MAS1 oncogene

Last updated
MAS1 oncogene
Identifiers
SymbolMAS1
NCBI gene 4142
HGNC 6899
OMIM 165180
RefSeq NM_002377
UniProt P04201
Other data
Locus Chr. 6 q24-q27
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Structures Swiss-model
Domains InterPro
MAS1 oncogene-like
Identifiers
SymbolMAS1L
NCBI gene 116511
HGNC 13961
OMIM 607235
RefSeq NM_052967
UniProt P35410
Other data
Locus Chr. 6 p21
Search for
Structures Swiss-model
Domains InterPro

The MAS1 oncogene (MAS receptor) is a G protein-coupled receptor [1] [2] which binds the angiotensin II metabolite angiotensin (1-7). [3] [4] The MAS1 receptor, when activated by binding angiotensin-(1-7), opposes many of the effects of the angiotensin II receptor. Hence, MAS1 receptor agonists have similar therapeutic effects to angiotensin II receptor antagonists, including lowering of blood pressure. [5]

Related Research Articles

<span class="mw-page-title-main">G protein-coupled receptor</span> Class of cell surface receptors coupled to G-protein-associated intracellular signaling

G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. They are coupled with G proteins. They pass through the cell membrane seven times in the form of six loops of amino acid residues, which is why they are sometimes referred to as seven-transmembrane receptors. Ligands can bind either to the extracellular N-terminus and loops or to the binding site within transmembrane helices. They are all activated by agonists, although a spontaneous auto-activation of an empty receptor has also been observed.

<span class="mw-page-title-main">Angiotensin</span> Group of peptide hormones in mammals

Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure. It is part of the renin–angiotensin system, which regulates blood pressure. Angiotensin also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys.

<span class="mw-page-title-main">Angiotensin-converting enzyme 2</span> Exopeptidase enzyme that acts on angiotensin I and II

Angiotensin-converting enzyme 2 (ACE2) is an enzyme that can be found either attached to the membrane of cells (mACE2) in the intestines, kidney, testis, gallbladder, and heart or in a soluble form (sACE2). Both membrane bound and soluble ACE2 are integral parts of the renin–angiotensin–aldosterone system (RAAS) that exists to keep the body's blood pressure in check. mACE2 is cleaved by the enzyme ADAM17 that releases its extracellular domain, creating soluble ACE2 (sACE2). ACE2 enzyme activity opposes the classical arm of the RAAS by lowering blood pressure through catalyzing the hydrolysis of angiotensin II into angiotensin (1–7). Angiotensin (1-7) in turns binds to MasR receptors creating localized vasodilation and hence decreasing blood pressure. This decrease in blood pressure makes the entire process a promising drug target for treating cardiovascular diseases.

The bradykinin receptor family is a group of G-protein coupled receptors whose principal ligand is the protein bradykinin.

Neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin. Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled. Numerous crystal structures have been reported for the neurotensin receptor 1 (NTS1). The third receptor has a single transmembrane domain and is encoded by the SORT1 gene.

<span class="mw-page-title-main">MAS1</span> Protein-coding gene in the species Homo sapiens

MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor, is a protein that in humans is encoded by the MAS1 gene. The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.

<span class="mw-page-title-main">Angiotensin II receptor type 1</span> Protein-coding gene in the species Homo sapiens

Angiotensin II receptor type 1(AT1) is a Gq/11-coupled G protein-coupled receptor (GPCR) and the best characterized angiotensin receptor. It is encoded in humans by the AGTR1 gene. AT1 has vasopressor effects and regulates aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Angiotensin II receptor blockers are drugs indicated for hypertension, diabetic nephropathy and congestive heart failure.

Bradykinin receptor B<sub>2</sub> Protein-coding gene in the species Homo sapiens

Bradykinin receptor B2 is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans.

<span class="mw-page-title-main">Angiotensin II receptor type 2</span> Protein-coding gene in humans

Angiotensin II receptor type 2, also known as the AT2 receptor is a protein that in humans is encoded by the AGTR2 gene.

<span class="mw-page-title-main">Melanocortin 3 receptor</span> Mammalian protein found in Homo sapiens

Melanocortin 3 receptor (MC3R) is a protein that in humans is encoded by the MC3R gene.

