APP-FUBINACA

APP-FUBINACA

Legal status
Legal status	CA: Schedule II DE: NpSG (Industrial and scientific use only) UK: Class B
Identifiers
IUPAC name N-(1-amino-3-phenyl-1-oxopropan-2-yl)-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide
CAS Number	1185282-03-4  Y
PubChem CID	58124515
ChemSpider	58789142
UNII	TW71LSK9DG
CompTox Dashboard (EPA)	DTXSID501032568
Chemical and physical data
Formula	C24H21FN4O2
Molar mass	416.456 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(N[C@H](C(N)=O)CC1=CC=CC=C1)C2=NN(CC3=CC=C(F)C=C3)C4=C2C=CC=C4
InChI InChI=1S/C24H21FN4O2/c25-18-12-10-17(11-13-18)15-29-21-9-5-4-8-19(21)22(28-29)24(31)27-20(23(26)30)14-16-6-2-1-3-7-16/h1-13,20H,14-15H2,(H2,26,30)(H,27,31)/t20-/m0/s1 Key:TZXBEYFALIFOAG-FQEVSTJZSA-N

APP-FUBINACA is an indazole-based synthetic cannabinoid that has been sold online as a designer drug. ^[1] Pharmacological testing showed APP-FUBINACA to have only moderate affinity for the CB₁ receptor, with a Ki of 708 nM, while its EC₅₀ was not tested. ^[2] It contains a phenylalanine amino acid residue in its structure. ^[3]

Legality

Sweden's public health agency suggested to classify APP-FUBINACA as hazardous substance on March 24, 2015. ^[4]

See also

• 5F-AB-PINACA
• 5F-ADB
• 5F-AMB
• 5F-APINACA
• AB-FUBINACA
• AB-CHFUPYCA
• AB-CHMINACA
• AB-PINACA
• ADB-CHMINACA
• ADB-FUBINACA
• ADB-PINACA
• ADBICA
• APICA
• APINACA
• APP-BINACA ^[5]
• BMS-F
• MDMB-CHMICA
• MDMB-FUBINACA
• PX-1
• PX-2
• PX-3

References

1. "APP-FUBINACA". Cayman Chemical. Retrieved 15 July 2015.
2. WO 2009106982,Buchler IP, Hayes MJ, Hedge SG, Hockerman SL, Jones DL, Kortum SW, Rico JG, Tenbrink RE, Wu KK,"Indazole derivatives",published 3 September 2009, assigned to Pfizer Inc 
3. Evelyn, Alex. "HHC (Hexahydrocannabinol)" . Retrieved 19 December 2021.
4. "Fler ämnen föreslås bli klassade som narkotika eller hälsofarlig vara". Folkhälsomyndigheten. Retrieved 16 July 2015.
5. Cannaert A, Sparkes E, Pike E, Luo JL, Fang A, Kevin RC, et al. (December 2020). "in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA". ACS Chemical Neuroscience. 11 (24): 4434–4446. doi:10.1021/acschemneuro.0c00644. PMID   33253529. S2CID   227246346.