GPR114

Last updated

ADGRG5
Identifiers
Aliases ADGRG5 , PGR27, GPR114, adhesion G protein-coupled receptor G5
External IDs OMIM: 616965; MGI: 2685955; HomoloGene: 17828; GeneCards: ADGRG5; OMA:ADGRG5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

221188

382045

Ensembl

ENSG00000159618

ENSMUSG00000061577

UniProt

Q8IZF4

Q3V3Z3

RefSeq (mRNA)

NM_001304376
NM_153837
NM_001318481

NM_001033468
NM_001145972

RefSeq (protein)

NP_001291305
NP_001305410
NP_722579

NP_001028640
NP_001139444

Location (UCSC) Chr 16: 57.54 – 57.59 Mb Chr 8: 95.65 – 95.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene. [5] [6] [7] GPR114 is a member of the adhesion GPCR family. [8] [9] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. [10]

Contents

Tissue distribution

GPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells. [11]

Signaling

The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to Gαs protein. [12]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000159618 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061577 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: GPR114 G protein-coupled receptor 114".
  6. ↑ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. Bibcode:2002FEBSL.531..407F. doi: 10.1016/S0014-5793(02)03574-3 . PMID   12435584. S2CID   7449692.
  7. ↑ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC   4394687 . PMID   25713288.
  8. ↑ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN   978-1-4419-7912-4.
  9. ↑ Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID   23695165. S2CID   6958640.
  10. ↑ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC   3321182 . PMID   22333914.
  11. ↑ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC   4394687 . PMID   25713288.
  12. ↑ Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X (April 2012). "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters. 586 (8): 1214–1219. Bibcode:2012FEBSL.586.1214G. doi: 10.1016/j.febslet.2012.03.014 . PMID   22575658. S2CID   3020230.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.