LPAR6

LPAR6
Identifiers
Aliases	LPAR6 , ARWH1, HYPT8, LAH3, P2RY5, P2Y5, lysophosphatidic acid receptor 6, LPA-6
External IDs	OMIM: 609239 MGI: 1914418 HomoloGene: 55925 GeneCards: LPAR6
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q14.2 Start 48,389,567 bp [1] End 48,444,704 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 D3 Start 73,475,335 bp [2] End 73,480,734 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte minor salivary gland cavity of mouth vagina Achilles tendon gallbladder lactiferous duct cervix epithelium prostate seminal vesicula Top expressed in hand hair follicle brown adipose tissue medullary collecting duct mammary gland otolith organ utricle skin of abdomen maxillary prominence abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity lysophosphatidic acid receptor activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane intracellular membrane-bounded organelle Biological process signal transduction positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway G protein-coupled receptor signaling pathway blastocyst hatching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10161 67168 Ensembl ENSG00000139679 ENSMUSG00000033446 UniProt P43657 Q8BMC0 RefSeq (mRNA) NM_005767 NM_001162497 NM_001162498 NM_001377316 NM_001377317 NM_175116 RefSeq (protein) NP_001155969 NP_001155970 NP_005758 NP_001364245 NP_001364246 NP_780325 Location (UCSC) Chr 13: 48.39 – 48.44 Mb Chr 14: 73.48 – 73.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lysophosphatidic acid receptor 6, also known as LPA₆, P2RY5 and GPR87, is a protein that in humans is encoded by the LPAR6 gene. ^{[5] [6] [7] [8]} LPA₆ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA). ^{[9] [10]}

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. ^[8]

Role in hair growth/loss

In February 2008, researchers at the University of Bonn announced they have found the genetic basis of two distinct forms of inherited hair loss, opening a broad path to treatments for baldness. They found that mutations in the gene P2RY5 causes a rare, inherited form of hair loss called hypotrichosis simplex. It is the first receptor in humans known to play a role in hair growth. The fact that any receptor plays a specific role in hair growth was previously unknown to scientists, and with this new knowledge a focus on finding more of these genes may be able to lead to therapies for many different types of hair loss. ^{[9] [11]}

In 2013, it was found that mutations in LPAR6 give rise to the Cornish Rex cat breed, which has a form of ectodermal dysplasia characterised by short woolly hair which is susceptible to loss. ^[12]

See also

• Lysophospholipid receptor
• P2Y receptor

References

1. GRCh38: Ensembl release 89: ENSG00000139679 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033446 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (Sep 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochim Biophys Acta. 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID   11004484.
6. Ralevic V, Burnstock G (Nov 1998). "Receptors for purines and pyrimidines". Pharmacol Rev. 50 (3): 413–92. PMID   9755289.
7. Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, Taguchi R, Shimizu T, Ishii S (Jun 2009). "Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6". J Biol Chem. 284 (26): 17731–41. doi: 10.1074/jbc.M808506200 . PMC   2719412 . PMID   19386608.
8. "Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5".
9. Pasternack SM, von Kügelgen I, Aboud KA, Lee YA, Rüschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Betz RC (March 2008). "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth". Nat. Genet. 40 (3): 329–34. doi:10.1038/ng.84. PMID   18297070. S2CID   20241237.
10. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID   20055701.
11. "Hypotrichosis simplex - About the Disease - Genetic and Rare Diseases Information Center". rarediseases.info.nih.gov. Retrieved 2023-05-06.
12. Gandolfi, Barbara; Alhaddad, Hasan; Affolter, Verena K.; Brockman, Jeffrey; Haggstrom, Jens; Joslin, Shannon E. K.; Koehne, Amanda L.; Mullikin, James C.; Outerbridge, Catherine A. (2013-06-27). "To the Root of the Curl: A Signature of a Recent Selective Sweep Identifies a Mutation That Defines the Cornish Rex Cat Breed". PLOS ONE. 8 (6): e67105. Bibcode:2013PLoSO...867105G. doi: 10.1371/journal.pone.0067105 . ISSN   1932-6203. PMC   3694948 . PMID   23826204.

Further reading

• Toguchida J, McGee TL, Paterson JC, et al. (1993). "Complete genomic sequence of the human retinoblastoma susceptibility gene". Genomics. 17 (3): 535–43. doi:10.1006/geno.1993.1368. PMID   7902321.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Herzog H, Darby K, Hort YJ, Shine J (1997). "Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene". Genome Res. 6 (9): 858–61. doi: 10.1101/gr.6.9.858 . PMID   8889552.
• Li Q, Schachter JB, Harden TK, Nicholas RA (1997). "The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses". Biochem. Biophys. Res. Commun. 236 (2): 455–60. doi:10.1006/bbrc.1997.6984. PMID   9240460.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC   2665288 . PMID   15057823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ihara H, Hirukawa K, Goto S, Togari A (2005). "ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts". Biochem. Biophys. Res. Commun. 326 (2): 329–34. doi:10.1016/j.bbrc.2004.11.037. PMID   15582581.

External links

• LPAR6 human gene location in the UCSC Genome Browser .
• LPAR6 human gene details in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.