TAS2R5

TAS2R5
Identifiers
Aliases	TAS2R5 , T2R5, taste 2 receptor member 5
External IDs	OMIM: 605062 HomoloGene: 49580 GeneCards: TAS2R5
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q34 Start 141,790,217 bp [1] End 141,791,367 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube canal of the cervix tibial nerve skin of abdomen gastric mucosa stromal cell of endometrium left uterine tube right coronary artery minor salivary gland pituitary gland n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity taste receptor activity bitter taste receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process chemosensory behavior detection of chemical stimulus involved in sensory perception of bitter taste sensory perception of taste signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54429 n/a Ensembl ENSG00000127366 n/a UniProt Q9NYW4 n/a RefSeq (mRNA) NM_018980 n/a RefSeq (protein) NP_061853 n/a Location (UCSC) Chr 7: 141.79 – 141.79 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Taste receptor type 2 member 5 is a protein that in humans is encoded by the TAS2R5 gene. ^[3]

Function

This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. ^[3]

See also

• Taste receptor

References

1. GRCh38: Ensembl release 89: ENSG00000127366 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: TAS2R5 taste receptor, type 2, member 5".

Further reading

• Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10. doi: 10.1016/S0896-6273(00)81054-5 . PMID   10774719.
• Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi: 10.1074/jbc.R100054200 . PMID   11696554.
• Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID   12139982. S2CID   37807140.
• Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2007). "The receptors and cells for mammalian taste". Nature. 444 (7117): 288–94. doi:10.1038/nature05401. PMID   17108952. S2CID   4431221.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi: 10.1016/S0092-8674(00)80705-9 . PMID   10761934. S2CID   14604586.
• Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi: 10.1016/S0092-8674(00)80706-0 . PMID   10761935. S2CID   7293493.
• Firestein S (2000). "The good taste of genomics". Nature. 404 (6778): 552–3. doi: 10.1038/35007167 . PMID   10766221. S2CID   35741332.
• Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. Bibcode:2000Natur.404..601M. doi:10.1038/35007072. PMID   10766242. S2CID   4336913.
• Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi: 10.1016/S0092-8674(03)00071-0 . PMID   12581520. S2CID   718601.
• Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi: 10.1093/molbev/msi027 . PMID   15496549.
• Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC   1449719 . PMID   15744053.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.