Taste receptor

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Taste receptor
1402 The Tongue.jpg
Taste receptors of the tongue are present in the taste buds of papillae.
Identifiers
FMA 84662
Anatomical terminology

A taste receptor or tastant is a type of cellular receptor which facilitates the sensation of taste. When food or other substances enter the mouth, molecules interact with saliva and are bound to taste receptors in the oral cavity and other locations. Molecules which give a sensation of taste are considered "sapid". [1]

Contents

Vertebrate taste receptors are divided into two families:[ citation needed ]

Visual, olfactive, "sapictive" (the perception of tastes), trigeminal (hot, cool), mechanical, all contribute to the perception of taste. Of these, transient receptor potential cation channel subfamily V member 1 (TRPV1) vanilloid receptors are responsible for the perception of heat from some molecules such as capsaicin, and a CMR1 receptor is responsible for the perception of cold from molecules such as menthol, eucalyptol, and icilin. [1]

Tissue distribution

The gustatory system consists of taste receptor cells in taste buds. Taste buds, in turn, are contained in structures called papillae. There are three types of papillae involved in taste: fungiform papillae, foliate papillae, and circumvallate papillae. (The fourth type - filiform papillae do not contain taste buds). Beyond the papillae, taste receptors are also in the palate and early parts of the digestive system like the larynx and upper esophagus. There are three cranial nerves that innervate the tongue; the vagus nerve, glossopharyngeal nerve, and the facial nerve. The glossopharyngeal nerve and the chorda tympani branch of the facial nerve innervate the TAS1R and TAS2R taste receptors. Next to the taste receptors in on the tongue, the gut epithelium is also equipped with a subtle chemosensory system that communicates the sensory information to several effector systems involved in the regulation of appetite, immune responses, and gastrointestinal motility [5]

In 2010, researchers found bitter receptors in lung tissue, which cause airways to relax when a bitter substance is encountered. They believe this mechanism is evolutionarily adaptive because it helps clear lung infections, but could also be exploited to treat asthma and chronic obstructive pulmonary disease. [6]

The sweet taste receptor (T1R2/T1R3) can be found in various extra-oral organs throughout the human body such as the brain, heart, kidney, bladder, nasal respiratory epithelium and more. In most of the organs, the receptor function is unclear. [7] The sweet taste receptor found in the gut and in the pancreas was found to play an important role in the metabolic regulation of the gut carbohydrate-sensing process and in insulin secretion. [8] This receptor is also found in the bladder, suggesting that consumption of artificial sweeteners which activates this receptor might cause excessive bladder contraction. [9]

Function

Taste helps to identify toxins, maintain nutrition, and regulate appetite, immune responses, and gastrointestinal motility. [5] Five basic tastes are recognized today: salty, sweet, bitter, sour, and umami. Salty and sour taste sensations are both detected through ion channels. Sweet, bitter, and umami tastes, however, are detected by way of G protein-coupled taste receptors. [10]

In addition, some agents can function as taste modifiers, as miraculin or curculin for sweet or sterubin to mask bitter.

Mechanism of action

The standard bitter, sweet, or umami taste receptor is a G protein-coupled receptor with seven transmembrane domains. Ligand binding at the taste receptors activate second messenger cascades to depolarize the taste cell. Gustducin is the most common taste Gα subunit, having a major role in TAS2R bitter taste reception. Gustducin is a homologue for transducin, a G-protein involved in vision transduction. [11] Additionally, taste receptors share the use of the TRPM5 ion channel, as well as a phospholipase PLCβ2. [12]

Savory or glutamates (Umami)

The TAS1R1+TAS1R3 heterodimer receptor functions as an umami receptor, responding to L-amino acid binding, especially L-glutamate. [2] The umami taste is most frequently associated with the food additive monosodium glutamate (MSG) and can be enhanced through the binding of inosine monophosphate (IMP) and guanosine monophosphate (GMP) molecules. [13] [14] TAS1R1+3 expressing cells are found mostly in the fungiform papillae at the tip and edges of the tongue and palate taste receptor cells in the roof of the mouth. [2] These cells are shown to synapse upon the chorda tympani nerves to send their signals to the brain, although some activation of the glossopharyngeal nerve has been found. [13] [15]

