CB-86

Last updated

CB-86
CB-86 structure.png
Identifiers
  • N-cyclopropyl-8-[3-hydroxy-5-(2-methyloctan-2-yl)phenoxy]octanamide
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
Formula C26H43NO3
Molar mass 417.634 g·mol−1
3D model (JSmol)
  • CCCCCCC(C)(C)C1=CC(=CC(=C1)OCCCCCCCC(=O)NC2CC2)O
  • InChI=1S/C26H43NO3/c1-4-5-6-11-16-26(2,3)21-18-23(28)20-24(19-21)30-17-12-9-7-8-10-13-25(29)27-22-14-15-22/h18-20,22,28H,4-17H2,1-3H3,(H,27,29)
  • Key:PVAOGZXUOOHSMN-UHFFFAOYSA-N

CB-86 is a synthetic cannabinoid drug which was developed as a hybrid between classical/nonclassical cannabinoids such as THC and CP 47,497 with endogenous cannabinoid ligands such as anandamide. It acts as a partial agonist at CB1 receptors with a Ki of 5.6 nM, and an antagonist of CB2 receptors with a Ki of 7.9 nM. It has analgesic effects in studies on mice. [1]

See also

References

  1. ↑ Brizzi A, Brizzi V, Cascio MG, Corelli F, Guida F, Ligresti A, et al. (April 2009). "New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo". Journal of Medicinal Chemistry. 52 (8): 2506–2514. doi:10.1021/jm8016255. PMID   19331413.
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