TAS2R13

TAS2R13
Identifiers
Aliases	TAS2R13 , T2R13, TRB3, taste 2 receptor member 13
External IDs	OMIM: 604792 MGI: 2681259 HomoloGene: 41542 GeneCards: TAS2R13
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.2 Start 10,907,926 bp [1] End 10,909,562 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 G1|6 64.03 cM Start 132,700,090 bp [2] End 132,701,007 bp [2]
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • taste receptor activity • bitter taste receptor activity Cellular component • cell membrane • membrane • integral component of membrane Biological process • positive regulation of cytokinesis • detection of chemical stimulus involved in sensory perception of bitter taste • signal transduction • response to stimulus • sensory perception of taste • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50838	387349
Ensembl	ENSG00000212128 ENSG00000277254 ENSG00000273457	ENSMUSG00000071150
UniProt	Q9NYV9	Q7M720
RefSeq (mRNA)	NM_023920	NM_207024
RefSeq (protein)	NP_076409	NP_996907
Location (UCSC)	Chr 12: 10.91 – 10.91 Mb	Chr 6: 132.7 – 132.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Taste receptor type 2 member 13 is a protein that in humans is encoded by the TAS2R13 gene. ^{[5] [6] [7]}

Function

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. ^[7]

See also

• Taste receptor

References

1. ENSG00000277254, ENSG00000273457 GRCh38: Ensembl release 89: ENSG00000212128, ENSG00000277254, ENSG00000273457 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071150 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID   10761934. S2CID   14604586.
6. Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. doi:10.1038/35007072. PMID   10766242. S2CID   4336913.
7. "Entrez Gene: TAS2R13 taste receptor, type 2, member 13".

Further reading

• Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10. doi: 10.1016/S0896-6273(00)81054-5 . PMID   10774719.
• Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi: 10.1074/jbc.R100054200 . PMID   11696554.
• Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID   12139982. S2CID   37807140.
• Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID   10761935. S2CID   7293493.
• Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID   12581520. S2CID   718601.
• Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi: 10.1093/molbev/msi027 . PMID   15496549.
• Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC   1449719 . PMID   15744053.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.