Alternative candidate umami taste receptors include splice variants of metabotropic glutamate receptors, mGluR4 and mGluR1, and the NMDA receptor. [10] [16] [17] [18]

During the evolution of songbirds, the umami taste receptor has undergone structural modifications in the ligand binding site, enabling these birds to sense the sweet taste by this receptor. [19]

Sweet

The diagram above depicts the signal transduction pathway of the sweet taste. Object A is a taste bud, object B is one taste cell of the taste bud, and object C is the neuron attached to the taste cell. I. Part I shows the reception of a molecule. 1. Sugar, the first messenger, binds to a protein receptor on the cell membrane. II. Part II shows the transduction of the relay molecules. 2. G Protein-coupled receptors, second messengers, are activated. 3. G Proteins activate adenylate cyclase, an enzyme, which increases the cAMP concentration. Depolarization occurs. 4. The energy, from step 3, is given to activate the K+, potassium, protein channels.III. Part III shows the response of the taste cell. 5. Ca+, calcium, protein channels is activated.6. The increased Ca+ concentration activates neurotransmitter vesicles. 7. The neuron connected to the taste bud is stimulated by the neurotransmitters. Signal Transaction of the Sweet Taste.svg
The diagram above depicts the signal transduction pathway of the sweet taste. Object A is a taste bud, object B is one taste cell of the taste bud, and object C is the neuron attached to the taste cell. I. Part I shows the reception of a molecule. 1. Sugar, the first messenger, binds to a protein receptor on the cell membrane. II. Part II shows the transduction of the relay molecules. 2. G Protein-coupled receptors, second messengers, are activated. 3. G Proteins activate adenylate cyclase, an enzyme, which increases the cAMP concentration. Depolarization occurs. 4. The energy, from step 3, is given to activate the K+, potassium, protein channels.III. Part III shows the response of the taste cell. 5. Ca+, calcium, protein channels is activated.6. The increased Ca+ concentration activates neurotransmitter vesicles. 7. The neuron connected to the taste bud is stimulated by the neurotransmitters.

The TAS1R2+TAS1R3 heterodimer receptor functions as the sweet receptor by binding to a wide variety of sugars and sugar substitutes. [2] [20] TAS1R2+3 expressing cells are found in circumvallate papillae and foliate papillae near the back of the tongue and palate taste receptor cells in the roof of the mouth. [2] These cells are shown to synapse upon the chorda tympani and glossopharyngeal nerves to send their signals to the brain. [10] [15] The TAS1R3 homodimer also functions as a sweet receptor in much the same way as TAS1R2+3 but has decreased sensitivity to sweet substances. Natural sugars are more easily detected by the TAS1R3 receptor than sugar substitutes. This may help explain why sugar and artificial sweeteners have different tastes. [21] Genetic polymorphisms in TAS1R3 partly explain the difference in sweet taste perception and sugar consumption between people of African American ancestry and people of European and Asian ancestries. [22] [23]

Sensing of the sweet taste has changed throughout the evolution of different animals. Mammals sense the sweet taste by transferring the signal through the heterodimer T1R2/T1R3, the sweet taste receptor. In birds, however, the T1R2 monomer does not exist and they sense the sweet taste through the heterodimer T1R1/T1R3, the umami taste receptor, which has gone through modifications during their evolution. A recently conducted study showed that along the evolution stages of songbirds, there was a decrease in the ability to sense the umami taste, and an increase in the ability to sense the sweet taste, whereas the primordial songbird parent could only sense the umami taste. Researchers found a possible explanation for this phenomenon to be a structural change in the ligand binding site of the umami receptor between the sweet taste sensing and non-sensing songbirds. It is assumed that a mutation in the binding site occurred over time, which allowed them to sense the sweet taste through the umami taste receptor. [19]

