| GPR50 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | GPR50 , H9, Mel1c, G protein-coupled receptor 50 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 300207 MGI: 1333877 HomoloGene: 3113 GeneCards: GPR50 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
G protein-coupled receptor 50 is a protein which in humans is encoded by the GPR50 gene. [5] [6] [7]
GPR50 is a member of the G protein-coupled receptor family of integral membrane proteins and is most closely related to the melatonin receptor. [6] GPR50 is able to heterodimerize with both the MT1 and MT2 melatonin receptor subtypes. While GPR50 has no effect on MT2 function, GPR50 prevented MT1 from both binding melatonin and coupling to G proteins. [8] GPR50 is the mammalian ortholog of melatonin receptor Mel1c described in non-mammalian vertebrates. [9]
Certain polymorphisms of the GPR50 gene in females are associated with increased risk of developing bipolar affective disorder, major depressive disorder, and schizophrenia. [10] Other GPR50 gene polymorphism are associated with higher fasting circulating triglyceride levels and lower circulating High-density lipoprotein levels. [11]
G protein-coupled receptor 1, also known as GPR1, is a protein that in humans is encoded by the GPR1 gene.
G-protein coupled receptor 4 is a protein that in humans is encoded by the GPR4 gene.
Neuropeptides B/W receptor 2, also known as NPBW2, is a human protein encoded by the NPBWR2 gene.
Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.
Probable G-protein coupled receptor 19 is a protein that in humans is encoded by the GPR19 gene. GPR19 has been proposed as the receptor for the peptide hormone adropin.
Probable G-protein coupled receptor 20 is a protein that in humans is encoded by the GPR20 gene.
Melatonin receptor type 1A is a protein that in humans is encoded by the MTNR1A gene.
Probable G-protein coupled receptor 52 is a protein that in humans is encoded by the GPR52 gene.
Prokineticin receptor 1, also known as PKR1, is a human protein encoded by the PROKR1 gene.
Probable G-protein coupled receptor 75 is a protein that in humans is encoded by the GPR75 gene.
Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.
Probable G-protein coupled receptor 174 is a protein that in humans is encoded by the GPR174 gene.
Integral membrane protein GPR155, also known as G protein-coupled receptor 155, is a protein that in humans is encoded by the GPR155 gene. Mutations in this gene may be associated with autism.
Probable G-protein coupled receptor 153 is a protein that in humans is encoded by the GPR153 gene.
Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.
Probable G-protein coupled receptor 83 is a protein that in humans is encoded by the GPR83 gene.
G-protein coupled receptor 139 (GPC139) is a protein that in humans is encoded by the GPR139 gene. Recent research ('21) has shown that mice with loss of GCP139 experience schizophrenia-like symptomatology that is rescued with the dopamine receptor antagonist haloperidol and the μ-opioid receptor antagonist naltrexone; as well, the recently developed, potent, and GPR139 receptor selective agonist TAK-041 is currently undergoing trials to gauge the efficacy for treating psychiatric conditions such as major depressive disorder and the negative symptoms of schizophrenia.
Melatonin receptor 1B, also known as MTNR1B, is a protein that in humans is encoded by the MTNR1B gene.
Melatonin receptor 1C, also known as MTNR1C, is a protein that is encoded by the Mtnr1c gene. This receptor has been identified in fish, amphibia, and birds, but not in humans.
