LPAR6

Last updated

LPAR6
Identifiers
Aliases LPAR6 , ARWH1, HYPT8, LAH3, P2RY5, P2Y5, lysophosphatidic acid receptor 6, LPA-6
External IDs OMIM: 609239; MGI: 1914418; HomoloGene: 55925; GeneCards: LPAR6; OMA:LPAR6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005767
NM_001162497
NM_001162498
NM_001377316
NM_001377317

Contents

NM_175116

RefSeq (protein)

NP_001155969
NP_001155970
NP_005758
NP_001364245
NP_001364246

NP_780325

Location (UCSC) Chr 13: 48.39 – 48.44 Mb Chr 14: 73.48 – 73.48 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lysophosphatidic acid receptor 6, also known as LPA6, P2RY5 and GPR87, is a protein that in humans is encoded by the LPAR6 gene. [5] [6] [7] [8] LPA6 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA). [9] [10]

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. [8]

Role in hair growth/loss

In February 2008, researchers at the University of Bonn announced they have found the genetic basis of two distinct forms of inherited hair loss, opening a broad path to treatments for baldness. They found that mutations in the gene P2RY5 causes a rare, inherited form of hair loss called hypotrichosis simplex. It is the first receptor in humans known to play a role in hair growth. The fact that any receptor plays a specific role in hair growth was previously unknown to scientists, and with this new knowledge a focus on finding more of these genes may be able to lead to therapies for many different types of hair loss. [9] [11]

In 2013, it was found that mutations in LPAR6 give rise to the Cornish Rex cat breed, which has a form of ectodermal dysplasia characterised by short woolly hair which is susceptible to loss. [12]

See also

Related Research Articles

P2Y<sub>12</sub> Protein-coding gene in the species Homo sapiens

P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) that belongs to the Gi class of a group of G protein-coupled (GPCR) purinergic receptors. This P2Y receptor family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. The P2Y12 receptor is involved in platelet aggregation and is thus a biological target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.

<span class="mw-page-title-main">P2Y receptor</span> Subclass of purinergic P2 receptors

P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as adenosine triphosphate, adenosine diphosphate, uridine triphosphate, uridine diphosphate and UDP-glucose.To date, 8 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14.

<span class="mw-page-title-main">P2RY1</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.

<span class="mw-page-title-main">P2RY2</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.

<span class="mw-page-title-main">GPR98</span> Protein-coding gene in the species Homo sapiens

ADGRV1, also known as G protein-coupled receptor 98 (GPR98) or Very Large G-protein coupled receptor 1 (VLGR1), is a protein that in humans is encoded by the GPR98 gene. Several alternatively spliced transcripts have been described.

<span class="mw-page-title-main">LPAR1</span> Protein

Lysophosphatidic acid receptor 1 also known as LPA1 is a protein that in humans is encoded by the LPAR1 gene. LPA1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

<span class="mw-page-title-main">LPAR4</span> Protein-coding gene in the species Homo sapiens

Lysophosphatidic acid receptor 4 also known as LPA4 is a protein that in humans is encoded by the LPAR4 gene. LPA4 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

<span class="mw-page-title-main">P2RY11</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.

<span class="mw-page-title-main">LPAR2</span> Protein-coding gene in the species Homo sapiens

Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene. LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

<span class="mw-page-title-main">P2RY14</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 14 is a protein that in humans is encoded by the P2RY14 gene.

<span class="mw-page-title-main">GPR45</span> Protein-coding gene in humans

Probable G-protein coupled receptor 45 is a protein that in humans is encoded by the GPR45 gene.

<span class="mw-page-title-main">P2RY10</span> Protein-coding gene in the species Homo sapiens

Putative P2Y purinoceptor 10 is a protein that, in humans, is encoded by the P2RY10 gene.

<span class="mw-page-title-main">P2RY13</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 13 is a protein that in humans is encoded by the P2RY13 gene.

<span class="mw-page-title-main">LPAR5</span> Protein-coding gene in the species Homo sapiens

Lysophosphatidic acid receptor 5 also known as LPA5 is a protein that in humans is encoded by the LPAR5 gene. LPA5 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

<span class="mw-page-title-main">GPR63</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.

<span class="mw-page-title-main">P2RY8</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.

<span class="mw-page-title-main">LPAR3</span> Protein-coding gene in the species Homo sapiens

Lysophosphatidic acid receptor 3 also known as LPA3 is a protein that in humans is encoded by the LPAR3 gene. LPA3 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

<span class="mw-page-title-main">KDM5A</span> Protein-coding gene in the species Homo sapiens

Lysine-specific demethylase 5A is an enzyme that in humans is encoded by the KDM5A gene.

<span class="mw-page-title-main">TRAP1</span> Protein-coding gene in the species Homo sapiens

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.

<span class="mw-page-title-main">LIPH (gene)</span> Protein-coding gene in the species Homo sapiens

Lipase member H is an enzyme that in humans is encoded by the LIPH gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000139679 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033446 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (June 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492 (1): 127–138. doi:10.1016/S0167-4781(00)00094-4. PMID   11004484.
  6. Ralevic V, Burnstock G (September 1998). "Receptors for purines and pyrimidines". Pharmacological Reviews. 50 (3): 413–492. PMID   9755289.
  7. Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, et al. (June 2009). "Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6". The Journal of Biological Chemistry. 284 (26): 17731–17741. doi: 10.1074/jbc.M808506200 . PMC   2719412 . PMID   19386608.
  8. 1 2 "Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5".
  9. 1 2 Pasternack SM, von Kügelgen I, Al Aboud K, Lee YA, Rüschendorf F, Voss K, et al. (March 2008). "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth". Nature Genetics. 40 (3): 329–334. doi:10.1038/ng.84. PMID   18297070. S2CID   20241237.
  10. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, et al. (January 2010). "LPA receptors: subtypes and biological actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID   20055701.
  11. "Hypotrichosis simplex - About the Disease - Genetic and Rare Diseases Information Center". rarediseases.info.nih.gov. Retrieved 2023-05-06.
  12. Gandolfi B, Alhaddad H, Affolter VK, Brockman J, Haggstrom J, Joslin SE, et al. (2013-06-27). "To the Root of the Curl: A Signature of a Recent Selective Sweep Identifies a Mutation That Defines the Cornish Rex Cat Breed". PLOS ONE. 8 (6): e67105. Bibcode:2013PLoSO...867105G. doi: 10.1371/journal.pone.0067105 . PMC   3694948 . PMID   23826204.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.