Bitter

The TAS2R proteins (InterPro :  IPR007960 ) function as bitter taste receptors. [24] There are 43 human TAS2R genes, each of which (excluding the five pseudogenes) lacks introns and codes for a GPCR protein. [10] These proteins, as opposed to TAS1R proteins, have short extracellular domains and are located in circumvallate papillae, palate, foliate papillae, and epiglottis taste buds, with reduced expression in fungiform papillae. [3] [10] Though it is certain that multiple TAS2Rs are expressed in one taste receptor cell, it is still debated whether mammals can distinguish between the tastes of different bitter ligands. [3] [10] Some overlap must occur, however, as there are far more bitter compounds than there are TAS2R genes. Common bitter ligands include cycloheximide, denatonium, PROP (6-n-propyl-2-thiouracil), PTC (phenylthiocarbamide), and β-glucopyranosides. [10]

Signal transduction of bitter stimuli is accomplished via the α-subunit of gustducin. This G protein subunit activates a taste phosphodiesterase and decreases cyclic nucleotide levels. Further steps in the transduction pathway are still unknown. The βγ-subunit of gustducin also mediates taste by activating IP3 (inositol triphosphate) and DAG (diglyceride). These second messengers may open gated ion channels or may cause release of internal calcium. [25] Though all TAS2Rs are located in gustducin-containing cells, knockout of gustducin does not completely abolish sensitivity to bitter compounds, suggesting a redundant mechanism for bitter tasting [12] (unsurprising given that a bitter taste generally signals the presence of a toxin). [12] One proposed mechanism for gustducin-independent bitter tasting is via ion channel interaction by specific bitter ligands, similar to the ion channel interaction which occurs in the tasting of sour and salty stimuli. [10]

One of the best-researched TAS2R proteins is TAS2R38, which contributes to the tasting of both PROP and PTC. It is the first taste receptor whose polymorphisms are shown to be responsible for differences in taste perception. Current studies are focused on determining other such taste phenotype-determining polymorphisms. [10] More recent studies show that genetic polymorphisms in other bitter taste receptor genes influence bitter taste perception of caffeine, quinine and denatonium benzoate. [26]

The diagram depicted above shows the signal transduction pathway of the bitter taste. Bitter taste has many different receptors and signal transduction pathways. Bitter indicates poison to animals. It is most similar to sweet. Object A is a taste bud, object B is one taste cell, and object C is a neuron attached to object B. I. Part I is the reception of a molecule.1. A bitter substance such as quinine, is consumed and binds to G Protein-coupled receptors.II. Part II is the transduction pathway 2. Gustducin, a G protein second messenger, is activated. 3. Phosphodiesterase, an enzyme, is then activated. 4. Cyclic nucleotide, cNMP, is used, lowering the concentration 5. Channels such as the K+, potassium, channels, close.III. Part III is the response of the taste cell. 6. This leads to increased levels of Ca+. 7. The neurotransmitters are activated. 8. The signal is sent to the neuron. Signal Transaction of Taste; Bitter.svg
The diagram depicted above shows the signal transduction pathway of the bitter taste. Bitter taste has many different receptors and signal transduction pathways. Bitter indicates poison to animals. It is most similar to sweet. Object A is a taste bud, object B is one taste cell, and object C is a neuron attached to object B. I. Part I is the reception of a molecule.1. A bitter substance such as quinine, is consumed and binds to G Protein-coupled receptors.II. Part II is the transduction pathway 2. Gustducin, a G protein second messenger, is activated. 3. Phosphodiesterase, an enzyme, is then activated. 4. Cyclic nucleotide, cNMP, is used, lowering the concentration 5. Channels such as the K+, potassium, channels, close.III. Part III is the response of the taste cell. 6. This leads to increased levels of Ca+. 7. The neurotransmitters are activated. 8. The signal is sent to the neuron.

