Neurotensin receptor 2

Last updated
NTSR2
Identifiers
Aliases NTSR2 , NTR2, Neurotensin receptor 2
External IDs OMIM: 605538 MGI: 108018 HomoloGene: 7452 GeneCards: NTSR2
Orthologs
SpeciesHumanMouse
Entrez

23620

18217

Ensembl

ENSG00000169006

ENSMUSG00000020591

UniProt

O95665

P70310

RefSeq (mRNA)

NM_012344

NM_008747
NM_001361702
NM_001361703

RefSeq (protein)

NP_036476

NP_032773
NP_001348631
NP_001348632

Location (UCSC) Chr 2: 11.66 – 11.67 Mb Chr 12: 16.7 – 16.71 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene. [5] [6] [7]

Contents

Function

The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in the brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [7]

See also

Related Research Articles

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<span class="mw-page-title-main">Neurotensin receptor 1</span> Protein-coding gene in the species Homo sapiens

Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene. For a crystal structure of NTS1, see pdb code 4GRV. In addition, high-resolution crystal structures have been determined in complex with the peptide full agonist NTS8-13, the non-peptide full agonist SRI-9829, the partial agonist RTI-3a, and the antagonists / inverse agonists SR48692 and SR142948A, as well as in the ligand-free apo state., see PDB codes 6YVR (NTSR1-H4X:NTS8–13), 6Z4V (NTSR1-H4bmX:NTS8–13), 6Z8N (NTSR1-H4X:SRI-9829), 6ZA8 (NTSR1-H4X:RTI-3a), 6Z4S (NTSR1-H4bmX:SR48692), 6ZIN (NTSR1-H4X:SR48692), 6Z4Q, and 6Z66.

<span class="mw-page-title-main">IL13RA2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">NLN (gene)</span> Protein-coding gene in the species Homo sapiens

Neurolysin, mitochondrial is a protein that in humans is encoded by the NLN gene. It is a 78-kDa enzyme, widely distributed in mammalian tissues and found in various subcellular locations that vary with cell type. Neurolysin exemplifies the ability of neuropeptidases to target various cleavage site sequences by hydrolyzing them in vitro, and metabolism of neurotensin is the most important role of neurolysin in vivo. Neurolysin has also been implicated in pain control, blood pressure regulation, sepsis, reproduction, cancer biology pathogenesis of stroke, and glucose metabolism.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000169006 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020591 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D (May 1996). "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Letters. 386 (2–3): 91–4. doi: 10.1016/0014-5793(96)00397-3 . PMID   8647296. S2CID   5802578.
  6. ↑ Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P (Nov 1998). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". European Journal of Pharmacology. 360 (2–3): 265–72. doi:10.1016/S0014-2999(98)00678-5. PMID   9851594.
  7. 1 2 "Entrez Gene: NTSR2 neurotensin receptor 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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