GPR149

GPR149
Identifiers
Aliases	GPR149 , IEDA, PGR10, G protein-coupled receptor 149, R35
External IDs	MGI: 2443628 HomoloGene: 16359 GeneCards: GPR149
Gene location (Human)
Chr.	Chromosome 3 (human)
End	154,430,190 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	62,512,561 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; caudate nucleus; ; putamen; ; pituitary gland; ; prefrontal cortex; ; superior frontal gyrus; ; anterior pituitary; ; hypothalamus; ; islet of Langerhans; ; substantia nigra;
	Top expressed in
	secondary oocyte; ; ventromedial nucleus; ; olfactory tubercle; ; trigeminal ganglion; ; facial motor nucleus; ; superior frontal gyrus; ; nucleus accumbens; ; lateral hypothalamus; ; ventral tegmental area; ; anterior horn of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuropeptide binding ; G protein-coupled receptor activity ; signal transducer activity ; melanin-concentrating hormone receptor activity ; peptide binding ;
Cellular component	integral component of membrane ; neuron projection ; plasma membrane ; integral component of plasma membrane ; membrane ;
Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ; negative regulation of ovulation ; G protein-coupled receptor signaling pathway ; neuropeptide signaling pathway ; preantral ovarian follicle growth ; antral ovarian follicle growth ; signal transduction ; chemical synaptic transmission ;
	Sources:Amigo / QuickGO
Orthologs
	344758
	229357
	ENSG00000174948
	ENSMUSG00000043441
	Q86SP6
	Q3UVY1
	NM_001038705
	NM_177346 ; NM_001356525
	NP_001033794
	NP_796320 ; NP_001343454
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Probable G-protein coupled receptor 149 is a protein that in humans is encoded by the GPR149 gene.^[5]^[6]

Related Research Articles

Probable G-protein coupled receptor 135 is a protein that in humans is encoded by the GPR135 gene.

Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene. It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Probable G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene. It has been identified as a possible receptor for C-peptide.

Mas-related G-protein coupled receptor member E is a protein that in humans is encoded by the MRGPRE gene.

Integral membrane protein GPR155, also known as G protein-coupled receptor 155, is a protein that in humans is encoded by the GPR155 gene. Mutations in this gene may be associated with autism.

GPR156, is a human gene which encodes a G protein-coupled receptor belonging to metabotropic glutamate receptor subfamily. By sequence homology, this gene was proposed as being a possible GABA_B receptor subunit, however when expressed in cells alone or with other GABA_B subunits, no response to GABA_B ligands could be detected. Therefore, the function of this protein remains to be elucidated. In vitro studies on GPR156 constitutive activity revealed a high level of basal activation and coupling with members of the Gi/Go heterotrimeric G protein family.

Probable G-protein coupled receptor 115 is a protein that in humans is encoded by the GPR115 gene.

Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene. GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.

Probable G-protein coupled receptor 111 is a protein that in humans is encoded by the GPR111 gene.

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. This gene encodes a member of the adhesion-GPCR receptor family. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Probable G-protein coupled receptor 150 is a protein that in humans is encoded by the GPR150 gene.

Probable G-protein coupled receptor 141 is a protein that in humans is encoded by the GPR141 gene.

Probable G-protein coupled receptor 153 is a protein that in humans is encoded by the GPR153 gene.

Probable G-protein coupled receptor 152 is a protein that in humans is encoded by the GPR152 gene.

G-protein coupled receptor 139 (GPC139) is a protein that in humans is encoded by the GPR139 gene. Recent research ('21) has shown that mice with loss of GCP139 experience schizophrenia-like symptomatology that is rescued with the dopamine receptor antagonist haloperidol and the μ-opioid receptor antagonist naltrexone; as well, the recently developed, potent, and GPR139 receptor selective agonist TAK-041 is currently undergoing trials to gauge the efficacy for treating psychiatric conditions such as major depressive disorder and the negative symptoms of schizophrenia.

Probable G-protein coupled receptor 151 is a protein that in humans is encoded by the GPR151 gene.

G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.

Probable G-protein coupled receptor 142 is a protein that in humans is encoded by the GPR142 gene.

G protein-coupled receptor 148, also known as GPR148, is a human orphan receptor from GPCR superfamily. It is expressed primarily in nervous system and testis. Is may be implicated in prostate cancer.

Mas-related G-protein coupled receptor member G (MRGG) also known as G-protein coupled receptor 169 (GPR169) is a protein that in humans is encoded by the MRGPRG gene. MRGG is an orphan G-protein coupled receptor.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174948 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043441 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proc Natl Acad Sci U S A. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi: 10.1073/pnas.0230374100 . PMC 153653 . PMID 12679517.
↑ "Entrez Gene: GPR149 G protein-coupled receptor 149".

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000174948 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043441 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12679517-5] Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proc Natl Acad Sci U S A. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi: 10.1073/pnas.0230374100 . PMC 153653 . PMID 12679517.

[entrez-6] "Entrez Gene: GPR149 G protein-coupled receptor 149".

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