It has been demonstrated that bitterness receptors (TAS2R) play an important role in an innate immune system of airway (nose and sinuses) ciliated epithelium tissues. [27] This innate immune system adds an "active fortress" [28] to the physical Immune system surface barrier. This fixed immune system is activated by the binding of ligands to specific receptors. These natural ligands are bacterial markers, for TAS2R38 example: acyl-homoserine lactones [29] or quinolones [30] produced by Pseudomonas aeruginosa. To defend against predators, some plants have produced mimic bacterial markers substances. These plant mimes are interpreted by the tongue, and the brain, as being bitterness. The fixed immune system receptors are identical to the bitter taste receptors, TAS2R. Bitterness substances are agonist of TAS2R fixed immune system. [27] The innate immune system uses nitric oxide and defensins which are capable of destroying bacteria, and also viruses. [31] [32] These fixed innate immune systems (Active Fortresses) are known in other epithelial tissues than upper airway (nose, sinuses, trachea, bronchi), for example: breast (mammary epithelial cells), gut and also human skin (keratinocytes) [33] Bitter molecules, their associated bitter taste receptors, and the sequences and homology models of bitter taste receptors, are available via BitterDB.

Sour

Historically it was thought that the sour taste was produced solely when free hydrogen ions (H+) directly depolarised taste receptors. However, specific receptors for sour taste with other methods of action are now being proposed. The HCN channels were such a proposal; as they are cyclic nucleotide-gated channels. The two ion channels now suggested to contribute to sour taste are ASIC2 and TASK-1.

The diagram depicts the signal transduction pathway of the sour or salty taste. Object A is a taste bud, object B is a taste receptor cell within object A, and object C is the neuron attached to object B. I. Part I is the reception of hydrogen ions or sodium ions. 1. If the taste is sour, H+ ions, from an acidic substances, pass through their specific ion channel. Some can go through the Na+ channels. If the taste is salty Na+, sodium, molecules pass through the Na+ channels. Depolarization takes place II. Part II is the transduction pathway of the relay molecules.2. Cation, such as K+, channels are opened. III. Part III is the response of the cell. 3. An influx of Ca+ ions is activated.4. The Ca+ activates neurotransmitters. 5. A signal is sent to the neuron attached to the taste bud. Signal Transaction of Taste; Sour & Salty.svg
The diagram depicts the signal transduction pathway of the sour or salty taste. Object A is a taste bud, object B is a taste receptor cell within object A, and object C is the neuron attached to object B. I. Part I is the reception of hydrogen ions or sodium ions. 1. If the taste is sour, H+ ions, from an acidic substances, pass through their specific ion channel. Some can go through the Na+ channels. If the taste is salty Na+, sodium, molecules pass through the Na+ channels. Depolarization takes place II. Part II is the transduction pathway of the relay molecules.2. Cation, such as K+, channels are opened. III. Part III is the response of the cell. 3. An influx of Ca+ ions is activated.4. The Ca+ activates neurotransmitters. 5. A signal is sent to the neuron attached to the taste bud.

Salt

Various receptors have also been proposed for salty tastes, along with the possible taste detection of lipids, complex carbohydrates, and water. Evidence for these receptors had been unconvincing in most mammal studies. For example, the proposed ENaC receptor for sodium detection can only be shown to contribute to sodium taste in Drosophila. [10] However, proteolyzed forms of ENaC have been shown to function as a human salt taste receptor. Proteolysis is the process where a protein is cleaved. The mature form of ENaC is thought to be proteolyzed, however the characterization of which proteolyzed forms exist in which tissues is incomplete. Proteolysis of cells created to overexpress hetermulitmeric ENaC comprising alpha, beta and gamma subunits was used to identify compounds that selectively enhanced the activity of proteolyzed ENaC versus non-proteolyzed ENaC. Human sensory studies demonstrated that a compound that enhances proteolyzed ENaC functions to enhance the salty taste of table salt, or sodium chloride, confirming proteolyzed ENaC as the first human salt taste receptor. [34]