<span class="mw-page-title-main">Hydroxycarboxylic acid receptor 3</span> Protein-coding gene in the species Homo sapiens

Hydroxycarboxylic acid receptor 3 (HCA3), also known as niacin receptor 2 (NIACR2) and GPR109B, is a protein which in humans is encoded by the HCAR3 gene. HCA3, like the other hydroxycarboxylic acid receptors HCA1 and HCA2, is a Gi/o-coupled G protein-coupled receptor (GPCR). The primary endogenous agonists of HCA3 are 3-hydroxyoctanoic acid and kynurenic acid. HCA3 is also a low-affinity biomolecular target for niacin (aka nicotinic acid).

<span class="mw-page-title-main">Relaxin/insulin-like family peptide receptor 3</span> Protein-coding gene in the species Homo sapiens

Relaxin/insulin-like family peptide receptor 3, also known as RXFP3, is a human G-protein coupled receptor.

<span class="mw-page-title-main">MRGPRD</span> Protein-coding gene in the species Homo sapiens

Mas-related G-protein coupled receptor member D is a protein that in humans is encoded by the MRGPRD gene.

<span class="mw-page-title-main">MRGPRX2</span> Protein-coding gene in the species Homo sapiens

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene. It is most abundant on cutaneous mast cells.

<span class="mw-page-title-main">MAS1L</span> Protein-coding gene in the species Homo sapiens

Mas-related G-protein coupled receptor MRG is a protein that in humans is encoded by the MAS1L gene.

<span class="mw-page-title-main">MRGPRX4</span> Protein-coding gene in the species Homo sapiens

Mas-related G-protein coupled receptor member X4 is a protein that in humans is encoded by the MRGPRX4 gene.

<span class="mw-page-title-main">Rhodopsin-like receptors</span> Family of proteins

Rhodopsin-like receptors are a family of proteins that comprise the largest group of G protein-coupled receptors.

<span class="mw-page-title-main">Angiotensin (1-7)</span> Chemical compound

Angiotensin (1-7) is an active heptapeptide of the renin–angiotensin system (RAS).

<span class="mw-page-title-main">L-163,491</span> Chemical compound

L-163,491 is an experimental drug which acts as a partial agonist of angiotensin II receptor type 1, and with lower affinity as an agonist of angiotensin II receptor type 2, mimicking the action of angiotensin II. Its practical applications to date have been limited to scientific research into the function of the angiotensin receptor system, but it has been suggested as a potential therapeutic agent for the treatment of inflammation of the lungs associated with certain viral diseases such as COVID-19.

<span class="mw-page-title-main">Alamandine</span> Pharmacology of a New Angiotensin Peptide

Alamandine is a member of renin-angiotensin system (RAS) with cardiovascular functions that are protective and opposing to the classical axis. Alamandine is a product of ACE2-dependent catalytic hydrolysis of angiotensin A and can also be generated by decarboxylation of aspartic acid residue of Ang-(1-7). Ang A is Ala1-Ang II. In mononuclear leucocytes, angiotensin II is converted to Ang A by decarboxylation of aspartic acid. Ang A is detected in human circulation and was shown to be higher in individuals with end-stage renal disease.

References

  1. Nunes-Silva A, Rocha GC, Magalhaes DM, Vaz LN, Salviano de Faria MH, Simoes e Silva AC (November 2017). "Physical Exercise and ACE2-Angiotensin-(1-7)-Mas Receptor Axis of the Renin Angiotensin System". Protein and Peptide Letters. Bentham Science Publishers Ltd. 24 (9): 809–816. doi:10.2174/0929866524666170728151401. PMID   28758593. (2) a counter-regulatory or vasodilator pathway comprising angiotensin-converting enzyme 2 (ACE2), Angiotensin-(1-7) [Ang-(1-7)] and Mas receptor, which is involved in vasodilation, antiproliferation, anti-hypertrophy, cardioprotective and renoprotective actions.
  2. Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (June 1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell. 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID   3708691. S2CID   29886272.
  3. Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, et al. (July 2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8258–63. Bibcode:2003PNAS..100.8258S. doi: 10.1073/pnas.1432869100 . PMC   166216 . PMID   12829792.
  4. Santos RA, Ferreira AJ (March 2007). "Angiotensin-(1-7) and the renin-angiotensin system". Current Opinion in Nephrology and Hypertension. 16 (2): 122–8. doi:10.1097/MNH.0b013e328031f362. PMID   17293687. S2CID   32812104.
  5. Santos RA, Ferreira AJ (2006). "Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist". Cardiovascular Drug Reviews. 24 (3–4): 239–46. doi: 10.1111/j.1527-3466.2006.00239.x . PMID   17214600.