HU-345

HU-345

Identifiers
IUPAC name 6,6,9-Trimethyl-3-pentyl-1H-benzo[c]chromene-1,4(6H)-dione
CAS Number	731773-46-9  Y
PubChem CID	11198119
ChemSpider	9373188  Y
ChEMBL	ChEMBL127671  Y
CompTox Dashboard (EPA)	DTXSID101029797
Chemical and physical data
Formula	C21H24O3
Molar mass	324.420 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C2\C(=C/C(=O)C=3c1c(ccc(c1)C)C(OC2=3)(C)C)CCCCC
InChI InChI=1S/C21H24O3/c1-5-6-7-8-14-12-17(22)18-15-11-13(2)9-10-16(15)21(3,4)24-20(18)19(14)23/h9-12H,5-8H2,1-4H3 Y Key:UFDYTRQMIXJHTH-UHFFFAOYSA-N Y
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HU-345 (cannabinol quinone) is a drug that is able to inhibit aortic ring angiogenesis more potently than the parent compound cannabinol (CBN). ^{[1] [2]} It exhibits no psychoactive effects.

HU-345 is made via the oxidation of CBN. ^[3]

See also

• HU-331
• HU-336

References

1. Kogan NM, Blázquez C, Alvarez L, Gallily R, Schlesinger M, Guzmán M, Mechoulam R (July 2006). "A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells". Molecular Pharmacology. 70 (1): 51–59. doi:10.1124/mol.105.021089. PMID   16571653. S2CID   4830577.
2. US patent 0092584, Mechoulam R, Kogan NM, Rabinowitz R, Schlesinger M, "Therapeutic Use of Quinonoid Derivatives of Cannabinoids", granted 2011-04-21 
3. Kogan NM, Peters M, Mechoulam R (March 2021). "Cannabinoid Quinones-A Review and Novel Observations". Molecules. 26 (6): 1761. doi: 10.3390/molecules26061761 . PMC   8003933 . PMID   33801057.