Carbonation

An enzyme connected to the sour receptor transmits information about carbonated water. [35]

Fat

A possible taste receptor for fat, CD36, has been identified. [36] CD36 has been localized to the circumvallate and foliate papillae, which are present in taste buds [37] and where lingual lipase is produced, and research has shown that the CD36 receptor binds long chain fatty acids. [38] Differences in the amount of CD36 expression in human subjects was associated with their ability to taste fats, [39] creating a case for the receptor's relationship to fat tasting. Further research into the CD36 receptor could be useful in determining the existence of a true fat-tasting receptor.

Free fatty acid receptor 4 (also termed GPR120) and to a much lesser extent free fatty acid receptor 1 (also termed GPR40) [40] have been implicated to respond to oral fat, [41] and their absence leads to reduced fat preference and reduced neuronal response to orally administered fatty acids. [42]

TRPM5 has been shown to be involved in oral fat response and identified as a possible oral fat receptor, but recent evidence presents it as primarily a downstream actor. [43] [44]

Types

Human bitter taste receptor genes are named TAS2R1 to TAS2R64, with many gaps due to non-existent genes, pseudogenes or proposed genes that have not been annotated to the most recent human genome assembly. Many bitter taste receptor genes also have confusing synonym names with several different gene names referring to the same gene. See table below for full list of human bitter taste receptor genes:

ClassGeneSynonymsAliasesLocusDescription
type 1
(sweet)		 TAS1R1 GPR701p36.23
TAS1R2 GPR711p36.23
TAS1R3 1p36
type 2
(bitter)		 TAS2R1 5p15
TAS2R27p21.3pseudogene
TAS2R3 7q31.3-q32
TAS2R4 7q31.3-q32
TAS2R5 7q31.3-q32
TAS2R67not annotated in human genome assembly
TAS2R7 12p13
TAS2R8 12p13
TAS2R9 12p13
TAS2R10 12p13
TAS2R11absent in humans
TAS2R12 TAS2R2612p13.2pseudogene
TAS2R13 12p13
TAS2R14 12p13
TAS2R1512p13.2pseudogene
TAS2R16 7q31.1-q31.3
TAS2R17absent in humans
TAS2R1812p13.2pseudogene
TAS2R19 TAS2R23, TAS2R4812p13.2
TAS2R20 TAS2R4912p13.2
TAS2R21absent in humans
TAS2R2212not annotated in human genome assembly
TAS2R24absent in humans
TAS2R25absent in humans
TAS2R27absent in humans
TAS2R28absent in humans
TAS2R29absent in humans
TAS2R30 TAS2R4712p13.2
TAS2R31 TAS2R4412p13.2
TAS2R32absent in humans
TAS2R3312not annotated in human genome assembly
TAS2R34absent in humans
TAS2R35absent in humans
TAS2R3612not annotated in human genome assembly
TAS2R3712not annotated in human genome assembly
TAS2R38 7q34
TAS2R39 7q34
TAS2R40 GPR607q34
TAS2R41 7q34
TAS2R42 12p13
TAS2R43 12p13.2
TAS2R45 GPR5912
TAS2R46 12p13.2
TAS2R50 TAS2R5112p13.2
TAS2R52absent in humans
TAS2R53absent in humans
TAS2R54absent in humans
TAS2R55absent in humans
TAS2R56absent in humans
TAS2R57absent in humans
TAS2R58absent in humans
TAS2R59absent in humans
TAS2R60 7
TAS2R62P7q34pseudogene
TAS2R63P12p13.2pseudogene
TAS2R64P12p13.2pseudogene

