GPR146

GPR146
Identifiers
Aliases	GPR146 , PGR8, G protein-coupled receptor 146
External IDs	MGI: 1933113; HomoloGene: 36472; GeneCards: GPR146; OMA:GPR146 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p22.3 Start 1,044,546 bp [1] End 1,059,261 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G2 Start 139,377,697 bp [2] End 139,396,415 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in subcutaneous adipose tissue abdominal fat apex of heart gastric mucosa right lung tibial nerve blood left ventricle body of stomach upper lobe of left lung Top expressed in interventricular septum retinal pigment epithelium muscle of thigh myocardium of ventricle left lobe of liver right lung triceps brachii muscle right kidney right lung lobe stroma of bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity G protein-coupled receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115330 80290 Ensembl ENSG00000164849 ENSMUSG00000044197 UniProt Q96CH1 Q99LE2 RefSeq (mRNA) NM_001303473 NM_001303474 NM_138445 NM_001038703 NM_030258 RefSeq (protein) NP_001290402 NP_001290403 NP_612454 NP_001033792 NP_084534 NP_001349135 Location (UCSC) Chr 7: 1.04 – 1.06 Mb Chr 5: 139.38 – 139.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene. ^[5] The receptor has been shown to bind cholesin/C7orf50, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption. In response to cholesin binding, GPR146 signaling inhibit cholesterol synthesis. ^[6] Consistent with this interaction, murine genetic disruption of GPR146 lowers serum cholesterol and reduces atherosclerotic aortic lesions. ^[7] GPR146 has also been identified as a possible receptor for C-peptide. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000164849 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044197 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR146 G protein-coupled receptor 146".
6. Hu X, Chen F, Jia L, Long A, Peng Y, Li X; et al. (2024). "A gut-derived hormone regulates cholesterol metabolism" . Cell. 187 (7): 1685-1700.e18. doi: 10.1016/j.cell.2024.02.024 . PMID   38503280.
7. Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F; et al. (2019). "GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis". Cell. 179 (6): 1276-1288.e14. doi:10.1016/j.cell.2019.10.034. PMC   6889877 . PMID   31778654. Archived from the original on September 27, 2024.
8. Yosten GL, Kolar GR, Redlinger LJ, Samson WK (11 July 2013). "Evidence for an interaction between proinsulin C-peptide and GPR146". The Journal of Endocrinology. 218 (2): B1-8. doi: 10.1530/JOE-13-0203 . PMID   23759446.

Further reading

• Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi: 10.1073/pnas.0230374100 . PMC   153653 . PMID   12679517.
• Gloriam DE, Schiöth HB, Fredriksson R (Apr 2005). "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship". Biochimica et Biophysica Acta (BBA) - General Subjects. 1722 (3): 235–46. doi:10.1016/j.bbagen.2004.12.001. PMID   15777626.