JTE-907

JTE-907

Legal status
Legal status	CA: Schedule II
Identifiers
IUPAC name N-(benzo[1,3]dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxamide
CAS Number	282089-49-0  Y
PubChem CID	9867770
ChemSpider	8043461
UNII	DAV3Q7SNOL
CompTox Dashboard (EPA)	DTXSID001010010
ECHA InfoCard	100.209.196
Chemical and physical data
Formula	C24H26N2O6
Molar mass	438.480 g·mol−1
3D model (JSmol)	Interactive image
SMILES c4c3OCOc3ccc4CNC(=O)c(cc2ccc1OC)c(=O)[nH]c2c1OCCCCC
InChI InChI=1S/C24H26N2O6/c1-3-4-5-10-30-22-19(29-2)9-7-16-12-17(24(28)26-21(16)22)23(27)25-13-15-6-8-18-20(11-15)32-14-31-18/h6-9,11-12H,3-5,10,13-14H2,1-2H3,(H,25,27)(H,26,28) Key:GRAJFFFXJYFVOC-UHFFFAOYSA-N
(verify)

JTE-907 is a drug used in scientific research that acts as a selective CB₂ inverse agonist. ^{[1] [2]} It has antiinflammatory effects in animal studies, ^[3] thought to be mediated by an interaction between the CB₂ receptor and IgE. ^[4]

See also

• JTE 7-31

References

1. Iwamura H, Suzuki H, Ueda Y, Kaya T, Inaba T (February 2001). "In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor". The Journal of Pharmacology and Experimental Therapeutics. 296 (2): 420–5. doi:10.1016/S0022-3565(24)38760-9. PMID   11160626.
2. Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T (March 2006). "Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists". Journal of Medicinal Chemistry. 49 (6): 2022–7. doi:10.1021/jm050879z. PMID   16539390.
3. Ueda Y, Miyagawa N, Matsui T, Kaya T, Iwamura H (September 2005). "Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice". European Journal of Pharmacology. 520 (1–3): 164–71. doi:10.1016/j.ejphar.2005.08.013. PMID   16153638.
4. Ueda Y, Miyagawa N, Wakitani K (January 2007). "Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice". Life Sciences. 80 (5): 414–9. doi:10.1016/j.lfs.2006.09.026. PMID   17055000.