Loss of function

In many species, taste receptors have shown loss of functions. The evolutionary process in which taste receptors lost their function is believed to be an adaptive evolution where it is associated with feeding ecology to drive specialization and bifurcation of taste receptors. [45] Out of all the taste receptors, bitter, sweet, and umami are shown to have a correlation between inactivation of taste receptors and feeding behavior. [45] However, there are no strong evidences that support any vertebrates are missing the bitter taste receptor genes. [45]

The sweet taste receptor is one of the taste receptors where the function has been lost. In mammals, the predominant sweet taste receptor is the Type 1 taste receptor Tas1r2/Tas1r3. [46] Some mammalian species such as cats and vampire bats have shown inability to taste sweet. [46] In these species, the cause of loss of function of the sweet receptor is due to the pseudogenization of Tas1r2. [46] The pseudogenization of Tas1r2 is also observed in non-mammalian species such as chickens and tongueless Western clawed frog, and these species also show the inability to taste sweet. [46] The pseudogenization of Tas1r2 is widespread and independent in the order Carnivora. [46] Many studies have shown that the pseudogenization of taste receptors is caused by a deleterious mutation in the open reading frames (ORF). [47] In a study, it was found that in nonfeline carnivorous species, these species showed ORF-disrupting mutations of Tas1r2, and they occurred independently among the species. [46] They also showed high variance in their lineages. [46] It is hypothesized that the pseudogenization of Tas1r2 occurred through convergent evolution where carnivorous species lost their ability to taste sweet because of dietary behavior. [46]

Umami is also a taste receptor where the function has been lost in many species. The predominant umami taste receptors are Tas1r1/Tas1r3. [46] In two lineages of aquatic mammals including dolphins and sea lions, Tas1r1 has been found to be pseudogenized. [46] The pseudogenization of Tas1r1 has also been found in terrestrial, carnivorous species. [46] While the panda belongs to the order Carnivora, it is herbivorous where 99% of its diet is bamboo, and it cannot taste umami. [48] Genome sequence of the panda shows that its Tas1r1 gene is pseudogenized. [48] In a study, it was found that in all species in the order Carnivora except the panda, the open reading frame was maintained. [48] In panda, the nonsynonymous to synonymous substitutions ratio was found to be much higher than other species in order Carnivora. [48] This data correlates with fossil records date of the panda to show where panda switched from carnivore to herbivore diet. [46] Therefore, the loss of function of umami in panda is hypothesized to be caused by dietary change where the panda became less dependence on meat. [46] However, these studies do not explain herbivores such as horses and cows that have retained the Tas1r1 receptor. [48]

Overall, the loss of function of the a taste receptor is an evolutionary process that occurred due to a dietary change in species. [47]

See also

List of distinct cell types in the adult human body

Related Research Articles

<span class="mw-page-title-main">Umami</span> One of the five basic tastes

Umami, or savoriness, is one of the five basic tastes. It has been described as savory and is characteristic of broths and cooked meats.

<span class="mw-page-title-main">CD36</span> Mammalian protein found in Homo sapiens

CD36, also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded by the CD36 gene. The CD36 antigen is an integral membrane protein found on the surface of many cell types in vertebrate animals. It imports fatty acids inside cells and is a member of the class B scavenger receptor family of cell surface proteins. CD36 binds many ligands including collagen, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, oxidized low density lipoprotein, native lipoproteins, oxidized phospholipids, and long-chain fatty acids.

<span class="mw-page-title-main">Cat senses</span> Senses of Felis catus

Cat senses are adaptations that allow cats to be highly efficient predators. Cats are good at detecting movement in low light, have an acute sense of hearing and smell, and their sense of touch is enhanced by long whiskers that protrude from their heads and bodies. These senses evolved to allow cats to hunt effectively at dawn and dusk.

<span class="mw-page-title-main">TAS2R38</span> Protein-coding gene in the species Homo sapiens

Taste receptor 2 member 38 is a protein that in humans is encoded by the TAS2R38 gene. TAS2R38 is a bitter taste receptor; varying genotypes of TAS2R38 influence the ability to taste both 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC). Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the few taste receptors shown to have this function.

