an entheogen. It has structural and pharmacodynamic properties similar to the drugs mescaline and 2C-T-2.

<span class="mw-page-title-main">2,N,N-TMT</span> Chemical compound

2,N,N-trimethyltryptamine, 2,N,N-TMT, or 2-Me-DMT is a tryptamine derivative that is a psychedelic drug. It was invented by Alexander Shulgin and reported in his book TiHKAL (#34). It is claimed to show psychoactive effects at a dosage of 50–100 mg orally, but these are relatively mild compared to other similar drugs, suggesting that while the 2-methyl group has blocked the binding of metabolic enzymes, it is also interfering with binding to the 5HT2A receptor target that mediates the hallucinogenic effects of these drugs.

<span class="mw-page-title-main">5-MeO-2-TMT</span> Chemical compound

5-Methoxy-2,N,N-trimethyltryptamine is a psychoactive drug of the tryptamine chemical class which acts as a psychedelic. It was first synthesized by Alexander Shulgin and reported in his book TiHKAL. 5-MeO-TMT is claimed to show psychoactive effects at a dosage of 75–150 mg orally, but these are relatively mild compared to those of other similar compounds. This suggests that while the methyl group on the 2-position of the molecule has impaired the binding of metabolic enzymes like monoamine oxidase (MAO), it is also interfering with binding to and/or activation of the serotonin 5-HT2A receptor, the target responsible for mediating the hallucinogenic effects of such compounds.

<span class="mw-page-title-main">MMDA-2</span> Psychedelic drug

MMDA-2 (2-methoxy-4,5-methylenedioxyamphetamine) is a psychedelic drug of the amphetamine class. It is closely related to MMDA and MDA.

<span class="mw-page-title-main">4-HO-MPT</span> Chemical compound

4-Hydroxy-N-methyl-N-propyltryptamine, commonly known as 4-HO-MPT or meprocin, is a psychedelic drug in the tryptamine class of chemical compounds and is a higher homologue of the naturally occurring substituted tryptamine psilocin as well as being the 4-hydroxyl analog of MPT.

<span class="mw-page-title-main">4-HO-pyr-T</span> Chemical compound

4-HO-pyr-T (4-hydroxy-N,N-tetramethylenetryptamine) is a lesser-known psychedelic drug. It is the 4-hydroxyl analog of pyr-T. 4-HO-pyr-T was first synthesized by Alexander Shulgin. In his book TiHKAL, neither the dosage nor the duration are reported. 4-HO-pyr-T produces few to no effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-pyr-T.

<span class="mw-page-title-main">Pyr-T</span> Chemical compound

Pyr-T (N,N-tetramethylenetryptamine) is a lesser-known, possible psychedelic drug. Pyr-T was first characterized by S. Mitzal. Toxicity testing was later performed by Hunt and Brimblecombe, and although a lethal dosage was found in rats, a value is not given. In the book TiHKAL, neither the dosage nor the duration are reported.

<span class="mw-page-title-main">2,α-Dimethyltryptamine</span> Chemical compound

2,α-Dimethyltryptamine (2,α-DMT) is a tryptamine and a lesser-known psychedelic drug. It is the 2,α-dimethyl analog of DMT. Its synthesis was first reported in 1965. Alexander Shulgin lists the dosage as 300-500 mg, and the duration as 7–10 hours in his book TiHKAL. 2,α-DMT causes mydriasis and paresthesia. It also produces a calm, drunk-like feeling. Very little data exists about the pharmacological properties, metabolism, and toxicity of 2,α-DMT.

<span class="mw-page-title-main">Alpha,N-DMT</span> Chemical compound

Alpha,N-DMT, or α,N-dimethyltryptamine, is a lesser-known psychedelic drug. It is the α,N-dimethyl analog of DMT. α,N-DMT was first synthesized by Alexander Shulgin. In his book TiHKAL, Shulgin lists the dosage as 50-100 mg, and the duration as 6–8 hours. α,N-DMT causes an unpleasant body load. Very little data exists about the pharmacological properties, metabolism, and toxicity of α,N-DMT. α,N-DMT is known to be a potent monoamine oxidase inhibitor

<span class="mw-page-title-main">Alpha,N,O-TMS</span> Chemical compound

Alpha,N,O-TMS, or α,N-dimethyl-5-methoxytryptamine, is a lesser-known psychedelic drug. Its abbreviated nomenclature is derived from its structure, as it is α,N,O-trimethyl serotonin. α,N,O-TMS was first synthesized by Alexander Shulgin. In his book TiHKAL, Shulgin lists the dosage as 10-20 mg when taken orally, and the duration as 6–8 hours.

<span class="mw-page-title-main">4-HO-αMT</span> Chemical compound

4-Hydroxy-α-methyltryptamine (4-HO-αMT) is a psychedelic drug of the tryptamine class. It is a close structural analogue of α-methyltryptamine (αMT) and produces similar effects to it, but with exacerbated side effects similarly to 5-MeO-αMT. Alexander Shulgin describes 4-HO-αMT briefly in his book TiHKAL:

The 4-hydroxy analogue of αMT has been looked at in human subjects. It is reported to be markedly visual in its effects, with some subjects reporting dizziness and a depressed feeling. There were, however, several toxic signs at doses of 15 to 20 milligrams orally, including abdominal pain, tachycardia, increased blood pressure and, with several people, headache and diarrhea.