5F-NNE1

5F-NNE1

Legal status
Legal status	CA: Schedule II DE: NpSG (Industrial and scientific use only) UK: Class B
Identifiers
IUPAC name 1-(5-Fluoropentyl)-N-(naphthalen-1-yl)-1H-indole-3-carboxamide
CAS Number	1445580-60-8
PubChem CID	118796566
ChemSpider	29341632
UNII	3T22QDP4D9
CompTox Dashboard (EPA)	DTXSID901032710
Chemical and physical data
Formula	C24H23FN2O
Molar mass	374.459 g·mol−1
3D model (JSmol)	Interactive image
SMILES FCCCCCn1cc(c2c1cccc2)C(=O)Nc1cccc2c1cccc2
InChI InChI=1S/C24H23FN2O/c25-15-6-1-7-16-27-17-21(20-12-4-5-14-23(20)27)24(28)26-22-13-8-10-18-9-2-3-11-19(18)22/h2-5,8-14,17H,1,6-7,15-16H2,(H,26,28) Key:DJKVOBZLMBHFKX-UHFFFAOYSA-N

5F-NNE1 (also known as 5F-NNEI and 5F-MN-24) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor and has been sold online as a designer drug. ^{[1] [2]} Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of 5F-NNE1 may release 1-naphthylamine, a known carcinogen.

Legality

Sweden's public health agency suggested classifying 5F-NNE1 as hazardous substance on November 10, 2014. ^[3]

See also

• 5F-ADBICA
• 5F-SDB-006
• AM-2201
• FDU-NNE1
• FUB-144
• MMB-2201
• NNE1
• PX-1

References

1. "5F-NNEI". Southern Association of Forensic Scientists. Archived from the original on 27 May 2015. Retrieved 24 July 2015.
2. Wohlfarth A, Castaneto MS, Zhu M, Pang S, Scheidweiler KB, Kronstrand R, Huestis MA (May 2015). "Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA". The AAPS Journal. 17 (3): 660–77. doi:10.1208/s12248-015-9721-0. PMC   4406957 . PMID   25721194.
3. "Cannabinoider föreslås bli klassade som hälsofarlig vara". Folkhälsomyndigheten. Retrieved 24 July 2015.