GPR146 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | GPR146 , PGR8, G protein-coupled receptor 146 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 1933113; HomoloGene: 36472; GeneCards: GPR146; OMA:GPR146 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Probable G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene. [5] The receptor has been shown to bind a gut-derived hormone called cholesin/C17orf50 in response to dietary cholesterol. [6] . Consistent with this interaction, murine genetic disruption of GPR146 lowers serum cholesterol and reduces atherosclerotic aortic lesions. [7] It has also been identified as a possible receptor for C-peptide. [8]
Glucagon-like peptide-2 receptor (GLP-2R) is a protein that in human is encoded by the GLP2R gene located on chromosome 17.
Parathyroid hormone/parathyroid hormone-related peptide receptor, also known as parathyroid hormone 1 receptor (PTH1R), is a protein that in humans is encoded by the PTH1R gene. PTH1R functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP), also called parathyroid hormone-like hormone (PTHLH).
Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein; it is a receptor for calcitonin gene-related peptide.
Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene. It is a member of the adhesion-GPCR family of receptors.
Corticotropin-releasing hormone receptor 2 (CRHR2) is a protein, also known by the IUPHAR-recommended name CRF2, that is encoded by the CRHR2 gene and occurs on the surfaces of some mammalian cells. CRF2 receptors are type 2 G protein-coupled receptors for corticotropin-releasing hormone (CRH) that are resident in the plasma membranes of hormone-sensitive cells. CRH, a peptide of 41 amino acids synthesized in the hypothalamus, is the principal neuroregulator of the hypothalamic-pituitary-adrenal axis, signaling via guanine nucleotide-binding proteins (G proteins) and downstream effectors such as adenylate cyclase. The CRF2 receptor is a multi-pass membrane protein with a transmembrane domain composed of seven helices arranged in a V-shape. CRF2 receptors are activated by two structurally similar peptides, urocortin II, and urocortin III, as well as CRH.
Probable G-protein coupled receptor 19 is a protein that in humans is encoded by the GPR19 gene. GPR19 has been proposed as the receptor for the peptide hormone adropin.
Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene. GPR37 is primarily found in the central nervous system (CNS), with significant expression observed in various CNS regions including the amygdala, basal ganglia, substantia nigra, hippocampus, frontal cortex, and hypothalamus, particularly noteworthy is its exceptionally elevated expression in the spinal cord.
Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene.
Vasoactive intestinal peptide receptor 2 also known as VPAC2, is a G-protein coupled receptor that in humans is encoded by the VIPR2 gene.
Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene.
Relaxin/insulin-like family peptide receptor 3, also known as RXFP3, is a human G-protein coupled receptor.
GPR113 is a gene that encodes the Probable G-protein coupled receptor 113 protein.
Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene. GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.
Probable G-protein coupled receptor 150 is a protein that in humans is encoded by the GPR150 gene.
Probable G-protein coupled receptor 153 is a protein that in humans is encoded by the GPR153 gene.
Probable G-protein coupled receptor 152 is a protein that in humans is encoded by the GPR152 gene.
Probable G-protein coupled receptor 151 is a protein that in humans is encoded by the GPR151 gene.
Pancreatic polypeptide receptor 1, also known as Neuropeptide Y receptor type 4, is a protein that in humans is encoded by the PPYR1 gene.
Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.
GPR182 is a human gene which is an orphan G-protein coupled receptor.
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