P2RY11

P2RY11
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2B6S
Identifiers
Aliases	P2RY11 , P2Y11, purinergic receptor P2Y11
External IDs	OMIM: 602697 HomoloGene: 130446 GeneCards: P2RY11
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.2 Start 10,111,693 bp [1] End 10,115,372 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube skin of abdomen putamen spleen nucleus accumbens caudate nucleus hippocampus proper left lobe of thyroid gland dorsolateral prefrontal cortex Brodmann area 9 n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity G protein-coupled purinergic nucleotide receptor activity signal transducer activity G protein-coupled ATP receptor activity neurotransmitter receptor activity signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure Biological process defense response neuronal signal transduction activation of adenylate cyclase activity G protein-coupled purinergic nucleotide receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway cellular response to ATP calcium-mediated signaling signal transduction G protein-coupled adenosine receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5032 n/a Ensembl ENSG00000244165 n/a UniProt Q96G91 n/a RefSeq (mRNA) NM_002566 n/a RefSeq (protein) NP_002557 n/a Location (UCSC) Chr 19: 10.11 – 10.12 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene. ^{[3] [4]}

The product of this gene, P2Y₁₁, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. ^[4]

See also

• P2Y receptor

References

1. GRCh38: Ensembl release 89: ENSG00000244165 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Communi D, Govaerts C, Parmentier M, Boeynaems JM (Jan 1998). "Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase". J Biol Chem. 272 (51): 31969–73. doi: 10.1074/jbc.272.51.31969 . PMID   9405388.
4. "Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11".

Further reading

• van der Weyden L, Conigrave AD, Morris MB (2000). "Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor". Immunol. Cell Biol. 78 (4): 369–74. doi:10.1046/j.1440-1711.2000.00918.x. PMID   10947861. S2CID   25036526.
• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID   7566098.
• Communi D, Suarez-Huerta N, Dussossoy D, et al. (2001). "Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes". J. Biol. Chem. 276 (19): 16561–6. doi: 10.1074/jbc.M009609200 . PMID   11278528.
• Moore DJ, Chambers JK, Wahlin JP, et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochim. Biophys. Acta. 1521 (1–3): 107–19. doi:10.1016/S0167-4781(01)00291-3. PMID   11690642.
• Duhant X, Schandené L, Bruyns C, et al. (2002). "Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes". J. Immunol. 169 (1): 15–21. doi: 10.4049/jimmunol.169.1.15 . PMID   12077223.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Moreschi I, Bruzzone S, Nicholas RA, et al. (2006). "Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes". J. Biol. Chem. 281 (42): 31419–29. doi: 10.1074/jbc.M606625200 . PMID   16926152.
• Zylberg J, Ecke D, Fischer B, Reiser G (2007). "Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis". Biochem. J. 405 (2): 277–86. doi:10.1042/BJ20061728. PMC   1904521 . PMID   17338680.

External links

• "P2Y Receptors: P2Y₁₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.