<span class="mw-page-title-main">Gustducin</span> G protein

Gustducin is a G protein associated with taste and the gustatory system, found in some taste receptor cells. Research on the discovery and isolation of gustducin is recent. It is known to play a large role in the transduction of bitter, sweet and umami stimuli. Its pathways are many and diverse.

<span class="mw-page-title-main">TRPM5</span> Protein-coding gene in the species Homo sapiens

Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.

<span class="mw-page-title-main">Free fatty acid receptor 1</span> Protein-coding gene in the species Homo sapiens

Free fatty acid receptor 1 (FFAR1), also known as G-protein coupled receptor 40 (GPR40), is a rhodopsin-like G-protein coupled receptor that is coded by the FFAR1 gene. This gene is located on the short arm of chromosome 19 at position 13.12. G protein-coupled receptors reside on their parent cells' surface membranes, bind any one of the specific set of ligands that they recognize, and thereby are activated to trigger certain responses in their parent cells. FFAR1 is a member of a small family of structurally and functionally related GPRs termed free fatty acid receptors (FFARs). This family includes at least three other FFARs viz., FFAR2, FFAR3, and FFAR4. FFARs bind and thereby are activated by certain fatty acids.

<span class="mw-page-title-main">TAS2R1</span> Member of the 25 known human bitter taste receptors

Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the TAS2R1 gene. It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane helix bundles and short N-terminus loop. Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the perception of bitter taste in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues.

<span class="mw-page-title-main">TAS2R10</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 10 is a protein that in humans is encoded by the TAS2R10 gene. The protein is responsible for bitter taste recognition in mammals. It serves as a defense mechanism to prevent consumption of toxic substances which often have a characteristic bitter taste.

<span class="mw-page-title-main">TAS2R14</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 14 is a protein that in humans is encoded by the TAS2R14 gene.

<span class="mw-page-title-main">TAS1R1</span> Protein

Taste receptor type 1 member 1 is a protein that in humans is encoded by the TAS1R1 gene.

<span class="mw-page-title-main">TAS1R2</span> Protein

T1R2 - Taste receptor type 1 member 2 is a protein that in humans is encoded by the TAS1R2 gene.

<span class="mw-page-title-main">TAS1R3</span> Mammalian protein found in Homo sapiens

Taste receptor type 1 member 3 is a protein that in humans is encoded by the TAS1R3 gene. The TAS1R3 gene encodes the human homolog of mouse Sac taste receptor, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners.

<span class="mw-page-title-main">TAS2R41</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 41 is a protein that in humans is encoded by the TAS2R41 gene.

<span class="mw-page-title-main">TAS2R43</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 43 is a protein that in humans is encoded by the TAS2R43 gene.

<span class="mw-page-title-main">TAS2R46</span> Protein-coding gene in the species Homo sapiens

Taste receptors for bitter substances (T2Rs/TAS2Rs) belong to the family of G-protein coupled receptors and are related to class A-like GPCRs. There are 25 known T2Rs in humans responsible for bitter taste perception.

<span class="mw-page-title-main">TAS2R20</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 20 is a protein that in humans is encoded by the TAS2R20 gene.

<span class="mw-page-title-main">TAS2R60</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 60 is a protein that in humans is encoded by the TAS2R60 gene.

<span class="mw-page-title-main">Taste</span> Sense of chemicals on the tongue

The gustatory system or sense of taste is the sensory system that is partially responsible for the perception of taste (flavor). Taste is the perception stimulated when a substance in the mouth reacts chemically with taste receptor cells located on taste buds in the oral cavity, mostly on the tongue. Taste, along with the sense of smell and trigeminal nerve stimulation, determines flavors of food and other substances. Humans have taste receptors on taste buds and other areas, including the upper surface of the tongue and the epiglottis. The gustatory cortex is responsible for the perception of taste.

<span class="mw-page-title-main">GNAT3</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein subunit that in humans is encoded by the GNAT3 gene.

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