TAS2R45

TAS2R45
Identifiers
Aliases	TAS2R45 , GPR59, T2R45, ZG24P, taste 2 receptor member 45
External IDs	OMIM: 613967 GeneCards: TAS2R45
Gene location (Human)
Chr.	Chromosome 12 (human)
End	11,184,006 bp
Gene ontology
Molecular function	• G-protein coupled receptor activity ; • signal transducer activity ; • bitter taste receptor activity ;
Cellular component	• integral component of membrane ; • cell membrane ; • membrane ;
Biological process	• detection of chemical stimulus involved in sensory perception of bitter taste ; • signal transduction ; • response to stimulus ; • sensory perception of taste ; • G-protein coupled receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	259291
	n/a
	ENSG00000261936
	n/a
	P59539
	n/a
	NM_176886
	n/a
	NP_795367
	n/a
	Wikidata
View/Edit Human

Last updated December 04, 2020

Taste receptor type 2 member 45 is a protein that in humans is encoded by the TAS2R45 gene.^[2]^[3]

Related Research Articles

Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the TAS2R1 gene. It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane helix bundles and short N-terminus loop. Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the perception of bitter taste in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues.

Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.

Taste receptor type 2 member 4 is a protein that in humans is encoded by the TAS2R4 gene.

Taste receptor type 2 member 8 is a protein that in humans is encoded by the TAS2R8 gene.

Taste receptor type 2 member 9 is a protein that in humans is encoded by the TAS2R9 gene.

Taste receptor type 2 member 10 is a protein that in humans is encoded by the TAS2R10 gene.

Taste receptor type 2 member 13 is a protein that in humans is encoded by the TAS2R13 gene.

Taste receptor type 2 member 14 is a protein that in humans is encoded by the TAS2R14 gene.

Taste receptor type 2 member 5 is a protein that in humans is encoded by the TAS2R5 gene.

Taste receptor type 2 member 7 is a protein that in humans is encoded by the TAS2R7 gene.

Taste receptor type 2 member 39 is a protein that in humans is encoded by the TAS2R39 gene.

Taste receptor type 2 member 40 is a protein that in humans is encoded by the TAS2R40 gene.

Taste receptor type 2 member 41 is a protein that in humans is encoded by the TAS2R41 gene.

Taste receptor type 2 member 43 is a protein that in humans is encoded by the TAS2R43 gene.

Taste receptor type 2 member 46 is a protein that in humans is encoded by the TAS2R46 gene.

Taste receptor type 2 member 30 is a protein that in humans is encoded by the TAS2R30 gene.

Taste receptor type 2 member 19 is a protein that in humans is encoded by the TAS2R19 gene. It seems to be involved in the perception of salt and bitter tastes.

Taste receptor type 2 member 20 is a protein that in humans is encoded by the TAS2R20 gene.

Taste receptor type 2 member 50 is a protein that in humans is encoded by the TAS2R50 gene.

Taste receptor type 2 member 60 is a protein that in humans is encoded by the TAS2R60 gene.

References

↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (Oct 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. S2CID 20426192.
↑ "Entrez Gene: TAS2R45 taste receptor, type 2, member 45".

Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi: 10.1074/jbc.R100054200 . PMID 11696554.
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982. S2CID 37807140.
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520. S2CID 718601.
Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719 . PMID 15744053.

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[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12379855-2] Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (Oct 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. S2CID 20426192.

[entrez-3] "Entrez Gene: TAS2R45 taste receptor, type 2, member 45".

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[2]

[3]

TAS2R45

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References

Further reading